Development and validation of HPLC method for determination of indomethacin and its two degradation products in topical gel

Nováková, Lucie; Matysová, Ludmila; Havlíková, Lucie; Solich, Petr

doi:10.1016/j.jpba.2004.09.012

Cited by 46 publications

(27 citation statements)

References 16 publications

(18 reference statements)

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“…Indomethacin is an anti-inflammatory drug used to reduce fever, pain, stiffness and swelling by inhibition of the production of prostaglandins, compounds that cause these problems. From the decomposition of indomethacin arises 5-methoxy-2-methylindoleacetic acid and the same quantity of 4-CBA [5]. In the case of antidepressant bupropion just small amount (0.3%) of 3-CBA is formed next to threohydrobupropion, erythrohydrobupropion and hydroxybupropion [6,7].…”

Section: Introductionmentioning

confidence: 99%

Bioremediation of Chlorobenzoic Acids

Vrchotová¹,

Macková²,

Macek³

et al. 2013

Applied Bioremediation - Active and Passive Approaches

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Section: Introductionmentioning

confidence: 99%

Bioremediation of Chlorobenzoic Acids

Vrchotová¹,

Macková²,

Macek³

et al. 2013

Applied Bioremediation - Active and Passive Approaches

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“…[1][2][3] Currently many commercial formulations such as tablets, capsules, ointments, gels, have also been reported for analysis of IND in biological fluids. [17][18][19] Several analytical methods like CZE, micellar electrokinetic capillary chromatography (MEKC) [20] , GC [21] , HPLC [21][22][23][24] , phosphorimetry [25] , liquid chromatography-MS (LCMS) [26] , ultrasonic resonator technology, Raman spectroscopy [27] , high performance thin layer chromatography (HPTLC) [2] , spectrophotometric [28] and electrochemical methods [29] were also been reported for analysis of IND and its related impurities & degradation products in pure drug and various pharmaceutical formulations. Raman spectroscopy and dynamic mechanical analysis (DMA) have been reported for analysis of crystalline or amorphous nature of IND.…”

Section: An Environmentally Benign Approach For Rapid Analysis Of Indmentioning

confidence: 99%

An Environmentally Benign Approach for Rapid Analysis of Indomethacin Using a Stability-Indicating Rp-HPLC Method

Haq

Shakeel

Ali

et al. 2014

Journal of Liquid Chromatography & Related Technologies

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Green RP-HPLC method for analysis of indomethacin (IND) in bulk drug, nanoemulsion and various marketed formulations was developed and validated in present investigation.The chromatographic identification was achieved on Lichrosphere 250 X 4.0 mm RP C 8 column having a 5µm packing as a stationary phase using a green solvent ethyl acetate (100 % v/v) as a mobile phase, at a flow rate of 1.0 mL/min with UV detection at 318 nm.The proposed method was validated for linearity, selectivity, accuracy, precision, robustness, sensitivity and specificity. The utility of the method was verified by assay of IND in developed nanoemulsion, marketed tablet, capsule, suppository and injection. The proposed method was found to be selective, precise, accurate, robust, sensitive and specific. The amount of IND in developed nanoemulsion and all marketed formulations ranged from 98.34-101.40 %. The proposed method successfully resoled IND peak in the presence of its degradation products which indicated stability-indicating property of the Downloaded by [Georgetown University] at 23:38 17 September 2013 ACCEPTED MANUSCRIPT ACCEPTED MANUSCRIPT 2 proposed method. These results indicated that the proposed method can be successfully employed for routine analysis of IND in bulk drug and pharmaceutical dosage forms.

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“…The HPLC method was adopted from the literature (Novakova et al, 2005). The RP-HPLC measurements were carried out using a Perkin Elmer series 200 system (Perkin Elmer, Norwalk, CT) consisting of a quaternary pump, an on-line degasser, an auto sampler, a column-heating assembly and a UV detector (Perkin Elmer 785 A UV/Vis).…”

Section: Ind Experimentsmentioning

confidence: 99%

Carbon nanotubes for transdermal drug delivery

Değim

Burgess

Papadimitrakopoulos

2010

Journal of Microencapsulation

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In this study, drug carrier properties through skin and penetration enhancement effects of carbon nanotubes (CNTs) are presented. Multi-walled and double-walled carbon nanotubes were used. Penetration enhancement into the skin following passive diffusion and iontophoresis were determined. Possible solubility enhancement effects and drug adsorption properties of CNTs were investigated. CNTs were found to be a useful drug carrier system and they can provide a high loading and enhanced transdermal penetration for especially hydrophobic drugs. The electroconductive nature of CNTs allows easy application of iontophoresis and the additional advantage of CNTs appears to be using them as electrodes.

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Development and validation of HPLC method for determination of indomethacin and its two degradation products in topical gel

Cited by 46 publications

References 16 publications

Bioremediation of Chlorobenzoic Acids

Bioremediation of Chlorobenzoic Acids

An Environmentally Benign Approach for Rapid Analysis of Indomethacin Using a Stability-Indicating Rp-HPLC Method

Carbon nanotubes for transdermal drug delivery

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