Abstract:The aim of this research was to formulate and evaluate mucoadhesive microspheres of Olanzapine drug to enhance bioavailability and enhance residence time. Olanzepine mucoadhesive microsphere prepared by using sodium alginate polymer and calcium chloride as a crosslinking agent. .Microsphere were prepared by using ionic gelation method. Microsphere with particle size in the range 656.4µm to 659 µm. were prepared by using ionic gelation method. Olanzapine (OLE) having extensive hepatic first pass metabolism and … Show more
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