Development and validation of a risk score using complete blood count to predict in-hospital mortality in COVID-19 patients

Liu, Hui; Yang, Qin; Lei, Fang; Zhang, Changjiang; Qin, Juan Juan; Chen, Ze; Zhu, Lihua; Song, Xiaohui; Bai, Lei; Huang, Xuewei; Liu, Weifang; Zhou, Feng; Chen, Ming Ming; Zhao, Yan; Zhang, Xiao Jing; She, Zhi Gang; Xu, Qingbo; Ma, Xin‐Liang; Zhang, Peng; Ji, Yan; Zhang, Xin; Yang, Juan; Xie, Jing; Azzolini, Elena; Aghemo, Alessio; Ciccarelli, Michele; Condorelli, Gianluigi; Xia, Jiahong; Zhang, Bing Hong; Yuan, Yufeng; Xiang, Wei; Wang, Yibin; Cai, Jingjing; Li, Hongliang

doi:10.1016/j.medj.2020.12.013

Cited by 24 publications

(26 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The inflammatory response can stimulate the production of inflammatory cells and accelerate the apoptosis of lymphocytes (20). COVID-19 Patients with lymphopenia experience a significantly lower risk of death (21).The neutrophil to lymphocyte ratio is an independent risk factor for the death of COVID-19 patients at hospitals (22).Therefore, the inflammatory parameters in the early stages of the disease should be carefully attended. The number of white blood cellscould be quickly revealedby a routine inpatient blood test, which greatly helpsto identify high-risk COVID-19 patients in the early stages.…”

Section: Resultsmentioning

confidence: 99%

Effects of Clinical Symptoms and Laboratory Values of COVID- 19 Patients' Tests at the Time of Hospitalization on Their Clinical Outcomes

Shahverdi¹,

Hemmat²,

Islamy³

2021

PJMHS

View full text Add to dashboard Cite

Introduction: At the end of 2019, a new coronavirus caused pneumonia in Wuhan, China. Several studies have described the clinical features and immune manifestations in COVID-19 patients with moderate to severe symptoms, while their clinical relevance is less clear. This study investigates the effects of clinical symptoms and laboratory values of COVID-19 patients' tests at the time of hospitalization on their clinical outcomes. Methodology: This descriptive cross-sectional study was performed on COVID-19 patients hospitalized in Arak hospitals from April 2020 to March 2020. Medical records of all the hospitalized patients were retrieved. Trained personnel extracted general information (age and gender) and clinical profiles (the complete blood count and other required tests). Findings: Analyzing the laboratory indices of the blood count and LDH and CPK levels revealed a positive relationship between the patients' serum CPK levels, and the mortality rate (P = 0.001) and length of hospitalization (P = 0.015). Conclusion: The patients' serum LDH levels and fever were also associated with the mortality rate, and the need for mechanical ventilation, respectively. We hope this information helps physicians treat COVID-19 patients. Keywords: COVID-19, clinical symptoms, laboratory tests

show abstract

Section: Resultsmentioning

confidence: 99%

Effects of Clinical Symptoms and Laboratory Values of COVID- 19 Patients' Tests at the Time of Hospitalization on Their Clinical Outcomes

Shahverdi¹,

Hemmat²,

Islamy³

2021

PJMHS

View full text Add to dashboard Cite

show abstract

“…However, weighing each of these findings separately as a better predictor of the disease outcome proves to be very complicated. In this context, different scores that group several of these variables and assign a weight to them have emerged continuously up to the present time [ 25 , 26 , 27 ] as well as alternatives to conventional diagnostic tests, such as lung ultrasound [ 28 ]. However, a new question arises when trying to use these indices in clinical practice, where effectiveness in the management of time and resources is essential in a pandemic context.…”

