Development and optimization of fluoxetine orally disintegrating tablets using Box-Behnken design

Abstract

concentration (X1), lubricant mixing time (X2), and compression force (X3) and then their effect was monitored on tablet weight (Y1), thickness (Y2), hardness (Y3), % friability (Y4), and disintegration time (Y5). Results: All powder blends showed acceptable flow properties, ranging from good to excellent. The disintegration time (Y5) was affected directly by lubricant concentration (X1). Lubricant mixing time (X2) had a direct effect on tablet thickness (Y2) and hardness (Y3), while compression force (X3) had a direct impact on tablet hardness (Y3), % friability (Y4) and disintegration time (Y5). Accordingly, Box-Behnken design suggested an optimized formula of 0.86 mg (X1), 15.3 min (X2), and 10.6 KN (X3). Finally, the prediction error percentage responses of Y1, Y2, Y3, Y4, and Y5 were 0.31, 0.52, 2.13, 3.92 and 3.75 %, respectively. Formula 4 and 8

Quality by Design (Qbd) as a Tool for the Optimization of Indomethacin Freeze-Dried Sublingual Tablets: In Vitro and in Vivo Evaluation

“…Tablets produced by freeze-drying are of high porosity which allows better exposure of the drug to the dissolution media (saliva in mouth). As a result, an immediate disintegration and dissolution of the tablet occur when placed under the tongue [11][12][13][14][15][16]. The tablet excipients were carefully selected to serve the aim of the research paper in providing a rapid and safe therapeutic action.…”

“…Allows faster distribution of the drug through the bloodstream compared to that of orally administered drugs [6][7][8][9][10]. Freeze-dried sublingual tablets have attracted much attention from researchers as it offers tablets of high porosity which allows better exposure of the drug to the saliva in the mouth resulting in immediate disintegration and dissolution of the tablet when placed under the tongue [11][12][13][14][15][16].…”

Formulation and Evaluation of Olanzepine Microspheres.

“…Where Y is the dependent variable, b0 is the arithmetic mean response of the 9 runs, and bi is the estimated coefficient for the factor Xi. The main effects (X1 and X2) represent the average result of changing one factor at a time and (X1X2) represent interaction factor 10…”

Formulation and Pharmacodynamic Evaluation of Fluoxetine HCl Mucoadhesive Microsphere.

“…Hence the objective of the present work was to formulate the mucoadhesive microsphere of Fluoxetine using Eudragit RS polymer to improve residence time, reduced dosing frequency and increases bioavailability in the treatment of depression. [3][4][5][6]…”