Development of a modified QuEChERS method for the determination of veterinary antibiotics in swine manure by liquid chromatography tandem mass spectrometry

Guo, Chunna; Wang, Mingru; Xi, Hui; Huai, Binbin; Wang, Feng; Pan, Guangfang; Liao, Xiao‐Ping; Liu, Yahong

doi:10.1016/j.jchromb.2016.05.034

Cited by 80 publications

(33 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It was reported that the ultrasonic bath makes a difference on the extraction procedure [3]. The comparison with and without ultrasonic bath were studied.…”

Section: Optimization Of Extractionmentioning

confidence: 99%

“…Antibiotics are widely used in large quantities in breeding industry and can protect animals from diseases [1,2], but they can also be excreted by animals as parent compounds and may thus enter the soil and surrounding streams by the application of organic fertilizer [3]. During the last four or five decades, the increasing use of these drugs has caused substantial environmental problems, which proved to be a matter of great concern.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Simultaneous extraction and determination of antibiotics in soils using a method based on quick, easy, cheap, effective, rugged, and safe extraction and liquid chromatography with tandem mass spectrometry

Meng

et al. 2017

J of Separation Science

View full text Add to dashboard Cite

The increasing use of antibiotics has caused substantial environmental problems, which are a matter of great concern. The aim of this work was to develop a quick, easy, cheap, effective, rugged, and safe method for 20 antibiotic residues in soil. The developed method is based on extraction with acetonitrile and phosphate buffer, clean up with dispersive solid-phase extraction adsorbent using primary secondary amine, octadecylsilane, followed by liquid chromatography with tandem mass spectrometry determination. We optimized different extraction methods and the ratio of cleanup adsorbents to achieve good recoveries at seven spiking levels that ranged from 61.4 to 118.9% with a relative standard deviation below 20% (n = 5). The method quantification limit was in the range of 2-5 μg/kg for most analytes. Good linear regression coefficients greater than 0.990 were obtained. This method was applied for the analysis of real agricultural soil samples, confirming the feasibility of the method.

show abstract

“…It was reported that the ultrasonic bath makes a difference on the extraction procedure [3]. The comparison with and without ultrasonic bath were studied.…”

Section: Optimization Of Extractionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Simultaneous extraction and determination of antibiotics in soils using a method based on quick, easy, cheap, effective, rugged, and safe extraction and liquid chromatography with tandem mass spectrometry

Meng

et al. 2017

J of Separation Science

View full text Add to dashboard Cite

show abstract

“…This approach was originally developed for low-fat fruit and vegetable matrices (Anastassiades et al 2003); subsequently, it was successfully applied for a variety of matrices and analytes by both gas and liquid chromatography techniques (Vera et al 2013;González-Curbelo et al 2015;Rejczak and Tuzimski 2015). Lately, this method, with some modifications, has been used to identify CECs in solid matrices such as animal feed (Lopes et al 2012), seafood (Cunha et al 2012), animal tissues (Pouech et al 2012;Berge and Vulliet 2015;Yao et al 2016), sewage sludge (Peysson and Vulliet 2013;Cerqueira et al 2014), sediments (Berlioz-Barbier et al 2014;Carmona et al 2014;Czech et al 2016;Santos et al 2016;Dos Santos et al 2018), and manure (Guo et al 2016). Berlioz-Barbier et al utilized QuEChRS for the first time to document 15 CECs (PPCPs, pesticides, and hormones) in sediment samples.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Analysis of Multiclass Contaminants of Emerging Concern in Sediments by Liquid Chromatography with Tandem Quadrupole Mass Spectrometry

