Development and validation of HPLC methods for enantioseparation of mirtazapine enantiomers at analytical and semipreparative scale using polysaccharide chiral stationary phases

Zhai, Zhongsheng; Shi, Yan‐Ping; Wang, Ting

doi:10.1016/j.aca.2005.06.044

Cited by 28 publications

(18 citation statements)

References 24 publications

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“…[7,8,[10][11][12] However, in view of the significant changes in surface area and pore size in the present study, an investigation was carried out to determine the optimum level of the cellulose carbamate coating on APS with a pore size of 27 nm.…”

Section: Optimum Load Amount Of Cdmpc On Apsmentioning

confidence: 99%

The Influence of Coating Thickness of Polymer on Chiral Discrimination of Cellulose Tris(3,5-Dimethyl Phenylcarbamate) Chiral Stationary Phase

Chen

Wang

Liu

et al. 2009

International Journal of Polymer Analysis and Characterization

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The influence of the coating thickness of the polymer on the chiral discrimination of cellulose tris(3,5-dimethyl phenylcarbamate) (CDMPC) chiral stationary phase (CSP) is investigated. CDMPC-CSPs with different thicknesses of polymer were prepared, and their chromatographic performances were investigated. Thinner coat of polymer will increase the interactions between the samples and the support of CSPs and decrease the selectivity of CSPs. Too thick coat of polymer will not increase the performance of CSPs significantly but will decrease the performance of the column. The suited thickness of polymer is very important for the selectivity of the chiral stationary phase.

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Section: Optimum Load Amount Of Cdmpc On Apsmentioning

confidence: 99%

The Influence of Coating Thickness of Polymer on Chiral Discrimination of Cellulose Tris(3,5-Dimethyl Phenylcarbamate) Chiral Stationary Phase

Chen

Wang

Liu

et al. 2009

International Journal of Polymer Analysis and Characterization

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“…This is in accordance with what can be observed in HPLC. In fact, some enantioselective methods for antidepressants by HPLC or nano-LC report the use of CSPs containing carbohydrates in one form or another (such as cellulose and amylose) [53][54][55] (Cannazza, G. et al, J. Pharmazeut. Biomed., submitted) or of carbohydrates as mobile phase additives [56] and some use a vancomycinmodified stationary phase [57][58][59].…”

Section: Discussionmentioning

confidence: 99%

Electrodriven methods for the enantioseparation of second‐generation antidepressant drugs: An update

Mandrioli

Raggi

2007

Electrophoresis

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Second-generation antidepressant drugs are increasingly prescribed world-wide by psychiatrists and primary care physicians. Generally speaking, they seem to be safer than traditional tricyclic antidepressant drugs, especially in overdose. However, most of them possess stereogenic centers, thus they can exist as enantiomeric couples. Since enantiomers can have even dramatically different pharmacokinetic and pharmacodynamic properties, the study of antidepressant chirality is of great importance. In fact, the application of enantioselective analytical techniques can be useful both for the quality control of enantiomerically pure formulations and for the pharmacovigilance and therapeutic monitoring of patients undergoing treatment with these drugs. The high efficiency and inexpensiveness of electrodriven methods makes them a very attractive alternative to the usual chromatographic methods. This review is an update (2004-2007) of a previously published paper on recent electrodriven methods for the enantioseparation of second-generation antidepressants. In particular, the focus has been put on selective serotonin reuptake inhibitors such as citalopram and sertraline, noradrenergic and specific serotonergic antidepressants, such as mirtazapine and tetracyclic antidepressants such as mianserin, as well as on multianalyte methods.

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“…RP-HPLC [4,5] and LC-MS/MS [6] with electrospray ionization were extensively used for analysis of antidepressants including MTZ and DMTZ in plasma. Analytical and semi preparative separation of enantiomers of MTZ and its metabolites were carried out on various polysaccharide chiral stationary phases by LC [7]. Santana et al studied the chromatographic separation of (+)-(S)-and (−)-(R)-enantiomers of MTZ on Chiralpak AD column [8].…”

Section: Mirtazapinementioning

confidence: 99%

Enantiomeric separation of mirtazapine and its metabolite in rat plasma by reverse polar ionic liquid chromatography using fluorescence and polarimetric detectors connected in series

Rao

Katragunta

Sistla

2011

Journal of Chromatography B

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Development and validation of HPLC methods for enantioseparation of mirtazapine enantiomers at analytical and semipreparative scale using polysaccharide chiral stationary phases

Cited by 28 publications

References 24 publications

The Influence of Coating Thickness of Polymer on Chiral Discrimination of Cellulose Tris(3,5-Dimethyl Phenylcarbamate) Chiral Stationary Phase

The Influence of Coating Thickness of Polymer on Chiral Discrimination of Cellulose Tris(3,5-Dimethyl Phenylcarbamate) Chiral Stationary Phase

Electrodriven methods for the enantioseparation of second‐generation antidepressant drugs: An update

Enantiomeric separation of mirtazapine and its metabolite in rat plasma by reverse polar ionic liquid chromatography using fluorescence and polarimetric detectors connected in series

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