Development and Validation of a Spectrophotometric Method for Quantification and Dissolution Studies of Glimepiride in Tablets

Abstract

The objective of present study was to develop and validate an analytical method for quantitative determination and dissolution studies of glimepiride in tablets. The glimepiride shows absorption maxima at 225 nm and obeyed Beer's law in the range of 6.0 – 14.0 µg/mL. The limit of detection and limit of quantitation were 0.06, and 0.17 µg/mL respectively. Percentage recovery of glimepiride for the proposed method ranged from 99.32 to 100.98% indicating no interference of the tablet excipients. It was concluded that the proposed method is simple, easy to apply, economical and used as an alternative to the existing spectrophotometric and non-spectrophotometric methods for the routine analysis of glimepiride in pharmaceutical formulations andin vitrodissolution studies.

Formulation and Characterization of Blend Microspheres of Anti Diabetic Drug Glimepiride

“…The absorption maxima was obtained to be 224.0 nm and was used to measuring the absorbance of glimepiride in solutions throughout the study. In previous studies the absorption maxima have been reported to be 225 nm 50 , 228 nm 57 and 236 nm 58 .…”

Preparation and evaluation of naproxen ternary solid dispersion using genetically modified cassava starch and hydroxypropyl methyl cellulose

“…The hardness of the tablets was respectively 5.1 and 7 kg/cm 3 for T2 and TN. The evaluation of tablet hardness is important to assess the integrity of tablets during storage and transportation (Induri et al, 2012). Hardness affects other tablet properties like disintegration as tablets that are too hard may have delayed disintegration time (Pisek et al, 2002).…”

Development and validation of a dissolution test for lodenafil carbonate based onin vivodata

“…Although dissolution appears to be a simple process, developing a suitable dissolution test for the drug content of solid dosage forms is not a trivial task, especially considering that dissolution testing is a critical step in quality control for manufactured final products and it is one of the standard methods for assessing batch-to-batch consistency of solid oral drug delivery systems 1,2 . Dissolution test is used not only for quality control of the final dosage form, but also to assess several stages of formulation [3][4][5] . Therefore, when in vitro-in vivo correlation (IVIVC) is established, prediction of in vivo profile can be done based on in vitro dissolution profile 6,7 .…”