Development and in vivo safety assessment of tenofovir-loaded nanoparticles-in-film as a novel vaginal microbicide delivery system

Mucoadhesive Vaginal Discs based on Cyclodextrin and Surfactants for the Controlled Release of Antiretroviral Drugs to Prevent the Sexual Transmission of HIV

“…This is consistent with other studies that evaluate the deformability of freeze-dried systems based on cellulose derivatives, since adding more substances to the systems increases their loss of elasticity [48]. The fracture resistance of solid vaginal formulations, whether tablets or films, is always evaluated to ensure that they are suitable for vaginal administration [49][50][51][52]. An analysis was also conducted on the force required to rupture the discs and the distance they are deformed before breaking; the results are shown in Figure 8.…”

“…The fracture resistance of solid vaginal formulations, whether tablets or films, is always evaluated to ensure that they are suitable for vaginal administration [49][50][51][52]. An analysis was also conducted on the force required to rupture the discs and the distance they are deformed before breaking; the results are shown in Figure 8.…”

Recent advances in the mucus-interacting approach for vaginal drug delivery: from mucoadhesive to mucus-penetrating nanoparticles

“…A recent novel strategy to achieve a prolonged drug permanence into vaginal cavity and an enhanced drug diffusion across the mucus is represented by dual-functioning platforms composed of MPNPs loaded into a bioadhesive formulation, able to release NPs after administration. An example is represented by tenofovir (TFV)-loaded PLGA/stearylamine composite NPs (mean diameter 127 nm) incorporated into a mucoadhesive hydroxypropylmethyl cellulose (HPMC)/PVA-based film [31]. The film was characterized by suitable mechanical properties for vaginal administration and rapidly disintegrated upon contact with simulated vaginal fluid, releasing the loaded NPs.…”

Nanotechnologies for early diagnosis, in situ disease monitoring, and prevention

“…A few studies detailing on NPs in films as potential microbicide products have been described (Table 1.2.2). [128][129][130][131] For example, our group demonstrated the versatility and potential usefulness of NPs-in-film systems for delivering a combination of hydrophobic (efavirenz) and hydrophilic (tenofovir) antiretroviral drugs. 131 Efavirenz-loaded PLGA NPs and tenofovir were incorporated into the polymer matrix during manufacturing by solvent casting.…”