Prevalence and associated factors of potentially inappropriate medications among Thai patients with heart failure

Abstract

Background Several medications may worsen heart failure (HF), and they are considered as potentially inappropriate medications for patients with heart failure (PIMHF). No studies reported the prevalence of PIMHF use and its associated factors in Thai HF patients. Objective To determine the prevalence of PIMHF use and identify factors associated with PIMHF use. Material and Method A cross‐sectional study was conducted using data on HF patients obtained from the electronic medical databases (EMDs) of two hospitals, including a secondary and a tertiary care hospital. Data collected included demographics, diagnoses and medications prescribed during 2016‐2019. The prevalence of PIMHF use identified by the Thailand list of PIMHF was determined. Patient and clinical factors were examined whether they were associated with PIMHF use by calculating the adjusted odds ratio (aOR) and 95% confidence interval (95% CI) using a binary logistic regression analysis. Results From the EMD, 972 and 2888 eligible HF patients from a secondary and a tertiary care hospital, respectively, were included in this study. The prevalence of PIMHF use was 45.16% and 33.07% at a secondary and a tertiary care hospital, respectively. Factors associated with PIMHF use were HFpEF (aOR = 1.68, 95% CI = 1.39‐2.03), diabetes mellitus (DM) (aOR = 1.66, 95% CI = 1.35‐2.05), renal failure (RF) (aOR = 1.49, 95% CI = 1.21‐1.84), chronic pulmonary diseases (CPD) (aOR = 2.41, 95% CI = 1.74‐3.34), connective tissue diseases (CTD) (aOR = 5.21, 95% CI = 2.17‐12.49), and cancer (aOR = 2.57, 95% CI = 1.36‐4.86). Conclusion PIMHF use according to the Thailand list of PIMHF was prevalent in Thai HF patients and associated with HFpEF, DM, RF, CPD, CTD and cancer.

Study of medication use and effects of medication among hospitalized older Buddhist monks: An embedded mixed‐method study

“…Most hospitalized older Buddhist monks had chronic diseases, and more than 50% had one or more chronic diseases. To a previous study, up to 90% of older people and 20% of Buddhist monks had various chronic diseases (Jenghua et al, 2019;National Office of Buddhism, 2017). This study found that hypertension was the most common chronic disease, consistent to a survey; up to 70% of the population had hypertension, which had a positive relationship with age (Yotsombut, 2010).…”

“…Based on the literature review, we found various studies on medication use behaviours and problems with medication used in adults, older adults and Buddhist monks. The problems could be summarized as multiple drug use, none adherence, the adjusted dose of medicine and side effects of medication use (Artsanthia & Techakuljareon, 2019; Champunot, 2011; Chotvirut & Tanchaloemchai, 2010; Darunthanom et al, 2019; Jenghua et al, 2019; Suvithanpatthanabandit et al, 2015; Suwannapong & Klungrit, 2019; Yotsombut, 2010). However, those studies were separately conducted and explored the problem of self‐medication in the community.…”

“…Medication use is defined as the processes and ways/methods of using medication to release unpleasant symptoms, promote organ function and disease treatment (Suwannapong & Klungrit, 2019;Vogenberg & Benjamin, 2011). Meanwhile, the effects of the medication were the results of medication use, and it can be both treatment effects and side effects/adverse events (Artsanthia & Techakuljareon, 2019;Jenghua et al, 2019). Based on the literature review, we found various studies on medication use behaviours and problems with medication used in adults, older adults and Buddhist monks.…”

“…Aekplakorn (2016) found that older adults used medicines more than other age groups. Jenghua et al (2019) also reported that 90% of Thai community‐dwelling older adults had one or more chronic diseases, and the medical prescription was 4–5 medicines. Multiple drug use causes older adults to be more likely to have problems from medication use (Aekplakorn, 2016; Assantachai, 2021).…”

Evaluation of the integrated model of the rational drug use into the Bachelor of Nursing Science program in Thailand: A mixed-methods study

“…Importantly, irrational drug use is common in persons with chronic illnesses such as cancer (Seangrung et al, 2020 ) and diabetes mellitus (Yensabai et al, 2016 ). In addition, a high prevalence of potentially inappropriate medication use was found among older Thai persons (Jenghua et al, 2019 ; Vatcharavongvan & Puttawanchai, 2019 ).…”