Considering that the identification of equivalent entities is the basis for any comparative analysis, we compare the histology, histochemistry, shape and dimensions of epiphyses, carpal and sesamoids in two anuran frogs. Our goal was to explore the morphological correspondence among these three skeletal elements in order to clarify the sesamoid identity. We studied the skeletogenesis, contour geometric morphometry and dimensions of forelimb elements of juveniles of two anurans species Leptodactylus bufonius and Rhinella arenarum. Skeletogenesis in anurans present a common trait between carpals and sesamoids: both elements exhibit endochondral ossification. A difference between these elements is the presence of fibrocartilage in the development of sesamoids. The geometric morphometry does not allow us to establish a shape pattern that can be compared either between sesamoids and epiphyses or carpals. With regard to dimensions, our data indicate that bones categorization based on these aspects is ambiguous and therefore is useless to classify of skeletal bones. The data about tissue differentiation of sesamoids provide evidence that support the idea that these elements should be considered part of the typical endowment of the vertebrate skeleton. Anat Rec, 298:1376Rec, 298: -1394Rec, 298: , 2015. V C 2015 Wiley Periodicals, Inc.