Biomedical applications of Janus membrane

Qian, Shutong; Zhao, Binfan; Mao, Jiayi; Liu, Zhimo; Zhao, Qing; Lu, Bolun; Mao, Xiyuan; Zhang, Liucheng; Cheng, Liying; Zhang, Yuguang; Cui, Wenguo; Sun, Xiaoming

doi:10.1016/j.bmt.2022.11.003

Cited by 22 publications

(14 citation statements)

References 102 publications

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“…The doped sample depicts an enhanced surface charge of the microsphere and forms a homogeneous solution, which is suitable for any biological application. As previously reported, the hydrophilic types of wound dressing materials are suitable for fast wound healing . However, our synthesized HMMS@GSNP microsphere is a suitable healing material for infected wounds.…”

Section: Discussionmentioning

confidence: 64%

Fabrication and Therapeutic Process of a Green Silver-Nanoparticle-Embedded Mucilage Microsphere for Pathogenic-Bacteria-Infected Second-Degree Burn and Excision Wounds

Saha,

Ghosh,

Mondal

et al. 2024

ACS Appl. Bio Mater.

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Multidrug-resistant bacteria are a serious problem in biomedical applications that decrease the wound healing process and increase the mortality rate. Therefore, in this study, we have prepared a green-synthesized silvernanoparticle-encapsulated mucilage microsphere (HMMS@GSNP) from Hibiscus rosa sinensis leaves and applied it to pathogen-infected burn and excision wounds. Biophysical properties like size, polydispersity index, absorbance capacity, and drug release were measured by different techniques like field-emission scanning electron microscopy, dynamic light scattering, swelling ratio, etc. The strong antibacterial activity of a HMMS@GSNP microsphere was measured by minimum inhibitory concentration assay, minimum bactericidal concentration assay, and agar well diffusion methods. The HMMS@GSNP microsphere enhanced the cell viability, cell proliferation, migration, antioxidant, and antiinflammation activity compared to untreated GSNP and HMMS, as quantified by MTT assay, BrdU assay, scratch wound assay, reactive oxygen species scavenging assay, and Western blot analysis, respectively. In the in vivo experiment, we used a methicillin-resistant Staphylococcus aureus bacteria-infected, burn-and-excision-wound-created male BALB/c mice model. The HMMS@GSNP-treated burn-and-excision-wound-infected mice showed significant results compared to other groups (untreated, Silverex Ionic Gel, AgNO 3 , HMMS, and GSNP), and the mice tissues were utilized for bacteria count, immunoblot analysis, histological studies, and real-time polymerase chain reaction. Thus, the HMM@GSNP microsphere is an excellent therapeutic material that can be used as a topical agent for the management of chronic wound therapy.

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Section: Discussionmentioning

confidence: 64%

Fabrication and Therapeutic Process of a Green Silver-Nanoparticle-Embedded Mucilage Microsphere for Pathogenic-Bacteria-Infected Second-Degree Burn and Excision Wounds

Saha,

Ghosh,

Mondal

et al. 2024

ACS Appl. Bio Mater.

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“…the juxtaposition of lyophobic and lyophilic layers whose wettability contrast enables directional fluid transport from the first to the second layer, preventing flow in the opposite direction (Wang et al 2010;Wu et al 2012). The above-mentioned asymmetry can involve either geometrical and/or chemico-physical properties of the membrane surface corresponding to a different fabrication strategy (see Qian et al 2023 for a review). Membrane-based wound dressings with asymmetric properties are exploited to facilitate water evaporation, thus creating a dry environment, and promote hair follicle regeneration in burnt skin (de Groot et al 2021).…”

Section: Introductionmentioning

confidence: 99%

“…The above-mentioned asymmetry can involve either geometrical and/or chemico-physical properties of the membrane surface corresponding to a different fabrication strategy (see Qian et al. 2023 for a review). Membrane-based wound dressings with asymmetric properties are exploited to facilitate water evaporation, thus creating a dry environment, and promote hair follicle regeneration in burnt skin (de Groot et al.…”

