Quantitative determination by UV spectroscopy, structural characterization evaluation by Fourier Transform Infrared Spectroscopy (FTIR) and disintegration analysis of Lisinopril tablets available in the Malaysian outlets

Abstract

Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor that is widely used in the treatment of heart diseases and hypertension.Objectives: To compare the percentage purity of several brands of Lisinopril tablets available in the Malaysian Outlets by the UV spectrophotometric and the Fourier-Transform Infrared Spectroscopic methods (FTIR) and to evaluate the time taken for each brand of Lisinopril tablets to dissolve during disintegration analysis. Method:For UV spectrophotometric method, different brands of Lisinopril tablets were diluted with distilled water and undergone a series of dilutions. The absorbance of the diluted sample solutions were measured using a UV spectrometer. The absorbance revealed the concentration of Lisinopril in the sample solution. For FTIR method, the different brands of Lisinopril powders were placed on the diamond crystal plate and pressure was applied. The spectrum of each brand was measured using FTIR spectrometer. The spectrum revealed the functional group of each Lisinopril brand and compared their purity.Results: For UV spectrophotometric method, only Brand A and C were within the limit specified by B.P. and U.S.P. For FTIR method, structural characterization of all brands of Lisinopril tablets was identified. Conclusion:It was concluded that Brand A was the best among 3 brands of Lisinopril used in this research.