Development characterization and skin permeating potential of lipid based novel delivery system for topical treatment of psoriasis

Design, Formulation, and Characterization of Stearic Acid-Based Solid Lipid Nanoparticles of Candesartan Cilexetil to Augment Its Oral Bioavailability

“…SLNs were prepared by "modified emulsification-ultrasonication method" [37,38]. Briefly, the lipid phase was prepared by dissolving stearic acid and the drug in 10 ml of methanol and heating at 70°C (temperature above melting point of the lipid).…”

Optimization of nanostructured lipid carriers loaded with methotrexate: A tool for inflammatory and cancer therapy

“…To reach an optimized formulation using traditional screening approach (one factor at a time) is difficult, inefficient and time consuming. A few studies (Cun et al, 2011;Liu et al, 2010;Pradhan et al, 2015) have optimized lipid nanoparticles using factorial design and is widely accepted that the ingredients have great influence on the physico-chemical properties (Hao et al, 2011). The statistical formulation design is a validated and useful approach to develop a formulation with less experimentation and providing enough information on the relationship between independent and dependent variables (Gohel and Amin, 1998;Liu et al, 2010).…”

Ivermection-loaded solid lipid nanoparticles: preparation, characterisation, stability and transdermal behaviour

“…Meanwhile, small sized lipid particles ensures close association with stratum corneum [12], thus increasing the quantity of the drug penetrating into the skin. The SLNs seem to be well suited for application on damaged or inflamed skin [13], hence they have been used for improving the skin/dermal uptake of several drugs, such as penciclovir, isotretinoin, fluocinolone acetonide and fluconazole [14][15][16][17], supporting the fact that the SLNs may be employed as a topical delivery system for IVM.…”