Simultaneous monitoring of amoxicillin and paracetamol in synthetic biological fluids using a 3D printed disposable electrode with a lab-made conductive filament

Lisboa, Thalles Pedrosa; de Faria, Lucas Vinícius; de Oliveira, Wallace Burger Veríssimo; Oliveira, Raylla Santos; de Souza, Cassiano Cunha; Matos, Maria Auxiliadora Costa; Dornellas, Rafael Machado; Matos, Renato Camargo

doi:10.1007/s00216-023-05009-7

Cited by 1 publication

(1 citation statement)

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“…The results were compared to those obtained with other 3D-printed devices and electrodes. The effect of MW-induced activation in a kitchen microwave oven is similar (2.84 μM by DPV method) to the effect obtained using an electrochemical cell-on-a-chip device fabricated entirely by 3D printing [ 63 , 64 ]. Meanwhile, the use of CB-PLA filament and microwave activation allows for detection limits only one level lower (0.5 μM by the DPV method) than that which is possible for electrodes fabricated with PLA/graphene filament, which is not commercially available [ 64 ].…”

Section: Resultsmentioning

confidence: 61%

Microwave-Induced Processing of Free-Standing 3D Printouts: An Effortless Route to High-Redox Kinetics in Electroanalysis

Kozłowska,

Cieślik,

Koterwa

et al. 2024

Materials

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3D-printable composites have become an attractive option used for the design and manufacture of electrochemical sensors. However, to ensure proper charge-transfer kinetics at the electrode/electrolyte interface, activation is often required, with this step consisting of polymer removal to reveal the conductive nanofiller. In this work, we present a novel effective method for the activation of composites consisting of poly(lactic acid) filled with carbon black (CB-PLA) using microwave radiation. A microwave synthesizer used in chemical laboratories (CEM, Matthews, NC, USA) was used for this purpose, establishing that the appropriate activation time for CB-PLA electrodes is 15 min at 70 °C with a microwave power of 100 W. However, the usefulness of an 80 W kitchen microwave oven is also presented for the first time and discussed as a more sustainable approach to CB-PLA electrode activation. It has been established that 10 min in a kitchen microwave oven is adequate to activate the electrode. The electrochemical properties of the microwave-activated electrodes were determined by electrochemical techniques, and their topography was characterized using scanning electron microscopy (SEM), Raman spectroscopy, and contact-angle measurements. This study confirms that during microwave activation, PLAs decompose to uncover the conductive carbon-black filler. We deliver a proof-of-concept of the utility of kitchen microwave-oven activation of a 3D-printed, free-standing electrochemical cell (FSEC) in paracetamol electroanalysis in aqueous electrolyte solution. We established satisfactory limits of linearity for paracetamol detection using voltammetry, ranging from 1.9 μM to 1 mM, with a detection limit (LOD) of 1.31 μM.

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Section: Resultsmentioning

confidence: 61%