Development and evaluation of penciclovir-loaded solid lipid nanoparticles for topical delivery

Lv, Qingzhi; Yu, Aibing; Xi, Yang; Li, Houli; Song, Zhen; Cui, Jing; Cao, Fuyang; Zhai, Guangxi

doi:10.1016/j.ijpharm.2009.01.014

Cited by 175 publications

(89 citation statements)

References 48 publications

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“…Mehnert and Mäder (2001) classified these methods into four categories; namely high shear homogenization and ultrasound (Hou et al, 2003), high pressure (hot and cold homogenization) (zur Mühlen et al, 1998;Mehnert & Mäder, 2001;Olbrich et al, 2001;Radomska-Soukharev, 2007;Helgason et al, 2009), solvent emulsification/evaporation, and microemulsion-based SLNs preparation (Mehnert & Mäder, 2001;Heydenreich et al, 2003;Vighi et al, 2007;Kuo & Chen, 2009). In addition to the previous methods, SLNs composed of glyceryl monostearate (GMS) can be successfully prepared by a solvent emulsification-diffusion technique (Trotta et al, 2003) or by a double emulsion technique (Lv et al, 2009). More recently, Hu et al (2002) used a novel solvent diffusion method in aqueous system to prepare SLNs with clobetasol propionate as the loading drug (Hu et al, 2002).…”

Section: Fabrication Of Slnsmentioning

confidence: 99%

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Solid lipid nanoparticles for ocular drug delivery

2010

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Section: Fabrication Of Slnsmentioning

confidence: 99%

“…Double w/o/w emulsion is a relatively new method which has been utilized in recent years to prepare nanoemulsions and SLNs (Lv et al, 2009). Heating is not involved during the process, which makes it suitable for thermo-labile substances.…”

Section: W/o/w Double Emulsionmentioning

confidence: 99%

Solid lipid nanoparticles for ocular drug delivery

2010

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“…Under the optimum preparation conditions, small lipid nanoparticles with a relatively uniform size distribution were obtained. Figure 4 The mean dynamic light scattering particle diameters fell between 111.9 nm and 255 nm with PDI values below 0.3 indicating fair size distributions [25,26]. Encapsulation of water soluble or hydrophilic drug into a solid lipid matrix is one of the challenges associated with this type of formulation and requires appropriate approach to address it [27] So far, the optimized formulation has shown up to 81.75% encapsulation efficiency.…”

Section: Evaluation and Characterization Of Topotecan Slnsmentioning

confidence: 99%

Design, Development and Optimization of Topotecan Hydrochloride Solid Lipid Nanoparticles for Oral Chemotherapy

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et al. 2016

JNMR

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The objective of this research work was to formulate and evaluate solid lipid nanoparticles of anticancer drug topotecan hydrochloride in order to sustain its release and therefore improve its therapeutic outcomes. SLNs were prepared by hot micro emulsion method using glyceryl monostearate as lipid carrier and Tween 80 as surfactant in specific proportions. FT-IR and DSC studies revealed that there was no interaction between drug and lipid. The effect of drug: lipid ratio, surfactant concentration, speed and time of homogenizer on drug release, particle size and EE were studied. The results of particle size, encapsulation efficiency and in vitro drug release at 12hr fell between 111.9 nm and 255nm, 65.12% and 77.63%, and 72.31 and 79.79% respectively. Optimized formulation showed release of drug up to 73.47 % at 12 hrs, entrapment efficiency of 81.75% and particle size of 158.0 nm. The analysis of 3-D graphs revealed that parameters such as drug: lipid ratio and time of homogenization have a profound effect on both encapsulation efficiency and cumulative drug release. Scanning electron microscopy studies showed particles with disuniform surface and shape. The drug release from optimized formulation was found to fit best into first order kinetic model. It also showed almost linear regression in Higuchi's plot suggesting that diffusion is one of the mechanisms for drug release and n value of KorsmeyerPeppas plot was found to be 0.716 indicating that the drug release did not follow fickian diffusion controlled mechanism.

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“…DSC was very useful in the investigation of the thermal properties of microspheres, providing both qualitative and quantitative information about the physicochemical state of drug inside the microspheres (Lv et al, 2009, Rahman et al, 2006. There would be no detectable endothermic peak if the drug was present in a molecular dispersion or solid solution state in the polymeric microspheres (Mu et al, 2001).…”

Section: Dsc Analysismentioning

confidence: 99%