Development and In vitro Evaluation of Self-Adhesive Matrix-Type Transdermal Delivery System of Ondansetron Hydrochloride

David, Sheba R; Rajabalaya, Rajan; Zhia, ES

doi:10.4314/tjpr.v14i2.4

Cited by 18 publications

(7 citation statements)

References 13 publications

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“…Likewise, similar observations were made with other Eudragit polymer grades (RSPO/RLPO) of D and E series patches. A tensile strength of 4 MPa and above is desirable for transdermal patches according to the American Society for Testing and Materials (ASTM) guidelines (23). The data revea led that the average tensile strength of all the patches was in the range of 4.09 to 9.98 MPa, indicating good tensile strength.…”

Section: Thickness and Tensile Strengthmentioning

confidence: 77%

Transdermal delivery of tolterodine tartrate for overactive bladder treatment: In vitro and in vivo evaluation

et al. 2017

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Transdermal delivery of tolterodine tartrate for overactive bladder treatment: In vitro and in vivo evaluationThe purpose of the study was to develop a transdermal tolterodine tartrate (TT) patch and to analyse its effi cacy for overactive bladder (OAB) treatment. Patches were prepared using various polymers and plasticizers via the solvent casting method. The patches were characterized for tensile strength, thickness, moisture content, modulus of elasticity and water absorption capacity. Diff erential scanning calorimetry and Fourier transform infrared analyses were also performed. To determine patch eff ectiveness, in vitro release, permeation and animal studies were performed. The patches showed satisfactory percentage of release, up to 89.9 %, and their mechanical properties included thickness (0.10-0.15 mm), tensile strength (4.62-9.98 MPa) and modulus of elasticity (20-29 MPa). There were no signifi cant interactions between TT and other excipients. Animal studies indicated that the TT patch reduced the incidence of side eff ects; however, studies of longer duration are required to determine the eff ectiveness in treating OAB.

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Section: Thickness and Tensile Strengthmentioning

confidence: 77%

Transdermal delivery of tolterodine tartrate for overactive bladder treatment: In vitro and in vivo evaluation

et al. 2017

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“…The capability of a polymeric nanocomposite film to uptake moisture content from the environment is considered to affect the release rate of the drug from the system. 28 The formulations were subjected to moisture uptake test by weighing each film initially and keeping it in a desiccator containing a saturated solution of sodium chloride. The weight of each film was measured after every 24 hours until a constant weight was achieved.…”

Section: Methodsmentioning

confidence: 99%

Nanoclay-Based Composite Films for Transdermal Drug Delivery: Development, Characterization, and in silico Modeling and Simulation

Sikandar¹,

Shoaib²,

Yousuf³

et al. 2022

IJN

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Purpose Halloysite nanotubes (HNTs) are a versatile and highly investigated clay mineral due to their natural availability, low cost, strong mechanical strength, biocompatibility, and binding properties. The present work explores its role for retarding and controlling the drug release from the composite polymer matrix material. Methods For this purpose, nanocomposite films comprising propranolol HCl and different concentrations of HNTs were formulated using the “solution casting method”. The menthol in a concentration of 1% w/v was used as a permeation enhancer, and its effect on release and permeation was also determined. Quality characteristics of the nanocomposite were determined, and in vitro release and permeation studies were performed using the Franz diffusion system. The data was analyzed using various mathematical models and permeation parameters. Optimized formulation was also subjected to skin irritation test, FTIR, DSC, and SEM study. Systemic absorption and disposition of propranolol HCl from the nanocomposites were predicted using the GastroPlus TCAT® model. Results The control in drug release rate was associated with the higher concentration of HNTs. F8 released 50% of propranolol within 8 hours (drug, HNTs ratio, 1:2). The optimized formulation (F6) with drug: HNTs (2:1), exhibited drug release 80% in 4 hours, with maximum flux of 145.812 µg/cm 2 hr. The optimized formulation was found to be a non-irritant for skin with a shelf life of 35.46 months (28–30 ℃). The in silico model predicted C max , T max , AUC t , and AUC inf as 32.113 ng/mL, 16.58 h, 942.34 ng/mL×h, and 1102.9 ng/mL×h, respectively. Conclusion The study demonstrated that HNTs could be effectively used as rate controlling agent in matrix type transdermal formulations.