Section: Introductionmentioning

confidence: 99%

Homogenization theory captures macroscopic flow discontinuities across Janus membranes

Zampogna,

Ledda,

Wittkowski

et al. 2023

J. Fluid Mech.

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Janus membranes, thin permeable structures with chemical and geometrical asymmetric properties, show great potential in industrial separation processes. Yet the link between the micro- and macro-scale behaviours of these membranes needs to be established rigorously. Here, we develop interface conditions to describe the solvent–solute flow across Janus membranes within a homogenization-based framework. Upstream and downstream spatial averages are introduced to account for discontinuities induced by the microstructure. The homogenized model quantifies the macroscopic jump, across the membrane, in the solvent velocity and stresses, and in the solute concentration and fluxes through coefficients obtained via closure problems at the micro-scale. The model paves the way towards a better understanding of fundamental interface phenomena such as osmosis and phoresis via homogenization.

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“…This amalgamation of functionalities in bipolymer nanofibers not only addresses the limitations of individual materials but also opens doors to transformative advancements across various applications, underscoring the urgency of developing multifunctional materials to meet the diverse demands of the modern era. 6 Bifunctional materials, even when sharing the same composition, can exhibit distinct functional properties due to variations in their structural arrangement. This divergence in properties consequently determines the scope of applications for materials of differing structures.…”

Section: Introductionmentioning

confidence: 99%

“…Simultaneously, the hydrophobic portion can serve as a barrier, preventing the unwanted passage of substances, crucial for controlled drug release systems. This amalgamation of functionalities in bipolymer nanofibers not only addresses the limitations of individual materials but also opens doors to transformative advancements across various applications, underscoring the urgency of developing multifunctional materials to meet the diverse demands of the modern era 6 …”

Section: Introductionmentioning

confidence: 99%

Bipolymer nanofibers: Engineering nanoscale interface via bubble electrospinning

Ali,

2023

J of Applied Polymer Sci

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Modern applications in biomedicine, drug delivery, and tissue engineering demand versatile materials capable of meeting multifaceted requirements. Conventional mono‐functional materials fall short of addressing these complex demands. To tackle this challenge, this study introduces an innovative approach utilizing bubble electrospinning for the fabrication of bipolymeric side‐by‐side nanofibers. These nanofibers incorporate distinct hydrophilic and hydrophobic domains aligned parallel to their axis, achieved through the electrospinning of polyvinyl alcohol (PVA) as the hydrophilic component, alongside either poly(ε‐caprolactone) (PCL) or Nylon6 as the hydrophobic component. The optimal diameter of the bubble electrospinning reservoir was theoretically determined via simulation of electric field using Maxwell 3D software and experimentally validated. Successful electrospinning resulted in nanofibers with hydrophilic and hydrophobic domains derived from PVA/Nylon6 and PVA/PCL polymer combinations. This innovative process yielded nanofibers with diameters as fine as 101 nm in the PVA/Nylon6 bipolymeric nanofibers. Transmission electron microscopy images provide compelling insights into the distinct interfaces formed during polymer‐polymer interactions within the nanofibers, manifesting the Janus structure. Furthermore, Fourier‐transform infrared spectroscopy confirms the presence of both polymers within the nanofiber matrix. This research represents a significant advancement in the efficient production of bipolymer nanofibers, holding promise for a wide range of applications.

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Biomedical applications of Janus membrane

Cited by 22 publications

References 102 publications

Fabrication and Therapeutic Process of a Green Silver-Nanoparticle-Embedded Mucilage Microsphere for Pathogenic-Bacteria-Infected Second-Degree Burn and Excision Wounds

Fabrication and Therapeutic Process of a Green Silver-Nanoparticle-Embedded Mucilage Microsphere for Pathogenic-Bacteria-Infected Second-Degree Burn and Excision Wounds

Homogenization theory captures macroscopic flow discontinuities across Janus membranes

Bipolymer nanofibers: Engineering nanoscale interface via bubble electrospinning

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