Development, Innervation, and Activity-Pattern Induced Changes in Skeletal Muscle

Jólesz, Ferenc A.; Sreter, F. A.

doi:10.1146/annurev.ph.43.030181.002531

Cited by 314 publications

(100 citation statements)

References 86 publications

(147 reference statements)

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“…In adult muscles, the induction of slow myosin appears to be a nerve-dependent process [29]. The role of the nerve may be to impose a continuous pattern of activity on the muscle; when this is done experimentally, both heavy and light chains of slow myosin will accumulate in a previously fast muscle [30,31].…”

Section: Discussionmentioning

confidence: 99%

A developmentally regulated disappearance of slow myosin in fast‐type muscles of the mouse

et al. 1984

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Histochemistry and immunocytochemistry using an antibody to adult rat slow-type myosin demonstrated that about 10% of the fibers in the mouse extensor digitorum longus and semimembranosus muscles contain slow myosin during the first month after birth. In adult animals, these muscles have only t&0.8% slow myosin-containing fibers. These results demonstrate a developmentally linked disappearance of an adult-type myosin, and show that the adult phenotype of muscle fibers is not necessarily determined before birth as previously suggested. Histochemistry Immunocytochemistry

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Section: Discussionmentioning

confidence: 99%

A developmentally regulated disappearance of slow myosin in fast‐type muscles of the mouse

et al. 1984

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“…The concomitant de novo perinatal expression of slow MHC and elimination of fast MHC in a subpopulation of secondary fibers in the direct vincinity of primary fibers could be neurally regulated. Indeed, it is generally assumed that muscle fibers undergo a neurally independent preprogrammed sequence of myosin transitions towards the fast phenotype (Embryonic + Neonatal -+ Fast) unless they receive a neural signal which will switch the programme towards the accumulation and maintenance of slow myosin, while inhibiting fast myosin synthesis (Salmons and Henriksson, 1981;Jolesz and Sreter, 1981;Butler-Browne et al, 1982;Condon et al, 1990b;Gambke et al, 1983;. The neural mechanisms leading to the formation of the islets of type I fibers are not understood, we only know that it is not due to the collateral branching of axons to innervate adjacent fibers (Beermann et al, 1978).…”

Section: A Subpopulation Of Secondary Fibers Starts To Express Slow Mmentioning

confidence: 99%

Pattern of muscle fiber type formation in the pig

Lefaucheur¹,

Edom

Ecolan³

et al. 1995

Developmental Dynamics

139

120

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The aim of this study was to analyze the temporal sequence of expression of the myosin isoforms in the populations of muscle fibers in the pig and to bring more information on the origin of the strikingly different pattern of fiber composition and distribution between the deep medial red (oxido-glycolytic) and superficial white (glycolytic) portions of semitendinosus (ST) muscle. Muscle samples were taken from 49-, 55-, 75-, 90-, 103-, and 113-(birth) day-old fetuses, from 6-, 11-, 21-, 35-, 50-, and 80-day-old piglets, and from a 3-year-old pig. Our results confirm the sequential formation of primary and secondary generation fibers. The use of immunohistochemistry and heterologous monoclonal antibodies (mAb) directed against specific myosin heavy chain (MHC) isoforms revealed a different pattern of gene expression between the two portions of the ST muscle for both generations of fibers. By 75 days of gestation (dg), primary myotubes from the deep medial portion stained positively for the anti-slow MHC mAb and negatively for the adult anti-fast MHC, whereas the opposite was observed in the superficial portion. Secondary fibers never expressed slow MHC until late gestation. Instead, they expressed an adult fast MHC isoform as soon as they formed in the deep medial portion and later on in the superficial portion. From late gestation to the first 3 postnatal weeks, slow MHC began to be expressed in a subpopulation of secondary fibers. These fibers were in the direct vicinity of primary myotubes in the deep medial portion, whereas their location could not be established in the superficial portion. The remaining secondary fibers matured to type IIA in the direct vicinity of these type I fibers and to type IIB at the periphery of the islets. In both portions of the muscle, a subpopulation of secondary fibers, the first ones to express slow MHC, also transitorily expressed a MHC that was identical or closely related to the a-cardiac MHC during the early postnatal period. A third generation of small diameter fibers was observed shortly after birth and reacted with the anti-fetal MHC mAb; their destiny remains to be established. The present work reveals a remarkable pattern of MHC gene expression in the pig and raises many questions on the real nature of these isoforms. In order to answer these questions, we have undertaken to make a cDNA library of pig skeletal muscle and to screen 0 1995 WILEY-LISS, INC.this library with the same mAbs used in the present study. o 1995 Wiley-Liss, Inc.

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“…This atrophy is associated with a decrease in tension-producing capacity, which is greater than that predicted by the reduction in muscle weight, suggesting a decrease in the contractile efficiency of tenotomized muscle (Eccles, 1944;Buller & Lewis, 1965 b;Nelson, 1969). Rapid recovery of morphological characteristics accompanies tendon reattachment (McMinn & Vrbova, 1964;Jolesz & Sreter, 1981).…”

Section: Introductionmentioning

confidence: 99%

The effect of immobilization on the recovery of rabbit soleus muscle from tenotomy: modulation by chronic electrical stimulation

Barry¹,

Ma²,

Cameron³

et al. 1994

Experimental Physiology

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SUMMARYThe effect of unilateral Achilles' tendon section on the soleus muscle of rabbits was examined after 2 and 4 weeks of unsutured recovery. Immobilization of the limb during recovery was also investigated. Following tendon section the limb was immobilized with an ankle angle of 90 deg, and final experiments were performed either after 2 weeks, or after the splints were removed and a further 2 weeks recovery allowed. Remobilized recovery was either allowed to occur naturally or with chronic low-frequency electrical stimulation of the soleus nerve. Achilles' tendon section resulted in very little change in the morphological profile of the soleus, but a marked decrease in tension production. Two weeks following tenotomy, tetanic tension was reduced to 50 % of normal; this reduction persisted for the following 2 weeks of recovery. Imposition of immobilization after tendon section produced gross degeneration of the soleus. The fibres that remained had a mean fibre area of 20 % of control values and displayed an immature staining pattern. This was accompanied by a reduction in tension production to less than 5 % of normal and a marked speeding of contraction. Two weeks of passive recovery following splint removal slowed contraction and improved both the morphological profile and tension production of the soleus. Application of stimulation during this time restored contraction times to normal, reflecting the return to normal fibre-type proportions of this group, and improved the morphological profile and tension production beyond that of the unstimulated group. Thus immobilization worsened considerably the alterations occurring in the morphological and physiological properties of the soleus following Achilles' tendon section. Upon remobilization, chronic stimulation accelerated recovery of both parameters.

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Development, Innervation, and Activity-Pattern Induced Changes in Skeletal Muscle

Cited by 314 publications

References 86 publications

A developmentally regulated disappearance of slow myosin in fast‐type muscles of the mouse

A developmentally regulated disappearance of slow myosin in fast‐type muscles of the mouse

Pattern of muscle fiber type formation in the pig

The effect of immobilization on the recovery of rabbit soleus muscle from tenotomy: modulation by chronic electrical stimulation

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