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“…The polymeric matrix patches were prepared by solvent casting methods by dissolving 400 mg of Eudragit RS 100 and 300 mg of EC in 5 mL of chloroform with the help of slow magnetic stirrer in a beaker. 11 – 13 Also, 100 mg of copolymer (PVP) and 3 mL of silicone adhesive were added with uniform stirring. Then, to the above solution, DBS plasticizer at 20% of the total polymer weight and 20–40 mg of MP were added and stirred for 30 min.…”

Section: Methodsmentioning

confidence: 99%

Development of controlled release silicone adhesive–based mupirocin patch demonstrates antibacterial activity on live rat skin against <em>Staphylococcus aureus</em>

David¹,

Malek²,

Mahadi³

et al. 2018

DDDT

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BackgroundPeritonitis is the most serious complication of peritoneal dialysis. Staphylococcus aureus infections could lead to peritonitis which causes reversal of peritoneal dialysis treatment back to hemodialysis. The aim of this study was to develop a controlled release silicone adhesive-based mupirocin patch for prophylactic effect and analyze its antibacterial effectiveness against S. aureus.MethodsThe matrix patches were prepared by using different polymers, with and without silicone adhesive, dibutyl sebacate and mupirocin. The patches were characterized for mechanical properties, drug content, moisture content, water absorption capacity and Fourier transform infrared spectrum. In vitro release studies were performed by using Franz diffusion cell. In vitro disk diffusion assay was performed on the Mueller–Hinton Agar plate to measure the zone of inhibition of the patches. The in vivo study was performed on four groups of rats with bacterial counts at three different time intervals, along with skin irritancy and histopathologic studies.ResultsThe patches showed appropriate average thickness (0.63–1.12 mm), tensile strength (5.08–10.08 MPa) and modulus of elasticity (21.53–42.19 MPa). The drug content ranged from 94.5% to 97.4%, while the moisture content and water absorption capacities at two relative humidities (75% and 93%) were in the range of 1.082–3.139 and 1.287–4.148 wt%, respectively. Fourier transform infrared spectra showed that there were no significant interactions between the polymer and the drug. The highest percentage of drug release at 8 hours was 47.94%. The highest zone of inhibition obtained was 28.3 mm against S. aureus. The in vivo studies showed that the bacterial colonies were fewer at 1 cm (7×101 CFU/mL) than at 2 cm (1.3×102 CFU/mL) over a 24-hour period. The patches were nonirritant to the skin, and histopathologic results also showed no toxic or damaging effects to the skin.ConclusionThe in vitro and in vivo studies indicated that controlled release patches reduced the migration of S. aureus on the live rat skin effectively, however, a longer duration of study is required to determine the effectiveness of the patch on a suitable peritonitis-induced animal model.

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Development and In vitro Evaluation of Self-Adhesive Matrix-Type Transdermal Delivery System of Ondansetron Hydrochloride

Cited by 18 publications

References 13 publications

Transdermal delivery of tolterodine tartrate for overactive bladder treatment: In vitro and in vivo evaluation

Transdermal delivery of tolterodine tartrate for overactive bladder treatment: In vitro and in vivo evaluation

Nanoclay-Based Composite Films for Transdermal Drug Delivery: Development, Characterization, and in silico Modeling and Simulation

Development of controlled release silicone adhesive–based mupirocin patch demonstrates antibacterial activity on live rat skin against <em>Staphylococcus aureus</em>

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Development and In vitro Evaluation of Self-Adhesive Matrix-Type Transdermal Delivery System of Ondansetron Hydrochloride

Cited by 18 publications

References 13 publications

Transdermal delivery of tolterodine tartrate for overactive bladder treatment: In vitro and in vivo evaluation

Transdermal delivery of tolterodine tartrate for overactive bladder treatment: In vitro and in vivo evaluation

Nanoclay-Based Composite Films for Transdermal Drug Delivery: Development, Characterization, and in silico Modeling and Simulation

Development of controlled release silicone adhesive&ndash;based mupirocin patch demonstrates antibacterial activity on live rat skin against <em>Staphylococcus aureus</em>

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Product

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About

Development of controlled release silicone adhesive–based mupirocin patch demonstrates antibacterial activity on live rat skin against <em>Staphylococcus aureus</em>