Development of a 3D disposable device for the electrochemical determination of diclofenac in different matrices

Lisboa, Thalles Pedrosa; Oliveira, Wallace Burger Veríssimo de; Souza, Cassiano Cunha de; Oliveira, Raylla Santos; Matos, Maria Auxiliadora Costa; Matos, Renato Camargo

doi:10.1007/s00216-022-04414-8

Cited by 9 publications

(1 citation statement)

References 41 publications

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“…Thus, the determination of the DIC trace levels in the biological and pharmaceutical samples is crucial for development and treatment. To date, a wide range of methods have been employed to detect DIC in different kinds of materials such as spectrophotometry [ 4 , 5 ], fluorimetry [ 6 ], HPLC [ 7 , 8 ], GCMS [ 9 , 10 ], LCMS [ 11 ] electrokinetic chromatography [ 12 ], TLC [ 13 ], and electrochemical methods [ 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ]. Among these numerous analytical techniques, the electrochemical approaches might be thought of as the best ones for DIC measurement in solutions since they are sensitive, selective, cheap, and simple to use.…”

Section: Introductionmentioning

confidence: 99%

A Novel Electrochemical Sensor Based on an Environmentally Friendly Synthesis of Magnetic Chitosan Nanocomposite Carbon Paste Electrode for the Determination of Diclofenac to Control Inflammation

et al. 2023

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A simple and eco-friendly electrochemical sensor for the anti-inflammatory diclofenac (DIC) was developed in a chitosan nanocomposite carbon paste electrode (M-Chs NC/CPE). The M-Chs NC/CPE was characterized with FTIR, XRD, SEM, and TEM for the size, surface area, and morphology. The produced electrode showed a high electrocatalytic activity to use the DIC in 0.1 M of the BR buffer (pH 3.0). The effect of scanning speed and pH on the DIC oxidation peak suggests that the DIC electrode process has a typical diffusion characteristic with two electrons and two protons. Furthermore, the peak current linearly proportional to the DIC concentration ranged from 0.025 M to 4.0 M with the correlation coefficient (r2). The sensitivity, limit of detection (LOD; 3σ), and the limit of quantification (LOQ; 10σ) were 0.993, 9.6 µA/µM cm2, 0.007 µM, and 0.024 µM, respectively. In the end, the proposed sensor enables the reliable and sensitive detection of DIC in biological and pharmaceutical samples.

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