Development and optimization of chitosan coated nanoemulgel of telmisartan for intranasal delivery: A comparative study

Chin, Ling Yuan; Tan, Joyce Yi Pei; Choudhury, Hira; Pandey, Manisha; Sisinthy, Sreenivas Patro; Gorain, Bapi

doi:10.1016/j.jddst.2021.102341

Cited by 29 publications

(18 citation statements)

References 34 publications

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“…The TC-P was used as permeation enhancer due to its nontoxic and biocompatible nature. Several studies reported its permeation-enhancing effect through a synthetic membrane and on excised skin, reported in previous studies with different drugs [ 31 , 36 , 37 , 38 ]. Figure 8 a shows the cumulative PG permeation from donor to acceptor phase through a synthetic cellulose membrane impregnated with isopropyl myristate.…”

Section: Resultsmentioning

confidence: 99%

Development and Characterization of n-Propyl Gallate Encapsulated Solid Lipid Nanoparticles-Loaded Hydrogel for Intranasal Delivery

et al. 2021

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The objective of the present study was to develop n-propyl gallate-loaded solid lipid nanoparticles (PG-SLNs) in a hydrogel (HG) formulation using Transcutol-P (TC-P) as a permeation enhancer. Modified solvent injection technique was applied to produce optimized PG-SLNs via the Quality by Design approach and central composite design. The in vitro mucoadhesion, scavenging activity, drug release, permeation studies of PG from PG-SLNs-loaded HG were evaluated under simulated nasal conditions. Compared with in vitro release behavior of PG from SLNs, the drug release from the PG-SLNs-loaded HG showed a lower burst effect and sustained release profile. The cumulative permeation of PG from PG-SLNs-loaded HG with TC-P was 600 μg/cm2 within 60 min, which is 3–60-fold higher than PG-SLNs and native PG, respectively. Raman mapping showed that the distribution of PG-SLNs was more concentrated in HG having lower concentrations of hyaluronic acid. The scavenging assay demonstrated increased antioxidant activity at higher concentrations of HG. Due to enhanced stability and mucoadhesive properties, the developed HG-based SLNs can improve nasal absorption by increasing residence time on nasal mucosa. This study provides in vitro proof of the potential of combining the advantages of SLNs and HG for the intranasal delivery of antioxidants.

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Section: Resultsmentioning

confidence: 99%

Development and Characterization of n-Propyl Gallate Encapsulated Solid Lipid Nanoparticles-Loaded Hydrogel for Intranasal Delivery

et al. 2021

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“…Viscosities were measured using a Brookfield viscometer (DV2T, Brookfield Engineering Laboratory, Middleborough, MA, USA) at two different temperatures of 25 °C and 37 °C [ 11 , 14 ], at the speed of 100 rpm using spindle numbers LV 02 and LV 04, respectively.…”

Section: Methodsmentioning

confidence: 99%

Development of In-Situ Spray for Local Delivery of Antibacterial Drug for Hidradenitis Suppurativa: Investigation of Alternative Formulation

et al. 2021

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Hidradenitis suppurativa (HS) has been considered an orphan disease with limited treatments available. The available topical treatment for this condition is clindamycin lotion; however, short retention and frequent application are the main setbacks. Thus, the present study aimed to attain an optimized antibacterial in situ spray formulation for the hidradenitis suppurativa skin condition, which gels once in contact with the skin surface at around 37 °C and possesses bioadhesion as well as sustained-release properties of the incorporated drug. Different concentrations of thermo-reversible gelling polymer, Pluronic F-127, were investigated along with the selected bioadhesive polymers, HPMC and SA. The optimized formulation F3 consisting of 18% Pluronic F-127 with 0.2% HPMC and 0.2% SA was characterized based on various physicochemical properties. The gelation temperature of F3 was found to be 29.0 ± 0.50 °C with a gelation time of 1.35 ± 0.40 min and a pH of 5.8. F3 had the viscosity of 178.50 ± 5.50 cP at 25 °C and 7800 ± 200 cP at 37 °C as the gel set. The optimized formulation was found to be bioadhesive and cytocompatible. Cumulative drug release was 65.05% within the time-frame of 8 h; the release pattern of the drug followed zero-order kinetics with the Higuchi release mechanism. The average zone of inhibition was found to be 43.44 ± 1.34 mm. The properties of F3 formulation reflect to improve residence time at the site of application and can enhance sustained drug release. Therefore, it could be concluded that optimized formulation has better retention and enhanced antimicrobial activity for superior efficacy against HS.

