Development and validation of an assay method for benzene in the delgocitinib drug substance using conventional HPLC

Nomura, Shinkichi; Ito, Yoshiharu; Takegami, Shigehiko; Kitade, Tatsuya

doi:10.1007/s11696-018-0608-2

Cited by 3 publications

(4 citation statements)

References 11 publications

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“…1,2 Benzene is highly toxic, volatile, and carcinogenic. 3 The long-term exposure to benzene is closely related to some types of blood cancers. 4 Benzene is also flammable, and fire and explosion may occur due to the release of benzene from a pipe, tank, and reactor.…”

Section: Introductionmentioning

confidence: 99%

“…The Areal Locations of Hazardous Atmospheres (ALOHA) approach is one of the best consequence prediction tools to model hazard distance resulting from various chemical release scenarios, and it is practical for risk-based emergency response for the surrounding human beings and environments. 8,9 In this article, therefore, a large-scale benzene storage tank with a capacity of 4000m 3 in an existing chemical enterprise under different seasons was modeled using the ALOHA program to determine the effects and consequences of benzene release. The findings of this research provide a better understanding of the risk of large-scale benzene storage and the scientific support for the safety management and emergency response.…”

Section: Introductionmentioning

confidence: 99%

“…Research has shown that benzene is one of the most dangerous of organic pollutants released in production sites 1,2 . Benzene is highly toxic, volatile, and carcinogenic 3 . The long‐term exposure to benzene is closely related to some types of blood cancers 4 .…”

Section: Introductionmentioning

confidence: 99%

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Accident consequence assessment of benzene leakage from storage tank in a chemical park in Bengbu City, China

Zhou

Chen²,

et al. 2023

Process Safety Progress

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Benzene is widely used in chemical industries and has a high potential to cause damage. The release of benzene from storage tanks can generate threats to workers, facilities, and the environment. The effects and consequences of benzene release from a storage tank during the dry and rainy seasons were investigated with the Areal Locations of Hazardous Atmospheres (ALOHA) software program. Risk distributions were obtained through threat zones classified by red, orange, and yellow colors. The results showed that the maximum hazard areas related to benzene vapor cloud and flammability in rainy seasons were greater than those in the dry seasons. There was no significant difference in the consequences of the thermal radiation from pool fire and the Boiling Liquid Expanding Vapor Explosion (BLEVE) scenario in both the rainy and dry seasons. The maximum threat zones were determined to be 2200 and 305 m for the toxic benzene vapor cloud and the flammable area, respectively. The consequences of the pool fire and BLEVE scenario of benzene were at a distance of 101 and 3600 m from the storage tank, respectively. This study is expected to play an important role for decision‐makers in preventing benzene‐related accident risks and to reducing loss.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Accident consequence assessment of benzene leakage from storage tank in a chemical park in Bengbu City, China

Zhou

Chen²,

et al. 2023

Process Safety Progress

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“…In the organicaqueous bilayer extraction procedures, we adopted the Chem Elut cartridge, which economically and effectively supported liquid-liquid extraction. Regarding the selection of the sample-solving medium, we previously reported the trace analysis of residual benzene in the delgocitinib drug substance using liquid-liquid extraction and conventional high-performance liquid chromatography (HPLC); and hence, we recommended potassium hydroxide and a hydrochloric acid solution as the sample-solving medium, as most marketed drug substances are soluble in them [22]. However, because MMS, EMS, and IPMS are hydrolyzed under the acidic or basic condition, we focused on ionic liquids that can solubilize complex polar molecules [23,24].…”

Section: Introductionmentioning

confidence: 99%

Development of trace analysis for alkyl methanesulfonates in the delgocitinib drug substance using GC-FID and liquid–liquid extraction with ionic liquid

et al. 2020

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Alkyl methanesulfonates are genotoxic impurities that should be limited to an intake of not more than 1.5 µg/day, as regulated by the International Council for Harmonization guideline M7. We herein report a trace analysis of methyl methanesulfonate (MMS), ethyl methanesulfonate (EMS), and isopropyl methanesulfonate (IPMS) in the delgocitinib drug substance using liquid–liquid extraction, with an ionic liquid as the sample-solving medium, and direct injection gas chromatography detected with a flame-ionization detector. The proposed method takes advantage of the fine solubility of ionic liquids toward the drug substance, the good extraction efficiency of alkyl methanesulfonates in liquid–liquid extraction using the Chem Elut cartridge with low-polar organic solvents, and the ability of alkyl methanesulfonates to concentrate in minimum amounts of organic solvent, resulting in excellent sensitivity and selectivity. Specifically, for the preparation of the sample solution, a mixture of 1-butyl-3-methylimidazolium chloride, water, and acetonitrile was used as the sample-solving media, extracted with diethyl ether, and the eluent was concentrated to 1 mL. The method showed good linearity, accuracy, and precision from 1 to 5 ppm, and the limits of detection of MMS, EMS, and IPMS were 0.1, 0.05, and 0.05 ppm, respectively.

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Biomedical applications of Janus membrane

Qian

Zhao

Mao

et al. 2023

Biomedical Technology

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Development and validation of an assay method for benzene in the delgocitinib drug substance using conventional HPLC

Cited by 3 publications

References 11 publications

Accident consequence assessment of benzene leakage from storage tank in a chemical park in Bengbu City, China

Accident consequence assessment of benzene leakage from storage tank in a chemical park in Bengbu City, China

Development of trace analysis for alkyl methanesulfonates in the delgocitinib drug substance using GC-FID and liquid–liquid extraction with ionic liquid

Biomedical applications of Janus membrane

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