Development of a Controlled Release System for Risperidone Using Polypyrrole: Mechanistic Studies

Svirskis, Darren; Wright, Bryon E.; Travaš-Sejdić, Jadranka; Rodgers, Anthony; Garg, Sanjay

doi:10.1002/elan.200900401

Cited by 48 publications

(26 citation statements)

References 25 publications

(29 reference statements)

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“…A parametric study, implementing different CV‐ranges, unraveled that release triggering is not solely based on the elimination of the electrostatical binding of the dopant to the polymer. Moreover, the mechanical actuation of the polymer contributes significantly to the release of the drug and the monomer as has been described by others for different drugs . The EDOT could be shown to originate from the polymer bulk.…”

Section: Resultsmentioning

confidence: 63%

“…However, there is also a considerable release of both Dex and EDOT in the anodic sweep, which indicates that not only the electrostatical mechanism but also the swelling and deswelling of the film during actuation contribute significantly to the drug release. Studies by Svirskis et al showed the successful release of cationic (risperidone) as well as neutral (progesterone) substances during electrical activation of a PPy film, which demonstrates the substantial effect of mechanical film actuation on the expulsion of charged and uncharged molecules. This mechanical release mechanism is further believed to dominate the active EDOT release from our samples as no clear suppression can be seen in any of the sweep ranges, which would be expected for a direct correlation to the sweeping potential.…”

Section: Discussionmentioning

confidence: 99%

“…1 The proposed mechanism thereby is that drugs, incorporated in the polymer during synthesis, are released by electrostatical forces, supported by a mechanical actuation due to interaction of the polymer with the surrounding electrolyte during redox cycling. [2][3][4][5] Such redox triggered release has been shown for a variety of biologically relevant molecules, for example Dex, nerve growth factor, brain-derived neurotrophic factor, adenosine 5 0 -triphosphate, risperidone and progesterone 2,[4][5][6][7][8][9][10][11][12][13] and results show that release is influenced by the current passed over the interface upon redox cycling as well as conformational changes in the film associated with the electrochemical processes. A detailed description of multiple polymer based release systems can be found in the excellent reviews of Svirskis et al 14 and Pillay et al 15 What is however not accounted for in most of the previous studies is the possibility of other substances leaving the polymer film as a result of the extensive voltage excursion.…”

Section: Introductionmentioning

confidence: 99%

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A detailed insight into drug delivery from PEDOT based on analytical methods: Effects and side effects

Boehler

Asplund

2014

J Biomedical Materials Res

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The possibility to release drugs from conducting polymers, like polypyrrole or poly(3,4-ethylenedioxythiophene) (PEDOT), has been described and investigated for a variety of different substances during the last years, showing a wide interest in these release systems. A point that has not been looked at so far however is the possibility of other substances, next to the intended ones, leaving the polymer film under the high voltage excursions during redox sweeping. In this study we target this weakness of commonly used detection methods by implementing a high precision analytical method (high-performance liquid chromatography) that allows a separation and subsequently a detailed quantification of all possible release products. We could identify a significantly more complex release behavior for a PEDOT:Dex system than has been assumed so far, revealing the active release of the monomer upon redox activation. The released EDOT could thereby be shown to result from the bulk material, causing a considerable loss of polymer (>10% during six release events) that could partly account for the observed degradation or delamination effects of drug-eluting coatings. The monomer leakage was found to be substantially higher for a PEDOT:Dex film compared to a PEDOT:PSS sample. This finding indicates an overestimation of drug release if side products are mistaken for the actual drug mass. Moreover the full picture of released substances implements the need for further studies to reduce the monomer leakage and identify possible adverse effects, especially in the perspective of releasing an anti-inflammatory substance for attenuation of the foreign body reaction toward implanted electrodes. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 1200–1207, 2015.

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Section: Resultsmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A detailed insight into drug delivery from PEDOT based on analytical methods: Effects and side effects

Boehler

Asplund

2014

J Biomedical Materials Res

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“…For example, small molecule drugs such as, glutamate, 13 dexamethasone, 14 risperdone, 15 etc. can be released from conducting polymer thin films.…”

Section: Introductionmentioning

confidence: 99%

Electrically controlled release of insulin using polypyrrole nanoparticles

et al. 2017

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Conducting polymers present an opportunity for developing programmable, adjustable, spatially, and temporally controllable drug delivery systems. While several small molecule drugs have been released from thin conductive polymeric films successfully, delivering large molecule therapeutics, such as polypeptides and nucleic acids, has remained a significant challenge. Poor drug loading (~ng/cm2) of thin films coupled with film instability has, in many cases, made conducting polymer films refractory to clinical development. To address these limitations, we have utilized conductive polymer nanoparticulate backbones to controllably release insulin, a high molecular weight, clinically relevant polypeptide. We find that the interaction between insulin and the polymer scaffold can be described by a simple Langmuir-type adsorption model. By modifying the ratio of the amount of nanoparticles to the amount of insulin, we have obtained drug loading percentages estimated to be as high as 51 wt% percent. In vivo experiments in mice confirmed retained bioactivity of the released insulin after electrical stimulation.

