Development and Evaluation of Paclitaxel-Loaded Liposomal Formulations for Targeted Drug Delivery to Breast Cancer

Kannan, Vinayagam

doi:10.21007/etd.cghs.2010.0158

Cited by 1 publication

(2 citation statements)

References 262 publications

(375 reference statements)

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“…The stability of AMB in dispersion form during storage is a major challenge in the development of IONP formulations. Physical instability leads to leakage of loaded drug and aggregation of particles resulting in increased particle size [50]. The physicochemical stability can be improved by removing water from the formulation by lyophilizing the product.…”

Section: Tg' Determination For the Development Of Lyophilization Cyclementioning

confidence: 99%

“…The sugar has a capability of forming an amorphous matrix around the particles that protect from fusion and prevent the rupture of the particles due to the crystallization of ice [51,52]. Even though trehalose is the most widely used lyoprotectant, reports indicate that sucrose has better control over the nanoparticle size than trehalose [50,53]. Additionally, trehalose can also undergo crystallization during lyophilization.…”

Section: Tg' Determination For the Development Of Lyophilization Cyclementioning

confidence: 99%

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Lyophilized Iron Oxide Nanoparticles Encapsulated in Amphotericin B: A Novel Targeted Nano Drug Delivery System for the Treatment of Systemic Fungal Infections

et al. 2020

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We formulated and tested a targeted nanodrug delivery system to help treat life-threatening invasive fungal infections, such as cryptococcal meningitis. Various designs of iron oxide nanoparticles (IONP) (34–40 nm) coated with bovine serum albumin and coated and targeted with amphotericin B (AMB-IONP), were formulated by applying a layer-by-layer approach. The nanoparticles were monodispersed and spherical in shape, and the lead formulation was found to be in an optimum range for nanomedicine with size (≤36 nm), zeta potential (−20 mV), and poly dispersity index (≤0.2), and the drug loading was 13.6 ± 6.9 µg of AMB/mg of IONP. The drug release profile indicated a burst release of up to 3 h, followed by a sustained drug release of up to 72 h. The lead showed a time-dependent cellular uptake in C. albicans and C. glabrata clinical isolates, and exhibited an improved efficacy (16–25-fold) over a marketed conventional AMB-deoxycholate product in susceptibility testing. Intracellular trafficking of AMB-IONP by TEM and confocal laser scanning microscopy confirmed the successful delivery of the AMB payload at and/or inside the fungal cells leading to potential therapeutic advantages over the AMB-deoxycholate product. A short-term stability study at 5 °C and 25 °C for up to two months showed that the lyophilized form was stable.

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Section: Tg' Determination For the Development Of Lyophilization Cyclementioning

confidence: 99%

Section: Tg' Determination For the Development Of Lyophilization Cyclementioning

confidence: 99%

Lyophilized Iron Oxide Nanoparticles Encapsulated in Amphotericin B: A Novel Targeted Nano Drug Delivery System for the Treatment of Systemic Fungal Infections

et al. 2020

View full text Add to dashboard Cite

show abstract

Development and Evaluation of Paclitaxel-Loaded Liposomal Formulations for Targeted Drug Delivery to Breast Cancer

Cited by 1 publication

References 262 publications

Lyophilized Iron Oxide Nanoparticles Encapsulated in Amphotericin B: A Novel Targeted Nano Drug Delivery System for the Treatment of Systemic Fungal Infections

Lyophilized Iron Oxide Nanoparticles Encapsulated in Amphotericin B: A Novel Targeted Nano Drug Delivery System for the Treatment of Systemic Fungal Infections

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