Development of a list of potentially inappropriate medications for patients with heart failure (PIMHF)

Jenghua, Kittipak; Chinwong, Surarong; Chinwong, Dujrudee; Kanjanarat, Penkarn

doi:10.1016/j.sapharm.2020.07.021

Cited by 6 publications

(26 citation statements)

References 42 publications

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“…St Vincent's list of 11 PIMHF was used in Bermingham's study, 25 whereas the Thailand list of PIMHF containing 47 PIMHF items was used in our study. 26 Thus, the chance of finding HF patients receiving PIMHF was greater in our study. A comparison between the two study hospitals found that the prevalence of overall PIMHF use was higher in the secondary-care hospital compared with that in the tertiary-care hospital.…”

Section: Discussionmentioning

confidence: 59%

“…Such a difference in prevalence resulted primarily from the different list of PIMHF used in detecting PIMHF. St Vincent's list of 11 PIMHF was used in Bermingham's study, 25 whereas the Thailand list of PIMHF containing 47 PIMHF items was used in our study 26 . Thus, the chance of finding HF patients receiving PIMHF was greater in our study.…”

Section: Discussionmentioning

confidence: 81%

“…According to the Thailand list of PIMHF, all listed medications are considered as PIMHF for any type of HF, except for diltiazem and verapamil (which are considered PIMHF only when used in HFrEF). Sildenafil is considered as PIMHF only when used with nitrates 26 . At the time of this study, 21 and 36 PIMHF items were found to be available at secondary‐ and tertiary‐care hospitals, respectively.…”

Section: Methodsmentioning

confidence: 96%

“…Sildenafil is considered as PIMHF only when used with nitrates. 26 At the time of this study, 21 and 36 PIMHF items were found to be available at secondary-and tertiary-care hospitals, respectively. A period of 4 years (2016-2019) was chosen to study the prevalence because PIMHF use was more likely to be detected in this period than at one time point.…”

Section: What's Newmentioning

confidence: 95%

“…25 Recently, a list of PIMHF has been developed in Thailand. 26 This explicit set of criteria contains 47 consensual PIMHF items considered relevant to Thai HF patients. PIMHF use in Thai HF patients in real clinical practice is unknown.…”

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confidence: 99%

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Prevalence and associated factors of potentially inappropriate medications among Thai patients with heart failure

Jenghua

2020

Int J Clin Pract

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Background Several medications may worsen heart failure (HF), and they are considered as potentially inappropriate medications for patients with heart failure (PIMHF). No studies reported the prevalence of PIMHF use and its associated factors in Thai HF patients. Objective To determine the prevalence of PIMHF use and identify factors associated with PIMHF use. Material and Method A cross‐sectional study was conducted using data on HF patients obtained from the electronic medical databases (EMDs) of two hospitals, including a secondary and a tertiary care hospital. Data collected included demographics, diagnoses and medications prescribed during 2016‐2019. The prevalence of PIMHF use identified by the Thailand list of PIMHF was determined. Patient and clinical factors were examined whether they were associated with PIMHF use by calculating the adjusted odds ratio (aOR) and 95% confidence interval (95% CI) using a binary logistic regression analysis. Results From the EMD, 972 and 2888 eligible HF patients from a secondary and a tertiary care hospital, respectively, were included in this study. The prevalence of PIMHF use was 45.16% and 33.07% at a secondary and a tertiary care hospital, respectively. Factors associated with PIMHF use were HFpEF (aOR = 1.68, 95% CI = 1.39‐2.03), diabetes mellitus (DM) (aOR = 1.66, 95% CI = 1.35‐2.05), renal failure (RF) (aOR = 1.49, 95% CI = 1.21‐1.84), chronic pulmonary diseases (CPD) (aOR = 2.41, 95% CI = 1.74‐3.34), connective tissue diseases (CTD) (aOR = 5.21, 95% CI = 2.17‐12.49), and cancer (aOR = 2.57, 95% CI = 1.36‐4.86). Conclusion PIMHF use according to the Thailand list of PIMHF was prevalent in Thai HF patients and associated with HFpEF, DM, RF, CPD, CTD and cancer.

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Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 81%

Section: Methodsmentioning

confidence: 96%

Section: What's Newmentioning

confidence: 95%

mentioning

confidence: 99%

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