Development of a long-life capillary enzyme bioreactor for the determination of blood glucose

Ho, Ja‐an Annie; Wu, Li-Chen; Fan, Nien-Chu; Lee, Ming-Shih; Kuo, Hung-Yi; Yang, Chung‐Shi

doi:10.1016/j.talanta.2006.04.023

Cited by 23 publications

(6 citation statements)

References 30 publications

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“…For example, an ionic silver‐zeolite was used in the electrochemical sensor of DNA hybridization , an amperometric biosensor with glucose oxidase (GOx) immobilized on zeolites as bioselective elements, and platinum disk electrode as transducer was used . A long‐life capillary enzyme bioreactor was developed and constructed by immobilizing glucose oxidase onto the inner surface of a fused‐silica capillary that was part of a flow system , enzyme laccase was immobilized on mesoporous silica powder coated onto a glassy carbon electrode using an electrophoretic deposition technique, and the electrode was then used for amperometric detection of catechol . Mesoporous silica particles SBA‐15 with fiber, rod and cuboid morphologies of increasing mesoporous diameter were synthesized and used to understand the role of the structural parameters on enzyme activity in the glucose oxidase biosensor .…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Biosensors Based on Enzymatic Reactors Filled by Various Types of Silica and Amalgam Powders for Measurements in Flow Systems

2016

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Two enzymatic biosensors with amalgam powder reactors and twelve enzymatic biosensors with various silica powder reactors were fabricated and tested in this work. The enzymatic reactors based on silver amalgam powder provide high sensitivity and they are convenient for faster flow rates. Experiments with six silica materials showed that mesoporous silica SBA‐15 was the best one in terms of covering by enzymes, sensitivity and lifetime of biosensors. The current response of the SBA15‐glucose oxidase (GOx) sensor started to decrease only after 200 day testing and after 406 days the peak current was still 35.9 % of the initial value. The used amalgam tubular detector in a flow system allowed working at highly negative potentials, which significantly increased the sensitivity of determinations. Statistical results of parallel measurement of model solutions with the fabricated biosensors show their high accuracy (RSD=0.28–1.81 %) and sensitivity (6.2–14.3 µmol L−1). The proposed SBA15‐GOx biosensor was successfully used for determination of glucose in commercial honey.

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Section: Introductionmentioning

confidence: 99%

Electrochemical Biosensors Based on Enzymatic Reactors Filled by Various Types of Silica and Amalgam Powders for Measurements in Flow Systems

2016

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“…Ho and co-workers developed a long-life capillary enzyme bioreactor for the determination of blood glucose concentration with high sensitivity and satisfactory stability. 305 The bioreactor was constructed by immobilizing GOx onto the inner surface of a fused-silica capillary (ID = 0.53 mm). Operational and storage stability of this enzyme bioreactor was maintain for at least 120 days.…”

Section: Biocatalytic Oxidation Reactions In Flowmentioning

confidence: 99%

Continuous flow technology-a tool for safer oxidation chemistry

et al. 2022

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“…48 Other additional work has been conducted on lifestyle management factors for patients with diabetes. 49,50 Jung et al optimized a stable cell culture condition within a packed-bed bioreactor for production of tagatose, a novel bulk sweetener that tastes similar to sucrose with potential to be used as a low-calorie sweetener in foods, beverages, health foods, and dietary supplements. 49 Ho et al developed a long-life capillary enzyme bioreactor for highly sensitive determination of blood glucose concentration.…”

Section: Diabetes Mellitusmentioning

confidence: 99%

“…49 Ho et al developed a long-life capillary enzyme bioreactor for highly sensitive determination of blood glucose concentration. 50…”

Section: Diabetes Mellitusmentioning

confidence: 99%

Bioreactors Addressing Diabetes Mellitus

Minteer

Gerlach

Marra

2014

J Diabetes Sci Technol

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The concept of bioreactors in biochemical engineering is a well-established process; however, the idea of applying bioreactor technology to biomedical and tissue engineering issues is relatively novel and has been rapidly accepted as a culture model. Tissue engineers have developed and adapted various types of bioreactors in which to culture many different cell types and therapies addressing several diseases, including diabetes mellitus types 1 and 2. With a rising world of bioreactor development and an ever increasing diagnosis rate of diabetes, this review aims to highlight bioreactor history and emerging bioreactor technologies used for diabetes-related cell culture and therapies.

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Development of a long-life capillary enzyme bioreactor for the determination of blood glucose

Cited by 23 publications

References 30 publications

Electrochemical Biosensors Based on Enzymatic Reactors Filled by Various Types of Silica and Amalgam Powders for Measurements in Flow Systems

Electrochemical Biosensors Based on Enzymatic Reactors Filled by Various Types of Silica and Amalgam Powders for Measurements in Flow Systems

Continuous flow technology-a tool for safer oxidation chemistry

Bioreactors Addressing Diabetes Mellitus

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