Development and Validation of a Complete GATE Model of the Siemens Inveon Trimodal Imaging Platform

Lee, Sanghyeb; Gregor, Jens; Osborne, Dustin

doi:10.2310/7290.2013.00058

Cited by 30 publications

(25 citation statements)

References 15 publications

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“…It has been extensively validated and used in numerous projects to evaluate new PET scanner designs. [48][49][50][51][52][53][54][55][56][57][58][59][60][61][62][63] Without simulations, it is very challenging to explore new scanner designs, due to the cost and complexity of creating prototype systems intended solely for design evaluation purposes. AnnPET was modeled using the C-PET GATE scanner definition with a 6 ns coincidence timing window and 15% energy resolution; positron transport, Compton scattering, and photoelectric interactions were included in the model.…”

Section: Detector Geometry Definitionmentioning

confidence: 99%

Preclinical positron emission tomography scanner based on a monolithic annulus of scintillator: initial design study

et al. 2017

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Abstract. Positron emission tomography (PET) scanners designed for imaging of small animals have transformed translational research by reducing the necessity to invasively monitor physiology and disease progression. Virtually all of these scanners are based on the use of pixelated detector modules arranged in rings. This design, while generally successful, has some limitations. Specifically, use of discrete detector modules to construct PET scanners reduces detection sensitivity and can introduce artifacts in reconstructed images, requiring the use of correction methods. To address these challenges, and facilitate measurement of photon depth-ofinteraction in the detector, we investigated a small animal PET scanner (called AnnPET) based on a monolithic annulus of scintillator. The scanner was created by placing 12 flat facets around the outer surface of the scintillator to accommodate placement of silicon photomultiplier arrays. Its performance characteristics were explored using Monte Carlo simulations and sections of the NEMA NU4-2008 protocol. Results from this study revealed that AnnPET's reconstructed spatial resolution is predicted to be ∼1 mm full width at half maximum in the radial, tangential, and axial directions. Peak detection sensitivity is predicted to be 10.1%. Images of simulated phantoms (mini-hot rod and mouse whole body) yielded promising results, indicating the potential of this system for enhancing PET imaging of small animals.

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Section: Detector Geometry Definitionmentioning

confidence: 99%

Preclinical positron emission tomography scanner based on a monolithic annulus of scintillator: initial design study

et al. 2017

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“…The primary issue would be to develop a method by which the gammas emitted from 125 I could be separated from any CT X-rays. One approach would be to use a Monte Carlo model that would enable a statistical method of removing the X-rays from the 125 I SPECT projection data, such as the GATE model created for this platform by Lee et al [17, 18]. …”

Section: Discussionmentioning

confidence: 99%

Feasibility and Initial Performance of Simultaneous SPECT-CT Imaging Using a Commercial Multi-Modality Preclinical Imaging System

Osborne

Austin

2015

International Journal of Molecular Imaging

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Multi-modality imaging provides coregistered PET-CT and SPECT-CT images; however such multi-modality workflows usually consist of sequential scans from the individual imaging components for each modality. This typical workflow may result in long scan times limiting throughput of the imaging system. Conversely, acquiring multi-modality data simultaneously may improve correlation and registration of images, improve temporal alignment of the acquired data, increase imaging throughput, and benefit the scanned subject by minimizing time under anesthetic. In this work, we demonstrate the feasibility and procedure for modifying a commercially available preclinical SPECT-CT platform to enable simultaneous SPECT-CT acquisition. We also evaluate the performance of simultaneous SPECT-CT tomographic imaging with this modified system. Performance was accessed using a 57Co source and image quality was evaluated with 99mTc phantoms in a series of simultaneous SPECT-CT scans.

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“…We could expect some scatter estimation techniques may be needed to deal with the increased inter-crystal scattering. We would prefer simple methods based on Klein-Nishina formula [9] or scattering kernels [10] than the Monte-Carlo simulations [11], because the latter are computationally much more expensive.…”

Section: Discussionmentioning

confidence: 99%

Modeling of Pixelated Detector in SPECT Pinhole Reconstruction

Feng

Zeng

2014

IEEE Trans. Nucl. Sci.

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A challenge for the pixelated detector is that the detector response of a gamma-ray photon varies with the incident angle and the incident location within a crystal. The normalization map obtained by measuring the flood of a point-source at a large distance can lead to artifacts in reconstructed images. In this work, we investigated a method of generating normalization maps by ray-tracing through the pixelated detector based on the imaging geometry and the photo-peak energy for the specific isotope. The normalization is defined for each pinhole as the normalized detector response for a point-source placed at the focal point of the pinhole. Ray-tracing is used to generate the ideal flood image for a point-source. Each crystal pitch area on the back of the detector is divided into 60 × 60 sub-pixels. Lines are obtained by connecting between a point-source and the centers of sub-pixels inside each crystal pitch area. For each line ray-tracing starts from the entrance point at the detector face and ends at the center of a sub-pixel on the back of the detector. Only the attenuation by NaI(Tl) crystals along each ray is assumed to contribute directly to the flood image. The attenuation by the silica (SiO2) reflector is also included in the ray-tracing. To calculate the normalization for a pinhole, we need to calculate the ideal flood for a point-source at 360 mm distance (where the point-source was placed for the regular flood measurement) and the ideal flood image for the point-source at the pinhole focal point, together with the flood measurement at 360 mm distance. The normalizations are incorporated in the iterative OSEM reconstruction as a component of the projection matrix. Applications to single-pinhole and multi-pinhole imaging showed that this method greatly reduced the reconstruction artifacts.

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Development and Validation of a Complete GATE Model of the Siemens Inveon Trimodal Imaging Platform

Cited by 30 publications

References 15 publications

Preclinical positron emission tomography scanner based on a monolithic annulus of scintillator: initial design study

Preclinical positron emission tomography scanner based on a monolithic annulus of scintillator: initial design study

Feasibility and Initial Performance of Simultaneous SPECT-CT Imaging Using a Commercial Multi-Modality Preclinical Imaging System

Modeling of Pixelated Detector in SPECT Pinhole Reconstruction

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