Development and Validation of Selective Spectrophotometric Methods for the Determination of Pregabalin in Pharmaceutical Preparation

Önal, Armağan

doi:10.1002/cjoc.200990130

Cited by 14 publications

(8 citation statements)

References 24 publications

(11 reference statements)

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“…At TCNQ concentration less than 50 µg mL −1 the absorbance was very less but there was severe interference from the background at TCNQ concentration more than 200 µg mL −1 . TCNQ is a strong π-acceptor; n-π or π-π charge transfer complexes have been reported for determination of many compounds [16,17]. TXA, attributed to amino acid derivative agent, has one electron rich amino group, which may form n-π charge-transfer complex with TCNQ at the same time [18].…”

Section: Resultsmentioning

confidence: 99%

Spectrophotometric study of the charge transfer complexation of tranexamic acid with 7,7,8,8-tetracyanoquinodimethane

Sheng-Yun¹,

Hou²

2014

Bull. Chem. Soc. Eth.

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ABSTRACT. A simple, sensitive and accurate spectrophotometric method for the determination of tranexamic acid (TXA) has been developed. The method was based on the charge transfer reaction between TXA as n-electron donor and 7,7,8,8-tetracyanoquinodimethane (TCNQ) asacceptor resulting in highly coloured stable complex, which showed maximum absorption band at wavelength of 419 nm. The formation of such complex was also confirmed by infrared measurement. The stoichiometry of the complex was found to be 1:1 between donor and acceptor as determined by Job's continuous variation method and straight line method. The thermodynamic parameters were calculated as association constant KCT of 5109 mol −1 and Gibbs free energy ∆G° of 22.22 kJ mol −1 . Different variables affecting the CT reaction were carefully studied and optimized. At the optimum reaction conditions, Beer's law was obeyed in a concentration range of 1−18 µg mL −1 of TXA using TCNQ reagent and the limit of detection was 0.2 µg mL −1 . Different analytical parameters, namely molar absorptivity (ε), relative standard deviation, correlation coefficient, limit of detection, and Sandell sensitivity, were calculated. The developed method could be applied successfully for the determination of TXA in its pharmaceutical dosage forms with a good precision and accuracy compared to the official method.

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Section: Resultsmentioning

confidence: 99%

Spectrophotometric study of the charge transfer complexation of tranexamic acid with 7,7,8,8-tetracyanoquinodimethane

Sheng-Yun¹,

Hou²

2014

Bull. Chem. Soc. Eth.

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“…14,15 The studied drug, attributed to amino acid derivative agent, has one electron rich group of amino, which may form n-π CT complex with TCNQ at the same time. 4 The drug is probably through the lone pair of electron donated by the N atom in the amino (n-electron donor) to TCNQ (π-electron acceptor).…”

Section: Discussion Of Reaction Mechanismmentioning

confidence: 99%

Study of Spectrophotometric Characteristics of the Charge Transfer Reaction of Aminomethylbenzoic Acid with 7,7,8,8-Tetracyanoquinodimethane

Li¹,

Song²,

Hou³

et al. 2011

Chin. J. Chem.

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A new spectrophotometric method was developed for the determination of aminomethylbenzoic acid (PAMBA) using 7,7,8,. The method was based on the formation of charge transfer (CT) complex of this drug as n-electron donor with the π-acceptor TCNQ. TCNQ was found to react with PAMBA to produce a kind of yellow complex. The CT reaction proceeded quantitatively in pH 8.5 buffer solution. Different variables affecting the reaction were carefully studied and optimized. Under optimal reaction conditions, the stoichiometric ratio of the reaction, maximum absorption wavelength and the value of molar absorptivity were measured to be 1∶1, 425 nm, and 1.9×104 L•mol -1 •cm -1 , respectively. Beer's law was obeyed in the range of 1-9 µg•mL −1 of PAMBA. The data have been filled to a linear regression equationwith a correlation coefficient of 0.9996. The detection limit was 0.4 µg•mL -1 , R.S.D. was less than 1.9%, and average recovery was over 97.6%. The formation of the CT complex was also confirmed by both infrared and 1 H NMR measurements. The thermodynamic property, kinetic property and reaction mechanism have also been discussed. The method developed was applied successfully to the determination of the subject drug in its pharmaceutical dosage forms with good precision and accuracy compared to official method revealed by t-and F-tests.

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“…Onal [12] described three simple, quick and sensitive methods for the spectrophotometric determination of PGB in pharmaceutical preparations. Among them, the first two methods were based on the reaction of PGB as n-electron donors with 2,3-dichloro-5,6-dicyano-1,4benzoquinone (DDQ) and 7,7,8,8tetracyanoquinodimethane (TCNQ) as π-acceptors to give highly colored complex species.…”

Section: Spectrophotometric Methodmentioning

confidence: 99%

Recent advances in analytical techniques for the determination of pregabalin in pharmaceutical and biological samples

Liu¹,

Dong²

2016

Int. J. Curr. Res. Chem. Pharm. Sci

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Pregabalin (PGB), is an antiepileptic and analgesic drug, which is structural analogue of γ-amino-butyric acid. This drug has been approved by Food and Drug Administration for the treatment of central nervous system disorders including epilepsy, fibromyalgia and also for the treatment of neuropathic pain. It was designed as a potent successor to gabapentin. PGB is minimally metabolized and primarily excreted through urine in an unchanged form. It has predictable pharmacokinetics with excellent bioavailability and has minimal binding to serum proteins. Therefore, determination the content of pregabalin is very important. In this article the studies of detection methods for pregabalin in recent years are reviewed.

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Development and Validation of Selective Spectrophotometric Methods for the Determination of Pregabalin in Pharmaceutical Preparation

Cited by 14 publications

References 24 publications

Spectrophotometric study of the charge transfer complexation of tranexamic acid with 7,7,8,8-tetracyanoquinodimethane

Spectrophotometric study of the charge transfer complexation of tranexamic acid with 7,7,8,8-tetracyanoquinodimethane

Study of Spectrophotometric Characteristics of the Charge Transfer Reaction of Aminomethylbenzoic Acid with 7,7,8,8-Tetracyanoquinodimethane

Recent advances in analytical techniques for the determination of pregabalin in pharmaceutical and biological samples

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