Development and evaluation of prolonged release pellets obtained by the melt pelletization process

Prilling of fatty acids as a continuous process for the development of controlled release multiparticulate dosage forms

“…Stability issues when using lipid excipients have been reported by different authors [7,10,18]. Influences of storage parameters on drug release were observed by Hamdani et al (2002).…”

“…Influences of storage parameters on drug release were observed by Hamdani et al (2002). The prolonged release of phenylephrine hydrochloride from fatty binder mixtures (Precirol ® and Compritol ® ) was significantly affected by storage after 6 weeks at 40 °C and 75 % relative humidity (RH) [7].…”

“…Influences of storage parameters on drug release were observed by Hamdani et al (2002). The prolonged release of phenylephrine hydrochloride from fatty binder mixtures (Precirol ® and Compritol ® ) was significantly affected by storage after 6 weeks at 40 °C and 75 % relative humidity (RH) [7]. In a study performed by San Vicente et al (2000), salbutamol hydrochloride release was altered after storage for 1 year at room temperature, depending on the type of Gelucire used [18].…”

Drug–excipient interactions in ketoprofen: A vibrational spectroscopy study

“…7,8 The successful formulation of a stable and effective solid dosage form depends on the careful choice of the excipient. Lately, the use of hydrophilic polymers [e.g., cellulose derivatives, polyvinylpyrrolidone (PVP), either isolated or in blends] has attracted considerable attention, 10 due to their ability to form gels in an aqueous medium. Because the in vivo drug release profile, and consequently the bioavailability of the therapeutic agent, may be affected by the occurrence of close contacts with these polymeric compounds, the evaluation of possible drug-excipient interactions is of the utmost importance for the preparation of effective controlledrelease formulations.…”

Formulation of Extended-Release Metformin Hydrochloride Matrix Tablets

“…Also, the decrease in drug release rate when the stearic acid content of the matrix was increased may be due to slower penetration of the dissolution medium in matrices as a result of increased lipophilicity [28] while the initial burst release from the matrix can probably be attributed to the dissolution of drug from the tablet surface. Further, penetration of dissolution fluid was hindered by the hydrophobic coating of stearic acid around the drug particles, leading to diminished drug release over an extended period [29].…”