Development and Validation of a Prognostic Prediction Model for Postoperative Ovarian Sex Cord-Stromal Tumor Patients

You, Danming; Zhang, Zuyu; Cao, Mei

doi:10.12659/msm.925844

Cited by 7 publications

(8 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The internal validation confirmed that the nomogram was highly accurate in predicting premature death and helpful in screening patients with high clinical risk with high practicality [18]. You et al [19] included 506 eligible patients with postoperative ovarian sex cord-stromal tumor (SCST) from the SEER database. They constructed and validated the OS nomogram, which showed that it was more practical than FIGO staging [19].…”

Section: Discussionmentioning

confidence: 91%

See 1 more Smart Citation

A prognostic model of patients with ovarian mucinous adenocarcinoma: a population-based analysis

Yang

Zhang

et al. 2022

J Ovarian Res

View full text Add to dashboard Cite

Background Ovarian mucinous carcinoma is a disease that requires unique treatment. But for a long time, guidelines for ovarian serous carcinoma have been used for the treatment of ovarian mucinous carcinoma. This study aimed to construct and validate nomograms for predicting the overall survival (OS) and cancer-specific survival (CSS) in patients with ovarian mucinous adenocarcinoma. Methods In this study, patients initially diagnosed with ovarian mucinous adenocarcinoma from 2004 to 2015 were screened from the Surveillance, Epidemiology, and End Results (SEER) database, and divided into the training group and the validation group at a ratio of 7:3. Independent risk factors for OS and CSS were determined by multivariate Cox regression analysis, and nomograms were constructed and validated. Results In this study, 1309 patients with ovarian mucinous adenocarcinoma were finally screened and randomly divided into 917 cases in the training group and 392 cases in the validation group according to a 7:3 ratio. Multivariate Cox regression analysis showed that the independent risk factors of OS were age, race, T_stage, N_stage, M_stage, grade, CA125, and chemotherapy. Independent risk factors of CSS were age, race, marital, T_stage, N_stage, M_stage, grade, CA125, and chemotherapy. According to the above results, the nomograms of OS and CSS in ovarian mucinous adenocarcinoma were constructed. In the training group, the C-index of the OS nomogram was 0.845 (95% CI: 0.821–0.869) and the C-index of the CSS nomogram was 0.862 (95%CI: 0.838–0.886). In the validation group, the C-index of the OS nomogram was 0.843 (95% CI: 0.810–0.876) and the C-index of the CSS nomogram was 0.841 (95%CI: 0.806–0.876). The calibration curve showed the consistency between the predicted results and the actual results, indicating the high accuracy of the nomogram. Conclusion The nomogram provides 3-year and 5-year OS and CSS predictions for patients with ovarian mucinous adenocarcinoma, which helps clinicians predict the prognosis of patients and formulate appropriate treatment plans.

show abstract

Section: Discussionmentioning

confidence: 91%

“…You et al [19] included 506 eligible patients with postoperative ovarian sex cord-stromal tumor (SCST) from the SEER database. They constructed and validated the OS nomogram, which showed that it was more practical than FIGO staging [19].…”

Section: Discussionmentioning

confidence: 99%

A prognostic model of patients with ovarian mucinous adenocarcinoma: a population-based analysis

Yang

Zhang

et al. 2022

J Ovarian Res

View full text Add to dashboard Cite

show abstract

“…Marital status was found to be an independent prognostic factor in patients with ovarian sex cordstromal cancer [18] and gastric adenocarcinoma [19]. Assessment of the relationship between marital status and OS in patients with mGC who underwent surgery found, however, that marital status was not associated with OS.…”

Section: Discussionmentioning

confidence: 94%

Development and Validation of a Prognostic Nomogram for Predicting the Overall Survival of Patients with Metastatic Gastric Cancer who Undergo Surgery

