Abstract:In the recent years the methods of synthesis and biological activity of phosphorus-containing analogues of biogenic carboxylic acids that are potential anti-metabolites of corresponding endogenous ligands in metabolic processes have been intensively studied. Phosphonacetic (PAA) and phosphonformic acids are the most important biological active phosphorus-containing carboxylic acids. Antiviral activity of phosphonacetic acid and some it’s derivates via inhibition of replication of viral DNA is proven by a numb… Show more
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