Development and validation of an analytical method for the simultaneous estimation of Etoricoxib and Thiocolchicoside in tablet dosage form by UV Spectrophotometric method

Kumari, Niraj; Chaudhary, Amit; Verma, Kapil Kumar; Verma, Kritika; Saini, Geetanjali; Vyas, M. D.; Singh, Bhupendra

doi:10.52711/0974-360x.2022.00510

Cited by 2 publications

(2 citation statements)

References 10 publications

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“…and U.S.P. 12,13 Comparison of percentage purity between standard and samples using UV-spectrophotometric method was recorded According to British Pharmacopoeia, the percentage purity of Lisinopril should be in the range of 92.5% and 105%. 9 Thus, only Brand A and Brand C passed the test while Brand B failed the test.…”

Section: Discussionmentioning

confidence: 99%

Quantitative determination by UV spectroscopy, structural characterization evaluation by Fourier Transform Infrared Spectroscopy (FTIR) and disintegration analysis of Lisinopril tablets available in the Malaysian outlets

Perveen,

Jia Min,

Hasan Khan

2023

PPIJ

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Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor that is widely used in the treatment of heart diseases and hypertension.Objectives: To compare the percentage purity of several brands of Lisinopril tablets available in the Malaysian Outlets by the UV spectrophotometric and the Fourier-Transform Infrared Spectroscopic methods (FTIR) and to evaluate the time taken for each brand of Lisinopril tablets to dissolve during disintegration analysis. Method:For UV spectrophotometric method, different brands of Lisinopril tablets were diluted with distilled water and undergone a series of dilutions. The absorbance of the diluted sample solutions were measured using a UV spectrometer. The absorbance revealed the concentration of Lisinopril in the sample solution. For FTIR method, the different brands of Lisinopril powders were placed on the diamond crystal plate and pressure was applied. The spectrum of each brand was measured using FTIR spectrometer. The spectrum revealed the functional group of each Lisinopril brand and compared their purity.Results: For UV spectrophotometric method, only Brand A and C were within the limit specified by B.P. and U.S.P. For FTIR method, structural characterization of all brands of Lisinopril tablets was identified. Conclusion:It was concluded that Brand A was the best among 3 brands of Lisinopril used in this research.

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Section: Discussionmentioning

confidence: 99%

Quantitative determination by UV spectroscopy, structural characterization evaluation by Fourier Transform Infrared Spectroscopy (FTIR) and disintegration analysis of Lisinopril tablets available in the Malaysian outlets

Perveen,

Jia Min,

Hasan Khan

2023

PPIJ

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“…17 Different analytical techniques were reported for the quantification of this drug and the impurities arising during its manufacturing process. [18][19][20][21] However, no LC-MS/MS approach for determining the process impurity Vinamidinium Hexafluorophosphate was disclosed. Finally, we will work on establishing a suitable method for detecting impurities by employing LC-MS/MS.…”

Section: Introductionmentioning

confidence: 99%

LC-MS/MS Analytical Method Development and Validation for Determining Vinamidinium HexafluoroPhosphate Impurity in Etoricoxib

Ganta¹,

Rao²,

Srinivas³

et al. 2023

Ind. J. Pharm. Edu. Res.

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Background and Aim: Process impurities may adversely affect the efficacy, excellent quality, and safety of pharmaceutical drugs. Ultimately, the purpose of this research work was to develop and validate a LC-MS/MS-based method for determining the Vinamidinium hexafluorophosphate impurity (VHP) in Etoricoxib in a simple, specific, accurate, and precise manner. Materials and Methods: To elute the Vinamidinium hexafluorophosphate impurity in Etoricoxib at a flow rate of 0.5mL/min within 20.0 min of runtime, a Symmetry Shield RP18, 5µm column with a 150 x 3.9 mm internal diameter was utilized in binary gradient mode. The buffer solution, which contained formic acid (0.1%) and acetonitrile (100%), as well as a diluent solution of acetonitrile (50%) and water (50%), was used to achieve the chromatographic separation. A triple quadrupole mass spectrometer (Shimadzu LC/MS/MS 8040) in Multiple Reaction Monitoring (MRM) mode was needed to monitor the results. Results and Discussion: The method's linearity was evaluated at levels from 25% to 150%, and the R 2 value was discovered to be 0.99. Sensitivity values of 0.04µg/g (LOD) and 0.13µg/g (LOQ) were established. The recovery of impurity levels of Vinamidinium hexafluorophosphate ranges from 70.0% to 130%. Linearity, specificity, accuracy, LOD, LOQ, and precision of the method were all validated. Within the assay variability limitations, it was found that the intra-and inter-day precision values were 0.67%, and 0.58%, respectively. Conclusion: According to ICH and FDA specifications, the optimized method was validated. The developed method was found to be appropriate for quantifying Vinamidinium hexafluorophosphate in Etoricoxib by employing LC-MS.

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Development and validation of an analytical method for the simultaneous estimation of Etoricoxib and Thiocolchicoside in tablet dosage form by UV Spectrophotometric method

Cited by 2 publications

References 10 publications

Quantitative determination by UV spectroscopy, structural characterization evaluation by Fourier Transform Infrared Spectroscopy (FTIR) and disintegration analysis of Lisinopril tablets available in the Malaysian outlets

Quantitative determination by UV spectroscopy, structural characterization evaluation by Fourier Transform Infrared Spectroscopy (FTIR) and disintegration analysis of Lisinopril tablets available in the Malaysian outlets

LC-MS/MS Analytical Method Development and Validation for Determining Vinamidinium HexafluoroPhosphate Impurity in Etoricoxib

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