Development and Optimization of an Electrospraying Device for the Continuous Collection of Nano- and Microparticles~!2009-12-01~!2010-01-29~!2010-04-14~!

Abstract

Abstract:The development, fabrication and testing of a compact electrospray device are presented with the dual goal of increasing yields and total particle amounts by orders of magnitude and retaining the monodispersity of the generated polymeric particles. A new and optimized electrospraying device producing 285 mg/24h monodisperse micro-sized particles with a yield of 79.2% was developed and tested. The new design allowed continuous particle production and collection. By optimization of the chamber design, high velocities in combination with reduced turbulences led to increasing yields. In comparison to a simple electrospraying configuration, the new device enabled collection 14.25 times more particles in 24h. Besides this significant increase in particle amounts and numbers, collection effectiveness increased as well. While a basic electrospraying device allowed collection of only 34.7% of the generated particles, the yields determined for the new device were 79.2%. We report a 2.28 times increase in effectiveness combined with the potential to generate continuously particles with enhanced productivity while maintaining monodispersity of the particles. This modified electrospraying device may facilitate the production of micro-and nano-sized particles for biomedical and pharmaceutical applications in relevant amounts and reduced losses inside the device.

Electrohydrodynamic atomization: A two-decade effort to produce and process micro-/nanoparticulate materials

“…The collection efficiency can reach more than 90% in the optimized condition. In a different study, Grafahrend et al (2010) developed a new and optimized electrospraying device consisting of the basic electrospray configuration, a spraying chamber, and a cyclone-type particle collector that can continuously produce 11.875 mg.h −1 monodisperse micro-sized particles with a yield of 79.2% while a basic electrospraying device allowed collection of only 34.7% of the generated particles.…”

Size and morphology controlling of PLGA microparticles produced by electro hydrodynamic atomization

“…This method has many advantages over other methods of atomization such as narrow particle size distribution under controlled behavior because of high charge and good dispersion because of surface charge [18] and the capability of controlling particle size and morphology by varying the processing parameters such as flow rate, [19] collecting distance [20] and needle gauge [21] and solution parameters. [22] The present study explored the application of EHDA technique to obtain microparticles of PLGA as an FDA-approved biocompatible polymer.…”

Pharmaceutical Applications of Electrospraying

“…Compared to the single cone-jet mode, the system produced particles with similar diameter and size distribution. Grafahrend et al 176 also developed a new electrospraying device for continuous production to increase both yield and total particle amounts without loss of monodispersity. Such a device with an optimized chamber design and high velocities in combination with reduced turbulence enabled an increase in collected particles of circa 14 times in 24 h compared to standard electrospraying configuration.…”