HelmetPET: A silicon photomultiplier based wearable brain imager

Majewski, S.; Proffitt, James; Brefczynski-Lewis, Julie A.; Stolin, Alexander; Weisenberger, A.G.; Xi, Wenze; Wojcik, Randolph

doi:10.1109/nssmic.2011.6153766

Cited by 22 publications

(15 citation statements)

References 9 publications

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“…Although most attempts toward organ-specific imaging were based on stand-alone PET or SPECT systems [100][101][102][103], significant efforts in fully-integrated, organ-specific imaging technologies were made in recent years. For example, Siemens Healthcare did propose a "Brain PET" system that was based on a PET ring insert for a 3 T MR system [104].…”

Section: Organ-specific System Design and Total-body Systemsmentioning

confidence: 99%

Hybrid Imaging: Instrumentation and Data Processing

et al. 2018

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State-of-the-art patient management frequently requires the use of non-invasive imaging methods to assess the anatomy, function or molecular-biological conditions of patients or study subjects. Such imaging methods can be singular, providing either anatomical or molecular information, or they can be combined, thus, providing "anato-metabolic" information. Hybrid imaging denotes image acquisitions on systems that physically combine complementary imaging modalities for an improved diagnostic accuracy and confidence as well as for increased patient comfort. The physical combination of formerly independent imaging modalities was driven by leading innovators in the field of clinical research and benefited from technological advances that permitted the operation of PET and MR in close physical proximity, for example. This review covers milestones of the development of various hybrid imaging systems for use in clinical practice and small-animal research. Special attention is given to technological advances that helped the adoption of hybrid imaging, as well as to introducing methodological concepts that benefit from the availability of complementary anatomical and biological information, such as new types of image reconstruction and data correction schemes. The ultimate goal of hybrid imaging is to provide useful, complementary and quantitative information during patient work-up. Hybrid imaging also opens the door to multi-parametric assessment of diseases, which will help us better understand the causes of various diseases that currently contribute to a large fraction of healthcare costs.

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Section: Organ-specific System Design and Total-body Systemsmentioning

confidence: 99%

Hybrid Imaging: Instrumentation and Data Processing

et al. 2018

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“…Additionally, reconstruction artifacts due to missing sectors in the angular coverage are substantially reduced (Surti and Karp 2007, Gong et al 2015a). Both approaches are being investigated for the development of an ambulatory micro-dose brain PET imager (AMPET) (Majewski et al 2011, Bauer et al 2014, Kinahan et al 2015, Gong et al 2015b). The objective of the AMPET is to understand normal and disordered human brain of upright, moving persons in natural environments.…”

Section: Introductionmentioning

confidence: 99%

Designing a compact high performance brain PET scanner—simulation study

et al. 2016

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The desire to understand normal and disordered human brain function of upright, moving persons in natural environments motivates the development of the ambulatory micro-dose brain PET imager (AMPET). An ideal system would be light weight but with high sensitivity and spatial resolution, although these requirements are often in conflict with each other. One potential approach to meet the design goals is a compact brain-only imaging device with a head-sized aperture. However, a compact geometry increases parallax error in peripheral lines of response, which increases bias and variance in region of interest (ROI) quantification. Therefore, we performed simulation studies to search for the optimal system configuration and to evaluate the potential improvement in quantification performance over existing scanners. We used the Cramér–Rao variance bound to compare the performance for ROI quantification using different scanner geometries. The results show that while a smaller ring diameter can increase photon detection sensitivity and hence reduce the variance at the center of the field of view, it can also result in higher variance in peripheral regions when the length of detector crystal is 15 mm or more. This variance can be substantially reduced by adding depth-of- interaction (DOI) measurement capability to the detector modules. Our simulation study also shows that the relative performance depends on the size of the ROI, and a large ROI favors a compact geometry even without DOI information. Based on these results, we propose a compact ‘helmet’ design using detectors with DOI capability. Monte Carlo simulations show the helmet design can achieve four-fold higher sensitivity and resolve smaller features than existing cylindrical brain PET scanners. The simulations also suggest that improving TOF timing resolution from 400 ps to 200 ps also results in noticeable improvement in image quality, indicating better timing resolution is desirable for brain imaging.

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“…The AM-PET Helmet_PET was developed to create a portable PET brain scanner for more individualized brain imaging as compared to the commonly known PET/CT scanner where the patient is required to remain still in an isolated environment [ 12 , 16 ]. The original AM-PET Helmet_PET is composed of twelve photo-detector modules evenly spaced around a patient’s head.…”

Section: Methodsmentioning

confidence: 99%

Development and Design of Next-Generation Head-Mounted Ambulatory Microdose Positron-Emission Tomography (AM-PET) System

Melroy

Bauer

McHugh

et al. 2017

Sensors

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Several applications exist for a whole brain positron-emission tomography (PET) brain imager designed as a portable unit that can be worn on a patient’s head. Enabled by improvements in detector technology, a lightweight, high performance device would allow PET brain imaging in different environments and during behavioral tasks. Such a wearable system that allows the subjects to move their heads and walk—the Ambulatory Microdose PET (AM-PET)—is currently under development. This imager will be helpful for testing subjects performing selected activities such as gestures, virtual reality activities and walking. The need for this type of lightweight mobile device has led to the construction of a proof of concept portable head-worn unit that uses twelve silicon photomultiplier (SiPM) PET module sensors built into a small ring which fits around the head. This paper is focused on the engineering design of mechanical support aspects of the AM-PET project, both of the current device as well as of the coming next-generation devices. The goal of this work is to optimize design of the scanner and its mechanics to improve comfort for the subject by reducing the effect of weight, and to enable diversification of its applications amongst different research activities.

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HelmetPET: A silicon photomultiplier based wearable brain imager

Cited by 22 publications

References 9 publications

Hybrid Imaging: Instrumentation and Data Processing

Hybrid Imaging: Instrumentation and Data Processing

Designing a compact high performance brain PET scanner—simulation study

Development and Design of Next-Generation Head-Mounted Ambulatory Microdose Positron-Emission Tomography (AM-PET) System

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