Development and Validation of HPLC–MS/MS Method for the Simultaneous Determination of 8-Hydroxy-2′-deoxyguanosine and Twelve Cosmetic Phenols in Human Urine

Chen, Xueyan; Lu, Shaoyou; Zhi, Tian; Zhu, Zhaojie; Zhong, Weichuan; Li, Kang; Liao, Shicheng

doi:10.1007/s10337-019-03757-2

Cited by 8 publications

(2 citation statements)

References 15 publications

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“…The concentration range of LODs for PCPCs was 2.82–36.36 pg mL −1 and of LOQs was 9.39–121.08 pg mL −1 . The LODs and LOQs obtained by this method were similar to those reported in other studies using traditional extraction techniques combined with UHPLC–MS/MS, such as LLE‐UHPLC–MS/MS 47 and SPE‐UHPLC–MS/MS 26,48 . In general, the method can be considered suitable for quantitative and qualitative analysis of trace PCPC substances in human urine.…”

Section: Resultssupporting

confidence: 82%

“…The concentration range of LODs for PCPCs was 2.82-36.36 pg mL À1 and of LOQs was 9.39-121.08 pg mL À1 . The LODs and LOQs obtained by this method were similar to those reported in other studies using traditional extraction techniques combined with UHPLC-MS/MS, such as LLE-UHPLC-MS/MS47 and SPE-UHPLC-MS/MS 26,48. In general, the T A B L E 1 acid; DLLE, dispersive liquid-liquid extraction; EtP, ethylparaben; LLE, liquid-liquid extraction; LOD, limit of detection; LOQ, limit of quantitation; MeP, methylparaben; OH-EtP, ethyl protocatechuate; PrP, propylparaben; TCC, triclocarban; TCS, triclosan.…”

supporting

confidence: 85%

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A fast method for the determination of personal care product chemicals in human urine using dispersive liquid–liquid extraction and ultra high‐performance liquid chromatography–tandem mass spectrometry

Zheng,

Liu,

Zhang

et al. 2024

Rapid Comm Mass Spectrometry

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RationalePersonal care product chemicals (PCPCs) are the chemicals used in personal care products. Many of them are endocrine disruptors and have potential adverse effects on humans. The concentrations of PCPCs in urine are the main biomarker for assessing human exposure.MethodsA method was developed for the simultaneous determination of 14 PCPCs in human urine using dispersive liquid–liquid extraction combined with ultra high‐performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS).ResultsCompared with liquid–liquid extraction, this method had the advantages of time efficiency, sensitivity, and limited organic solvent consumption. It produced good linearity (0.9965–0.9996), limits of detection (2.82–36.36 pg mL−1), limits of quantitation (9.39–121.08 pg mL−1), matrix effect (−0.90%–2.55%), intra‐day precision (relative standard deviations [RSDs] <15%), and inter‐day precision (RSDs <19.9%). The method had satisfactory relative recovery at three concentration levels.ConclusionsA rapid method was developed for the simultaneous quantification of 14 PCPCs in human urine. The practicability of the method was verified with 21 urine from university students. It is expected that this method will provide a powerful reference for the assessment of exposure to PCPCs in large populations.

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Section: Resultssupporting

confidence: 82%

supporting

confidence: 85%