Development of a MR compatible brain PET II using 4-side tileable GAPD arrays

Jung, Jin Ho; Choi, Yong; Kim, Sangsu; Lim, Hyung Bin; Im, Ki Chun; Choe, Hyeokjun; Huh, Young‐Duk; Kim, Kyu Born; Oh, Chang Hyun; Kim, Kyung Min; Kim, Jong Guk; Park, Hyun-wook

doi:10.1109/nssmic.2012.6551635

Cited by 3 publications

(4 citation statements)

References 9 publications

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“…The preferred coil type for this device is one of the flexible standard coils from the package of P 978-1-4799-0534-8/13/$31.00 ©2013 IEEE coil attachments included with many MRI systems. The third example is the Sogang University PET insert (similar to the WVU Helmet_PET) which has no electronics inside the magnet bore, however the PET ring is large enough to be placed outside the standard birdcage RF head coil at the expense of lower efficiency and/or higher cost, complexity, and weight [5][6][7][8]. Sogang system's electronics readout has no multiplexing as in the operation of Helmet_PET, and overall is larger and more expensive, but also more complex.…”

Section: Introductionmentioning

confidence: 99%

Development of a ring PET insert for MRI

Bauer

Stolin

Proffitt

et al. 2013

2013 IEEE Nuclear Science Symposium and Medical Imaging Conference (2013 NSS/MIC)

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Our research group constructed a 12-module PET detection ring composed of Hamamatsu multi-pixel photon counter (MMPC) silicon photomultiplier (SiPM) detectors placed in a ring that is fully MRI compatible. This brain imager can be placed around the head of a patient (clinical setting) or subject (research setting) and allow for comfortable upright imaging. However, an alternative way to use this device, as enabled by the technology, is to indeed scan individuals in the supine position in conjuncture with current MRI systems. This PET prototype is able to image simultaneously as the MRI scan is occurring, thus maximizing co-registration and the accuracy of the assignment of metabolically active voxels to their anatomically correct counterparts as identified by the MR image. In this study, we first conducted some basic instrumentation tests to ensure the device was functioning properly outside of the MRI, and additionally scan some phantoms (Derenzo; Hoffman Brain) to assess the quality in which our brain imager is able to produce adequate images. After these initial studies, we conducted multiple different experiments inside a 3 Tesla MRI in order to see how the magnetic field would influence the operation of the PET imager and vice versa. Through simultaneous PET/MRI scanning of a Hoffman brain phantom filled with F 18 radioactivity and water, it was shown that the quality of the MR image was largely unaffected by the PET imager. Furthermore, although the quality of PET imaging was affected by the RF pulsing, an acceptable PET image was nevertheless produced. As we discuss following the results, the success of this study shows that our brain imager is indeed MR compatible, and that next generation devices based on its concepts will continue to improve combined PET/MRI functionality.As two of the major advantages of this imager are the potential for low-dose scanning and its adaptability to any MRI scanner, this study suggests that PET/MRI brain imaging with low dose is in principle possible using an insert which could be adapted to any MRI scanner, using standard RF coils for that scanner.

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Section: Introductionmentioning

confidence: 99%

Development of a ring PET insert for MRI

Bauer

Stolin

Proffitt

et al. 2013

2013 IEEE Nuclear Science Symposium and Medical Imaging Conference (2013 NSS/MIC)

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“…The feasibility of the SPM used for the development of high-resolution compact PET and SPECT to integrate with MRI has been studied by many research groups, which is a useful tool for both functional and anatomic imaging [6,7]. However, the design and development of highresolution detector modules based on SPMs into a practical imaging system are still great challenges.…”

Section: Introductionmentioning

confidence: 99%

“…In recent years the silicon photomultiplier (SPM) has aroused considerable attention and interest for applications in nuclear molecular imaging, because of its appealing properties of great compactness with high gain (∼10 6 ), fast response, low current consump-tion and insensitivity to the magnetic field [3][4][5]. The feasibility of the SPM used for the development of high-resolution compact PET and SPECT to integrate with MRI has been studied by many research groups, which is a useful tool for both functional and anatomic imaging [6,7].…”