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“…Gupta and colleagues previously developed timolol pH-responsive in situ gel by employing two pH-sensitive polymers, carbomer and chitosan [56]. Chitosan played a role as a viscosity enhancer and lowered the concentration needed for carbomer to form a stiff gel [56,77]. Comparing the optimized in situ gel with liposomes and marketed drops (Glucomol ® ) disclosed that the developed in situ gel formulation could release up to 24 h steadily, obeying Fickian diffusion comparable with liposomes formulation.…”

Section: Recent Researches On the Application Of Ph-responsive In Situ Ocular Gelling Systems Ocular Hypertension (Glaucoma)mentioning

confidence: 99%

“…On the contrary, the innovative in situ ocular gel formulation was retained on the cornea surface for a longer period and did not enter into the systemic circulation. The main reason is that chitosan has both viscous and bioadhesive properties [77,105]. Furthermore, the final viscosity of the innovative formulation was enhanced, and the more rigid gel was formed due to the dual gelling mechanism [96].…”

Section: Ocular Hypertension (Glaucoma)mentioning

confidence: 99%

Potential of Stimuli-Responsive In Situ Gel System for Sustained Ocular Drug Delivery: Recent Progress and Contemporary Research

et al. 2021

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Eyesight is one of the most well-deserved blessings, amid all the five senses in the human body. It captures the raw signals from the outside world to create detailed visual images, granting the ability to witness and gain knowledge about the world. Eyes are exposed directly to the external environment; they are susceptible to the vicissitudes of diseases. The World Health Organization has predicted that the number of individuals affected by eye diseases will rise enormously in the next decades. However, the physical barriers of the eyes and the problems associated with conventional ocular formulations are significant challenges in ophthalmic drug development. This has generated the demand for a sustained ocular drug delivery system, which serves to deliver effective drug concentration at a reduced frequency for consistent therapeutic effect and better patient treatment adherence. Recent advancement in pharmaceutical dosage design has demonstrated that a stimuli-responsive in situ gel system exhibits the favorable characteristics for providing sustained ocular drug delivery and enhanced ocular bioavailability. Stimuli-responsive in situ gels undergo a phase transition (solution–gelation) in response to the ocular environmental temperature, pH, and ions. These stimuli transform the formulation into a gel at the cul de sac to overcome the shortcomings of conventional eye drops, such as rapid nasolacrimal drainage and short contact time with the ocular surface This review highlights the recent successful research outcomes of stimuli-responsive in situ gelling systems in treating in vivo models with glaucoma and various ocular infections. Additionally, it also presents the mechanism, recent development, and safety considerations of stimuli-sensitive in situ gel as the potential sustained ocular delivery system for treating common eye disorders.

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Development and optimization of chitosan coated nanoemulgel of telmisartan for intranasal delivery: A comparative study

Cited by 29 publications

References 34 publications

Development and Characterization of n-Propyl Gallate Encapsulated Solid Lipid Nanoparticles-Loaded Hydrogel for Intranasal Delivery

Development and Characterization of n-Propyl Gallate Encapsulated Solid Lipid Nanoparticles-Loaded Hydrogel for Intranasal Delivery

Development of In-Situ Spray for Local Delivery of Antibacterial Drug for Hidradenitis Suppurativa: Investigation of Alternative Formulation

Potential of Stimuli-Responsive In Situ Gel System for Sustained Ocular Drug Delivery: Recent Progress and Contemporary Research

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