Development and <i>in vivo</i> evaluation of baicalin-loaded W/O nanoemulsion for lymphatic absorption

Xu, Qian; Zhou, An; Wu, Hongfei; Bi, Yujie

doi:10.1080/10837450.2019.1646757

Cited by 30 publications

(10 citation statements)

References 33 publications

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“…QT–NSSPE, QT–NC, and QT coarse powder suspension (QT–CPS) containing 16.2 mg QT were placed in dialysis bags (sigma) with a molecular weight cutoff of 8–14 kDa, respectively. Then, the dialysis bag was tied and immersed into 900 mL of phosphate buffer saline (PBS, pH = 7.4) containing SDS (1%, w / v ) [ 40 ] at 37 °C with a paddle speed of 100 rpm. Samples (1 mL) was withdrawn at 0.5, 1, 2, 4, 6, 8, 12, and 24 h, and immediately replenished with equal volume of the release medium.…”

Section: Methodsmentioning

confidence: 99%

Fabrication and In Vitro/Vivo Evaluation of Drug Nanocrystals Self-Stabilized Pickering Emulsion for Oral Delivery of Quercetin

et al. 2022

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The aim of this study was to develop a new drug nanocrystals self-stabilized Pickering emulsion (NSSPE) for improving oral bioavailability of quercetin (QT). Quercetin nanocrystal (QT–NC) was fabricated by high pressure homogenization method, and QT–NSSPE was then prepared by ultrasound method with QT–NC as solid particle stabilizer and optimized by Box-Behnken design. The optimized QT–NSSPE was characterized by fluorescence microscope (FM), scanning electron micrograph (SEM), X-ray diffraction (XRD), and differential scanning calorimetry (DSC). The stability, in vitro release, and in vivo oral bioavailability of QT–NSSPE were also investigated. Results showed that the droplets of QT–NSSPE with the size of 10.29 ± 0.44 μm exhibited a core-shell structure consisting of a core of oil and a shell of QT–NC. QT–NSSPE has shown a great stability in droplets shape, size, creaming index, zeta potential, and QT content during 30 days storage at 4, 25, and 40 °C. In vitro release studies showed that QT–NSSPE performed a better dissolution behavior (65.88% within 24 h) as compared to QT–NC (50.71%) and QT coarse powder (20.15%). After oral administration, the AUC0–t of QT–NSSPE was increased by 2.76-times and 1.38 times compared with QT coarse powder and QT–NC. It could be concluded that NSSPE is a promising oral delivery system for improving the oral bioavailability of QT.

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Section: Methodsmentioning

confidence: 99%

Fabrication and In Vitro/Vivo Evaluation of Drug Nanocrystals Self-Stabilized Pickering Emulsion for Oral Delivery of Quercetin

et al. 2022

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“…30,31 A negative zeta value on a surface charge was dependent on the composition of the prepared nanoemulsion constituent. 32 The zeta potential assessment is critical because of its relevance to the stability of the dispersion system. When this value is >20 mV, it means the attraction between the droplets is smaller than the repulsion, which can lead to the deflocculation of the vesicles and good physical stability.…”

Section: Evaluation Of the Selected Nanoemulsion Formulationmentioning

confidence: 99%

Face Mask Embedded with Nanoemulsion for Reducing Facial Skin Adverse Effects Caused by Prolonged Wearing the Mask during COVID-19 Management

Alsantali¹,

El-Enin²

2022

Ind. J. Pharm. Edu. Res

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Background: Wearing a facemask is one of the precautionary measures for preventing coronavirus disease spread, which causes many facial skin adverse effects. Vitamin-E (TPGS) and olive oil have an efficient effect on skin moistening. Therefore, in this study, face-masks embedded with NE; prepared using olive oil and TPGS, were developed to reduce the long-wearing face mask adverse effect. Methods: Box-Behnken design was used to develop NE formulations which were physically evaluated to select the most stable formulation. Fibroblast cell lines (3T3) were used to examine NE efficacy on dermal cell proliferation and in vitro cytotoxicity possibilities. Face-masks were also examined for 6 hr wearing dermal compatibility on healthy participants. Results: The formulated NE didn't significantly affect cell proliferation nor had a toxic effect on dermal cells (p<0.05). More than 60% of the respondents were satisfied with masks containing NE. Conclusion:In particular, a face mask embedded with the preparaed selected NE formula could produce emollient feelings during application without retarding the breathing or causing any irritant sensation.

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“…In addition, baicalin nanoemulsions were reported to increase the saturation solubility of baicalin and strengthened their interaction with the mucin layer in epithelial tissues leading to an increased uptake in the intestine. The AUC (0-t) and C max of baicalin from a lipid-based nanoemulsion was reported to be significantly higher (11.5-fold) than baicalin powder for lymphatic system absorption (Xu et al 2019). The in vivo disposition of baicalin is affected by combinations of other herbs, and baicalin can interact with other co-administered drugs due to competition between metabolic enzymes and protein binding (Huang et al 2019).…”

Section: Bioavailabilitymentioning

confidence: 99%

Antiviral Properties of Baicalin: a Concise Review

Liang

Cheng

et al. 2021

Rev. Bras. Farmacogn.

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Baicalin is one of the bioactive flavonoid glycosides isolated from the dried root of Scutellaria baicalensis Georgi, Lamiaceae, with antiviral properties. In recent years, the antiviral activity of baicalin has been widely investigated to explore its molecular mechanism of action. In this mini-review, the molecular mechanisms of action of baicalin as an antiviral agent are evaluated, which included three categories: the inhibition or stimulation of JAK/STAT, TLRs, and NF-κB pathways; up or down modulation of the expression levels of IFN, IL, SOCS1/3, PKR protein, Mx1 protein, and AP-1 protein; and inhibition of cell apoptosis caused by virus infection. In addition, clinical studies of baicalin are also discussed. This literature search suggested that baicalin can serve as a potential candidate for the development of a novel broad-spectrum antiviral drug.

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Development and in vivo evaluation of baicalin-loaded W/O nanoemulsion for lymphatic absorption

Cited by 30 publications

References 33 publications

Fabrication and In Vitro/Vivo Evaluation of Drug Nanocrystals Self-Stabilized Pickering Emulsion for Oral Delivery of Quercetin

Fabrication and In Vitro/Vivo Evaluation of Drug Nanocrystals Self-Stabilized Pickering Emulsion for Oral Delivery of Quercetin

Face Mask Embedded with Nanoemulsion for Reducing Facial Skin Adverse Effects Caused by Prolonged Wearing the Mask during COVID-19 Management

Antiviral Properties of Baicalin: a Concise Review

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