Rashid

Wang

et al. 2019

Enviro Toxic and Chemistry

View full text Add to dashboard Cite

A quick, easy, cheap, effective, rugged, and safe (QuEChERS)‐based extraction and simultaneous dispersive solid‐phase extraction (dSPE) clean‐up method was developed for contaminants of emerging concern (CECs) in sediment samples. Hydration with a phosphate buffer (pH 2.0) and salting out with NaCl and MgSO4 facilitated the extraction and liquid–liquid portioning of the aqueous and organic phases. Cleanup of the extracts was achieved by florisil and C18 (1:1) sorbents in dSPE with minimal compromise of the analytes. The extracts were clean enough for determination by liquid chromatography–tandem mass spectrometry (LC‐MS/MS). The procedure was validated for preservatives, blood lipid regulators, analgesics and anti‐inflammatory drugs, plasticizers, and other classes of CECs in sediment matrix spiked at 6 levels between 1‐ and 40‐fold concentrations for CECs of varying analytical sensitivities. The recovery values were generally between approximately 27 and 120% and the relative standard deviation (%RSD) values were below 20% at 10‐ , 20‐ , and 40‐fold spiking levels, albeit the recoveries for some analytes dropped at low spike concentrations. The method showed high sensitivity where the method detection limits (MDLs) were at low ppb levels for the majority of the analytes that ranged between 0.002 and 1.93 µg/kg. The method performance was also compared with well‐established US Environmental Protection Agency (USEPA) Method 1694 by analyzing sediment samples collected from Yundang Lagoon (Xiamen, China) with field‐incurred CEC residues. The sediment samples were detected with residues of parabens, gemfibrozil, ketoprofen, naproxen, fenoprofen, diclofenac, miconazole, carbamazepine, benzophenon‐3, glibenclamide, sildinafil citrate, and some bisphenol analogues. Environ Toxicol Chem 2019;38:1409–1422. © 2019 SETAC

show abstract

“…Antibiotics may be used for different purposes, from the therapeutic and/or preventive use in the treatment of diseases, such as infections, diarrhea, or even as growth promoters (CHENG et al, 2019;BEN et al, 2017;TASHO;CHO, 2016;GUO et al, 2016;QIAN et al, 2016a). Several authors (CHENG et al, 2019;TASHO;CHO, 2016;GUO et al, 2016;GELBAND et al, 2015;DAGHRIR;DROGUI, 2013;DU;LIU, 2012), indicate that, on average, 60% of the veterinary drug administered to the animals is excreted through urine and feces (PULICHARLA et al, 2017), and the most commonly used group of drugs is antibiotics (TASHO; CHO, 2016. Among them, tetracycline, sulfonamides, macrolides, and fluoroquinolones stand out (CHENG et al, 2019;SOLLIEC et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

“…Veterinary drug residues can reach the soil and the water resources (QIAN et al, 2016b;GUO et al, 2016;SOLLIEC et al, 2016) as unchanged substances or metabolites (SOLLIEC et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Compostagem de efluente suíno no tratamento de resíduos de fármacos veterinários

Bohrer

Carissimi

López

et al. 2019

SCA

View full text Add to dashboard Cite

The increasing need for animal protein has exerted pressures on the current animal production system. One of the alternatives found by producers to improve animal performance has been the use of veterinary drugs, especially antibiotics. However, its indiscriminate use can be a risk to the environmental balance of the producing locations since Brazil has approximately 42 million pigs. With this herd, pig farming represents a great potential for generating environmental impacts. As an alternative use of the large volume of liquid pig manure generated, many producers have been using this slurry in the soil as a bio fertilizer. Residues of veterinary drugs are capable of accumulation with environmental matrices and leach into water resources. In this sense, it is mandatory to dedicate more efforts on the study of techniques and processes for the treatment of organic effluents contaminated by veterinary drugs. Low-cost and environmentally friendly alternative treatment systems are necessary, in order to minimize the entry of these contaminants into the environment. Therefore, the composting process, defined as aerobic microbial decomposition process of organic matter, can be an alternative for treating the effluents contaminated by veterinary drugs. This review to aims to create awareness in the academic community regarding the veterinary drug residues and their contamination potential in different environmental matrices, as well as evaluating the composting process as a technique to minimize the impacts of the swine activity waste on the environment.

show abstract

Development of a modified QuEChERS method for the determination of veterinary antibiotics in swine manure by liquid chromatography tandem mass spectrometry

Cited by 80 publications

References 30 publications

Simultaneous extraction and determination of antibiotics in soils using a method based on quick, easy, cheap, effective, rugged, and safe extraction and liquid chromatography with tandem mass spectrometry

Simultaneous extraction and determination of antibiotics in soils using a method based on quick, easy, cheap, effective, rugged, and safe extraction and liquid chromatography with tandem mass spectrometry

Simultaneous Analysis of Multiclass Contaminants of Emerging Concern in Sediments by Liquid Chromatography with Tandem Quadrupole Mass Spectrometry

Compostagem de efluente suíno no tratamento de resíduos de fármacos veterinários

Contact Info

Product

Resources

About