Section: Introductionmentioning

confidence: 99%

Design and development of compact readout electronics with silicon photomultiplier array for a compact imaging detector

Zhang

Zhao

2012

Chinese Phys. C

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This work aims at developing compact readout electronics for a compact imaging detector module with silicon photomultiplier (SPM) array. The detector module consists of a LYSO crystal array coupling with a SensL's 4×4 SPM array. A compact multiplexed readout based on a discretized positioning circuit (DPC) was developed to reduce the readout channels from 16 to 4 outputs. Different LYSO crystal arrays of 4×4, 8×8 and 12×12 with pixel sizes of 3.2, 1.6 and 1.0 mm respectively, have been tested with the compact readout board using a 137Cs source. The initial results show that the compact imaging detector module with the compact multiplexed readout could clearly resolve 1 mm×1 mm×10 mm LYSO scintillation crystal array except those at the edges. The detector's intrinsic spatial resolution up to 1 mm can be achieved with the 3 mm×3 mm size SPMArray4 through light sharing and compact multiplexed readout. Our results indicate that this detector module is feasible for the development of high-resolution compact PET. Abstract: This work aims at developing compact readout electronics for a compact imaging detector module with silicon photomultiplier (SPM) array. The detector module consists of a LYSO crystal array coupling with a SensL's 4×4 SPM array. A compact multiplexed readout based on a discretized positioning circuit (DPC) was developed to reduce the readout channels from 16 to 4 outputs. Different LYSO crystal arrays of 4×4, 8×8 and 12×12 with pixel sizes of 3.2, 1.6 and 1.0 mm respectively, have been tested with the compact readout board using a 137 Cs source. The initial results show that the compact imaging detector module with the compact multiplexed readout could clearly resolve 1 mm×1 mm×10 mm LYSO scintillation crystal array except those at the edges. The detector's intrinsic spatial resolution up to 1 mm can be achieved with the 3 mm×3 mm size SPMArray4 through light sharing and compact multiplexed readout. Our results indicate that this detector module is feasible for the development of high-resolution compact PET.

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“…F ollowing the recent efforts directed towards the development of dedicated compact PET brain imagers by other groups [1,2,3], and influenced by the concept of the RatCAP, a small animal wearable Positron Emission Tomography (PET) imager [4, S, 6] we embarked on the development of a wearable human PET brain imager, the HelmetPET. The RatCAP was designed to be able to fit on the head of a rat to a surgically implanted attachment point.…”

Section: Introductionmentioning

confidence: 99%

HelmetPET: A silicon photomultiplier based wearable brain imager

Majewski

Proffitt²,

Brefczynski-Lewis

et al. 2011

2011 IEEE Nuclear Science Symposium Conference Record

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We are developing the HelmetPET, a wearable human PET brain imager which has the potential application of evaluating brain function utilizing PET based radiopharmaceuticals in standing, balancing or moving patients. The HeimetPET is composed of two rings of radiation detectors together providing a cylindrical reconstructed volume with an axial length of 5 cm. Each ring is composed of twenty 2.5 cm 2 silicon photomultiplier (SiPM) based detector modules. Each detector module is composed of a 5x5 array of twenty-five Hamamatsu SI0362-33-050P Multi Pixel Photon Counters (MPPCs). The 3 mm 2 MPPCs are arranged on a 5mm step. Coupled to each of the MPPC modules is a L YSO scintillator crystal array coupled to the MPPC array using to two different LYSO pixel arrays: l.Oxl.OxlO mm 3 and 1.5x1.5xlO mm 3 • The current phase of the project is to equip the forty 2.5 cm 2 detector modules with resistive readout and assemble them in a helmet type head support and suspend from a flexible mechanical mount.

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Development of a MR compatible brain PET II using 4-side tileable GAPD arrays

Cited by 3 publications

References 9 publications

Development of a ring PET insert for MRI

Development of a ring PET insert for MRI

Design and development of compact readout electronics with silicon photomultiplier array for a compact imaging detector

HelmetPET: A silicon photomultiplier based wearable brain imager

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