“…1 A survey of the literature showed a few methods of MEL determination. They include spectrophotometry, 2 densitometry, 3 HPLC-UV, 4,5 GC-MS 6 and LC-MS. [7][8][9] Most of these techniques require highly skilled laboratory staff and expensive equipment. In this sense, the development of reliable, low cost and a simple analytical method for MEL determination in various formulations and biological fluids is still needed in the field of the drug quality control and clinical analysis.…”