Development and testing of an absorbable spring for cranial expansion in rabbits

In vitro evaluation of poly (lactic‐co‐glycolic acid)/polyisoprene fibers for soft tissue engineering

“…76 As previously stated, in vivo applications of PLGA/PI blend have been related to the formation of intensively vascularised areas in bone tissue reconstruction. 34,35 This effect is strongly related to the presence of Poly(Isoprene) in the grafts, as previously observed in other applications. [77][78][79] This may indicate another desirable characteristic of this polymeric blend for dermal tissue engineering.…”

“…For that to be achieved, the use of angiogenic factors is essential in order to guarantee fast vascularisation on the treated area . As previously stated, in vivo applications of PLGA/PI blend have been related to the formation of intensively vascularised areas in bone tissue reconstruction . This effect is strongly related to the presence of Poly(Isoprene) in the grafts, as previously observed in other applications .…”

“…The idea of replacing the metallic springs with polymeric springs seeks the application of a material that will be better tolerated and posteriorly absorbed by the body, avoiding the need of a second surgical procedure to extract the device . Evaluating the cranial response in rats (Wistar) and rabbits (New Zealand), the springs made of PLGA/PI showed proper expansion of interbone space, biocompatibility with the bone environment and neovascularisation of areas surrounding the device …”

“…33 Evaluating the cranial response in rats (Wistar) and rabbits (New Zealand), the springs made of PLGA/PI showed proper expansion of interbone space, biocompatibility with the bone environment and neovascularisation of areas surrounding the device. 34,35 From the positive results presented in other biomedical applications comes the possibility of applying Cellprene TM in tissue engineering, acquiring a deeper knowledge about this material by exploring a new processing technique while attending to the most fundamental demands of TE scaffolds. Its mechanical properties may suggest this material to be more reliable as a scaffold for reconstruction of soft tissues, such as muscle, cartilage and skin.…”

Histological and structural evaluation of growth hormone and PLGA incorporation in macroporous scaffold of α-tricalcium phosphate cement

“…Studies have shown that the combination of the two materials increases the mechanical strength of the polymer when compared to PLGA fibers alone and has been used successfully. 8,10,11 However, the addition of spherical microparticles to CaP, despite increasing its macroporosity, does not allow a pattern of channels and interconnectivity between the pores, necessary for better tissue penetration and new bone formation. 12 Studies have incorporated resorbable polymer fibers, such as polyglactin, 13 poly(epsilon-caprolactone) and polylactic acid, 5 with the aim of increasing the mechanical resistance and the amount of interconnected macropores, which are important characteristics when it is used in medical and dental reconstructions, in mechanical stress places, in large bone reconstructions and sites of thin and delicate bone structure.…”