Recent advances in analytical techniques for the determination of pregabalin in pharmaceutical and biological samples

Abstract

Pregabalin (PGB), is an antiepileptic and analgesic drug, which is structural analogue of γ-amino-butyric acid. This drug has been approved by Food and Drug Administration for the treatment of central nervous system disorders including epilepsy, fibromyalgia and also for the treatment of neuropathic pain. It was designed as a potent successor to gabapentin. PGB is minimally metabolized and primarily excreted through urine in an unchanged form. It has predictable pharmacokinetics with excellent bioavailability and has minimal binding to serum proteins. Therefore, determination the content of pregabalin is very important. In this article the studies of detection methods for pregabalin in recent years are reviewed.