Development and Optimization of Insulin-Chitosan Nanoparticles

Zhao, Liang; Su, Chang; Zhu, Bingya; Jia, Yunhong

doi:10.4314/tjpr.v13i1.1

Cited by 12 publications

(6 citation statements)

References 15 publications

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“…Studies [25,26] have indicated that RSM is an outstanding and effective statistical technique for complex optimization processes by reducing the number of experimental trials compared with traditional methods. Thus, it is widely used to optimize the extraction process of polysaccharides [27].…”

Section: Discussionmentioning

confidence: 99%

Extraction optimization and characterization of polysaccharide antioxidants from <i>Pinellia ternata</i> (Thunb) Breit rhizome

Mo¹,

Liu²,

Tao³

et al. 2017

Trop. J. Pharm Res

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Section: Discussionmentioning

confidence: 99%

Extraction optimization and characterization of polysaccharide antioxidants from <i>Pinellia ternata</i> (Thunb) Breit rhizome

Mo¹,

Liu²,

Tao³

et al. 2017

Trop. J. Pharm Res

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“…(NaOH) (Hecq et al, 2015;Li et al, 2017), or insulin can even be directly solubilized into diluted NaOH, or directly into TPP solution (Zhao et al, 2014). Then, the insulin solution is added to the chitosan solution right before or during TPP addition (Ma et al, 2005;Azevedo et al, 2011;Makhlof et al, 2011) or added after TPP addition to chitosan (Ma et al, 2002;Erel et al, 2016).…”

Section: Drug Encapsulation Intomentioning

confidence: 99%

How the Lack of Chitosan Characterization Precludes Implementation of the Safe-by-Design Concept

Marques

Som

Schmutz

et al. 2020

Front. Bioeng. Biotechnol.

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Efficacy and safety of nanomedicines based on polymeric (bio)materials will benefit from a rational implementation of a Safe-by-Design (SbD) approach throughout their development. In order to achieve this goal, however, a standardization of preparation and characterization methods and their accurate reporting is needed. Focusing on the example of chitosan, a biopolymer derived from chitin and frequently used in drug and vaccine delivery vector preparation, this review discusses the challenges still to be met and overcome prior to a successful implementation of the SbD approach to the preparation of chitosan-based protein drug delivery systems.

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“…There are many different protocols for insulin encapsulation into Chit NPs (Figure 2). Insulin can be pre-dissolved in diluted hydrogen chloride (HCl) solution (Abbad et al, 2015), the pH of this final solution can be adjusted with sodium hydroxide (NaOH) (Hecq et al, 2015;, or insulin can even be directly solubilized into diluted NaOH, or directly into TPP solution (Zhao et al, 2014). Then, the insulin solution is added to the chitosan solution right before or during TPP addition (Ma et al, 2005;Azevedo et al, 2011;Makhlof et al, 2011) or added after TPP addition to chitosan (Ma et al, 2002;Erel et al, 2016).…”

Section: Drug Encapsulationmentioning

confidence: 99%

Polymeric Nano-Biomaterials for Medical Applications: Advancements in Developing and Implementation Considering Safety-By-Design Concepts

2020

Frontiers Research Topics

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The compilation of articles constituting this eBook is the property of Frontiers.Each article within this eBook, and the eBook itself, are published under the most recent version of the Creative Commons CC-BY licence.The version current at the date of publication of this eBook is CC-BY 4.0. If the CC-BY licence is updated, the licence granted by Frontiers is automatically updated to the new version.When exercising any right under the CC-BY licence, Frontiers must be attributed as the original publisher of the article or eBook, as applicable.Authors have the responsibility of ensuring that any graphics or other materials which are the property of others may be included in the CC-BY licence, but this should be checked before relying on the CC-BY licence to reproduce those materials. Any copyright notices relating to those materials must be complied with.Copyright and source acknowledgement notices may not be removed and must be displayed in any copy, derivative work or partial copy which includes the elements in question.

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Development and Optimization of Insulin-Chitosan Nanoparticles

Cited by 12 publications

References 15 publications

Extraction optimization and characterization of polysaccharide antioxidants from <i>Pinellia ternata</i> (Thunb) Breit rhizome

Extraction optimization and characterization of polysaccharide antioxidants from <i>Pinellia ternata</i> (Thunb) Breit rhizome

How the Lack of Chitosan Characterization Precludes Implementation of the Safe-by-Design Concept

Polymeric Nano-Biomaterials for Medical Applications: Advancements in Developing and Implementation Considering Safety-By-Design Concepts

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