Development of a laser-driven proton accelerator for cancer therapy

M., C.; Veltchev, I; Fourkal, E; Li, J. S.; Luo, Wei; Fan, Jiaqi; Lin, Tao; Pollack, Alan

doi:10.1134/s1054660x06040165

Cited by 63 publications

(35 citation statements)

References 13 publications

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“…As a promising alternative to conventional proton sources, compact laser plasma based accelerators have been suggested [5][6][7][8][9][10][11]. Practically, LDPR originates from hydrogenated contaminants on almost any solid target surface when irradiated with sufficiently intense ultrashort-pulse laser light [12].…”

Section: Introductionmentioning

confidence: 99%

Dose-controlled irradiation of cancer cells with laser-accelerated proton pulses

et al. 2012

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Proton beams are a promising tool for the improvement of radiotherapy of cancer, and compact laserdriven proton radiation (LDPR) is discussed as an alternative to established large-scale technology facilitating wider clinical use. Yet, clinical use of LDPR requires substantial development in reliable beam generation and transport, but also in dosimetric protocols as well as validation in radiobiological studies. Here, we present the first dose-controlled direct comparison of the radiobiological effectiveness of intense proton pulses from a laser-driven accelerator with conventionally generated continuous proton beams, demonstrating a first milestone in translational research. Controlled dose delivery, precisely online and offline monitored for each out of *4,000 pulses, resulted in an unprecedented relative dose uncertainty of below 10 %, using approaches scalable to the next translational step toward radiotherapy application.

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Section: Introductionmentioning

confidence: 99%

Dose-controlled irradiation of cancer cells with laser-accelerated proton pulses

et al. 2012

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“…Such proposed schemes were based on a compact beamline with a primary collimator in front of a magnetic chicane filter [19,48]. Due to the very small opening angle (0.6°) of the primary collimator, used to limit diverging LAP bunches, such beamline uses a mere of *0.02 % of all protons in a bunch for dose delivery [50], while depositing huge numbers of protons in beam dumps and producing a high level of secondary (background) radiations.…”

Section: Laser-driven Versus Conventional Ibt Dose Deliverymentioning

confidence: 99%

“…Uniform doses in clinical settings with LAP bunches can be delivered either by filtering out quasi-monoenergetic (DE=E *5-10 %) protons from a predicted therapeutic broad LAP spectrum and superimpose multiple filtered bunches akin to con-IBT [19,48] or to achieve a SOBP by a single filtered broad energy bunch in combination with shaping the energy spectrum by physical wedges [49]. Such proposed schemes were based on a compact beamline with a primary collimator in front of a magnetic chicane filter [19,48].…”

Section: Laser-driven Versus Conventional Ibt Dose Deliverymentioning

confidence: 99%

“…Therefore, new methods and techniques for beam transport, irradiation field formation and treatment planning [19][20][21], along with beam-monitoring, dosimetry and dose-controlled irradiation [22][23][24][25][26] are required. Moreover, determination of radio-biological effects induced by ultrashort intense particle bunches [26][27][28][29][30][31][32] is necessary.…”

Section: Introductionmentioning

confidence: 99%

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A compact solution for ion beam therapy with laser accelerated protons

et al. 2014

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The recent advancements in the field of laserdriven particle acceleration have made Laser-driven Ion Beam Therapy (L-IBT) an attractive alternative to the conventional particle therapy facilities. To bring this emerging technology to clinical application, we introduce the broad energy assorted depth dose deposition model which makes efficient use of the large energy spread and high dose-per-pulse of Laser Accelerated Protons (LAP) and is capable of delivering homogeneous doses to tumors. Furthermore, as a key component of L-IBT solution, we present a compact iso-centric gantry design with 360°r otation capability and an integrated shot-to-shot energy selection system for efficient transport of LAP with large energy spread to the patient. We show that gantry size could be reduced by a factor of 2-3 compared to conventional gantry systems by utilizing pulsed air-core magnets.

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“…for ion acceleration [6][7][8][9], laser-assisted fast ignition scenaria for fusion [10][11][12]. Experimental low-temperature plasmas [13] and plasmas for medical applications [14][15][16][17][18] (e.g. cancer therapy) involving plasma expansion mechanisms have received increasing attention in the last few years.…”

Section: Introductionmentioning

confidence: 99%