Development of 9-(N-arylmethylamino) congeners of noscapine: the microtubule targeting drugs for the management of breast cancer

Design, Synthesis, and Functional Studies on Noscapine and Cotarnine Amino Acid Derivatives as Antitumor Agents

“…Previous investigations disclosed that noscapine and its analogues induced apoptosis in many tumor cell types. ,− To determine whether the induction of apoptosis is responsible for the antiproliferative property of noscapine analogues, we assessed the induction of apoptosis in 4T1 mammary carcinoma tumor cells using annexin V and propidium iodide (PI) staining. As indicated in Figure , the percentage of cells undergoing apoptosis was 33.3% in noscapine-treated cells.…”