“…Currently, there is a lack of appropriate methods to determine plasma concentrations for the wide variety of clinically used oral anticancer drugs. Existing methods are limited to the quantification of only a few oral anticancer drugs simultaneously, with a maximum of 17 published [ 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 ]. Each of these methods requires an individual analytical setup, which makes them suitable for a limited number of drugs only and therefore hampers the use in studies or clinical situations with a wide range of oral anticancer drugs.…”