Guan

Sun

Pan

et al. 2022

Preprint

View full text Add to dashboard Cite

Background The benefits of surgery in patients with metastatic gastric cancer remain unclear. A nomogram may predict overall survival (OS) time of patients with metastatic gastric cancer who undergo surgery. Methods The development set consisted of 1300 patients from the Surveillance, Epidemiology, and End Results Program who were diagnosed with metastatic gastric cancer and underwent surgery in 2004–2015, whereas the validation set consisted of 555 patients diagnosed in 2004–2015. Variables were incorporated into a Cox proportional hazards model to identify independent risk factors for survival. Nomograms predicting 1-, 2-, and 3-year OS probabilities were designed using the development dataset. Receiver operating characteristic (ROC) curves and calibration curves were plotted to determine the accuracy of the nomograms. The net benefit of prediction models was evaluated using decision curve analysis (DCA). Results Age, primary tumor site, T stage, and N stage were risk factors for OS, whereas chemotherapy and radiotherapy were protective factors of OS. A nomogram including all of these variables had areas under the ROC curves (AUC) predicting 1-, 2-, and 3-year OS of 0.684, 0.676, and 0.685, respectively, for the development dataset and 0.689, 0.642, and 0.665, respectively, for the validation dataset. A calibration curve showed that the OS probability predicted by the nomogram was in good agreement with the actual OS probability. The DCA curves suggested that the nomogram provides a superior net benefit. Conclusions This nomogram can help predict the OS of patients with metastatic gastric cancer who underwent surgery. This nomogram can help clinicians make correct clinical decisions to prolong the OS of these patients.

show abstract

“…Analysis stratified by stage found that stages IA and IB patients who received chemotherapy had poor OS, while OS showed no significant difference in patients with other stages. 72 This deleterious effect of chemotherapy may be due to ineffective chemotherapeutic regimens, side effects, and individual differences in patients’ tolerance to chemotherapy. The unfavorable results of chemotherapy indicate the need for further exploration.…”

Section: Chemotherapymentioning

confidence: 99%

Oncological Prognosis and Fertility Outcomes of Different Surgical Extents for Malignant Ovarian Sex-Cord Stromal Tumors: A Narrative Review

J¹,

Jiang²

2022

CMAR

View full text Add to dashboard Cite

Background Malignant ovarian sex-cord stromal tumors (MOSCSTs) are rare neoplasms that account for approximately 5–7% of all ovarian malignancies. The majority (70%) of patients had an early stage; thus, surgery is the predominant treatment. Patients were relatively young at the onset of the tumor. Moreover, the prognosis of patients with this tumor is better than that of malignant epithelial ovarian tumors and tends to recur late with an indolent clinical course. Thus, patients may be more inclined to conservative surgical procedures. There is, however, no objective criterion for selecting a suitable surgical procedure. Clinically, surgical extent depended on the preoperative evaluations, age, and willingness of patients, and gynecologists were relatively subjective when choosing surgery. The prognosis of patients with different surgical extents is still controversial. The review aimed to summarize the impacts of different surgical extents on oncological prognosis and fertility outcomes. Methods The literature search was performed in PubMed ( https://www.ncbi.nlm.nih.gov/pubmed/ ), and publications between January 2011 and December 2021 in English including clinical cohort studies and case reports were eligible for inclusion. Results We finally identified 12 large-sample retrospective studies and 18 cases of MOSCSTs. The primary surgical procedures include fertility-spring surgery (FSS), total hysterectomy with unilateral or bilateral salpingo-oophorectomy (TAH-USO/BSO), FSS with complete staging procedure, complete staging surgery (CSS), and debulking surgery. FSS includes cystectomy (CYS), unilateral salpingo-oophorectomy (USO) or bilateral salpingo-oophorectomy (BSO) with uterine preservation that allows for potential future assisted reproductive approaches. Complete staging procedure includes peritoneal cytologic examinations, inspections of peritoneal surfaces, random peritoneal biopsies and omentectomy. FSS with complete staging procedure means surgical procedure with uterine preservation and complete staging procedure. And, generally, CSS means TAH-BSO with complete staging procedure. Conclusion It can be concluded that USO can be done in young, fertility-desired patients with tumors confined to the ovary but avoid CYS. FSS with complete staging procedure is feasible among stage IC-III patients who have fertility desire. Patients can choose to have a complete surgery once their family is complete or without fertility requirements. CSS is recommended for patients with risk factors such as high stage, poor differentiation, and large tumor size and without fertility desire. A close follow-up is essential.

show abstract

Development and Validation of a Prognostic Prediction Model for Postoperative Ovarian Sex Cord-Stromal Tumor Patients

Cited by 7 publications

References 35 publications

A prognostic model of patients with ovarian mucinous adenocarcinoma: a population-based analysis

A prognostic model of patients with ovarian mucinous adenocarcinoma: a population-based analysis

Development and Validation of a Prognostic Nomogram for Predicting the Overall Survival of Patients with Metastatic Gastric Cancer who Undergo Surgery

Oncological Prognosis and Fertility Outcomes of Different Surgical Extents for Malignant Ovarian Sex-Cord Stromal Tumors: A Narrative Review

Contact Info

Product

Resources

About