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“…Os PCs têm sido estudados em diversas aplicações tecnológicas: músculos artificiais [51][52][53][54], sistemas inteligentes de liberação controlada [7,[55][56][57][58][59], engenharia de tecido [60][61][62][63][64], biosensores [65][66][67], neurônios artificiais [68][69][70][71][72], supercapacitores [73][74][75][76][77][78] …”

Section: Aplicações Dos Pcsunclassified

Síntese e caracterização de hidro-esponjas de polímeros condutores

Antonio¹

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Síntese e caracterização de hidro-esponjas de polímeros condutores Orientador (a): Prof (a). Dr (a). Susana Ines Cordoba de TorresiSão Paulo 2016Dedicatória À Kellyda Cinnara por toda paciência, dedicação, amor e apoio incondicional à minha luta.À minha família, Maria Dalva, Maria de Lourdes, Joaquim, Quinca e Alexandra, por terem me ensinado a lutar, ser honesto e ajudado a fazer deste sonho, realidade. AGRADECIMENTOA Deus, pela vida e pela força que nunca me fez desistir.À Professora Susana, por ter me recebido como "filho científico" e ser a principal fonte de minha formação acadêmica neste trabalho.A Luiz Marcos Lira pela grande contribuição intelectual na idealização deste trabalho e grande referência, principalmente nos primeiros passos da minha formação no doutorado.Ao professor Roberto Torresi que teve grande participação na minha formação e no desenvolvimento deste trabalho.Ao Vinicius Gonçales por toda força, por todos os ensinamentos e por ter sido uma referência para todos no laboratório.Ao Professor Tom Lindfors e a todos do Laboratório de Química Analítica da Universidade Abo Akademi, Turku-Finlândia, por terem me recebido muito bem e pela grande contribuição científica a mim e a este trabalho.À Layane Souza pelo profissionalismo e grande contribuição para este trabalho.A Adriana Campos, José Ricardo, Thiago Selva, Cláudia Sá e demais amigos por todo o esforço para me ajudar a estar aqui terminando este trabalho;Ao Nedher Ramirez e a todos do Centro da Vila Mariana pelos aprendizados e pela força.A toda instituição USP, em especial ao Instituto de Química, pelo qual agradeço a todos os professores e funcionários; Ao Laboratório de Materiais Eletroativos, em especial à Aline Souza pelo profissionalismo e dedicação ao trabalho;A todos os colegas e amigos do Laboratório de Materiais Eletroativos e do IQ-USP por terem deixado minha estadia aqui bem agradável e familiar. Cito ainda, o pessoal do futebol: "Areião" e do IQ-USP.Às agências financiadoras FAPESP (nos processos 2010/17511-0 e 2013/08370-1) e Capes pelas bolsas concedidas.Aos meus pais, meus irmãos, minha avó e toda minha família.E por fim, um agradecimento especial à Kellyda Cinnara, por quem lutei todos os dias nesta caminhada, em nome de nosso amor e por tudo que ela representa para mim. Esta tese está voltada ao estudo da síntese e caracterização de hidro-esponjas de polímeros condutores estruturados sob a ação do agente molde de alaranjado de metila.A síntese destas hidro-esponjas foi realizada tanto quimicamente quanto eletroquimicamente. Na síntese química, destacam-se as hidro-esponjas de polipirrol, onde os estudos de eletrointumescimento realizados em meio aquoso, tanto a nível macroscópico (via variação de volume) quanto a nível molecular (via FTIR-ATR), mostraram que o material se comporta como um hidrogel apresentando alta capacidade de sofrer uma expansão de volume (um aumento de até 40%) e absorver grandes quantidades de água. No que se refere à síntese eletroquímica, destacam-se os filmes finos de hidro-esponja de polipirrol e ...

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Development of a Controlled Release System for Risperidone Using Polypyrrole: Mechanistic Studies

Cited by 48 publications

References 25 publications

A detailed insight into drug delivery from PEDOT based on analytical methods: Effects and side effects

A detailed insight into drug delivery from PEDOT based on analytical methods: Effects and side effects

Electrically controlled release of insulin using polypyrrole nanoparticles

Síntese e caracterização de hidro-esponjas de polímeros condutores

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