Section: Discussionmentioning

confidence: 99%

Lung Ultrasound, Clinical and Analytic Scoring Systems as Prognostic Tools in SARS-CoV-2 Pneumonia: A Validating Cohort

et al. 2021

View full text Add to dashboard Cite

At the moment, several COVID-19 scoring systems have been developed. It is necessary to determine which one better predicts a poor outcome of the disease. We conducted a single-center prospective cohort study to validate four COVID-19 prognosis scores in adult patients with confirmed infection at ward. These are National Early Warning Score (NEWS) 2, Lung Ultrasound Score (LUS), COVID-19 Worsening Score (COWS), and Spanish Society of Infectious Diseases and Clinical Microbiology score (SEIMC Score). Our outcomes were the combined variable “poor outcome” (non-invasive mechanical ventilation, intubation, intensive care unit admission, and death at 28 days) and death at 28 days. Scores were analysed using univariate logistic regression models, receiver operating characteristic curves, and areas under the curve. Eighty-one patients were included, from which 21 had a poor outcome, and 9 died. We found a statistically significant correlation between poor outcome and NEWS2, LUS > 15, and COWS. Death at 28 days was statistically correlated with NEWS2 and SEIMC Score although COWS also performs well. NEWS2, LUS, and COWS accurately predict poor outcome; and NEWS2, SEIMC Score, and COWS are useful for anticipating death at 28 days. Lung ultrasound is a diagnostic tool that should be included in COVID-19 patients evaluation.

show abstract

“…Os neutrófilos apresentam-se aumentados em pacientes com COVID-19 em relação aos pacientes sem a doença (ESLAMIJOUYBARI et al, 2020;SAYED et al, 2021). Em 11 estudos de 12 que compararam pacientes graves com casos leves, observou que indivíduos com casos graves de COVID-19 tiveram um aumento nos níveis de neutrófilos em relação a casos leves (BELLAN et al, 2021;GALLAND et al, 2021;GEROTZIAFAS et al, 2020;KILERCIK et al, 2021;LANINI et al, 2020;LINSSEN et al, 2020;ZHANG et al, 2020;LIU et al, 2021;OZBALAK et al, 2021;PAKOS et al, 2020;SAYAH et al, 2021).…”

Section: Leucogramaunclassified

“…As plaquetas apresentaram resultados significativos com níveis mais baixos de pacientes com COVID-19 em relação aos pacientes sem a doença (ESLAMIJOUYBARI et al, 2020;SAYED et al, 2021;SEYIT et al, 2021). Em todos os estudos analisados (n= 6) que compararam pacientes graves com casos leves, observou que indivíduos com casos graves de COVID-19 tiveram uma diminuição nos níveis de plaquetas em relação a casos leves (BELLAN et al, 2021;FOY et al, 2020;LANINI et al, 2020;LIU et al, 2021;PAKOS et al, 2020;RAHMAN et al, 2021). O mecanismo para trombocitopenia é multifatorial em casos respiratórios agudos graves e refere-se a uma combinação de infecção viral e ventilação mecânica levando a dano endotelial desencadeando ativação, agregação e trombose plaquetária no pulmão, causando grande consumo de plaquetas (ESLAMIJOUYBARI et al, 2020).…”

Section: Plaquetogramaunclassified

Principais Alterações Do Hemograma Potencialmente Associadas Ao Covid-19

Rohde¹,

Montagner²,

Oviedo³

et al. 2021

Anais Do XXV Simpósio De Ensino, Pesquisa E Extensão, Edição 2021

View full text Add to dashboard Cite

Development and validation of a risk score using complete blood count to predict in-hospital mortality in COVID-19 patients

Cited by 24 publications

References 33 publications

Effects of Clinical Symptoms and Laboratory Values of COVID- 19 Patients' Tests at the Time of Hospitalization on Their Clinical Outcomes

Effects of Clinical Symptoms and Laboratory Values of COVID- 19 Patients' Tests at the Time of Hospitalization on Their Clinical Outcomes

Lung Ultrasound, Clinical and Analytic Scoring Systems as Prognostic Tools in SARS-CoV-2 Pneumonia: A Validating Cohort

Principais Alterações Do Hemograma Potencialmente Associadas Ao Covid-19

Contact Info

Product

Resources

About