Development and Evaluation of Nitrendipine Nanoemulsion for Intranasal Delivery

Jain, Ratnesh; Patravale, Vandana

doi:10.1166/jbn.2009.031

Cited by 36 publications

(15 citation statements)

References 13 publications

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“…Soybean lecithin is primarily composed of L-α-phosphatidyl choline. Lecithin is frequently used in the preparation of nanoemulsions for drug delivery to the area of interest 37 while Solutol HS15 has been used as a solubilizer or co-surfactant in the preparation of various nanoemulsions 38. Both surfactants are nonionic and ampiphilic which aids in encapsulating and transporting the hydrophobic HMDSO doped with the fluorophore into the interior of the cell.…”

Section: Discussionmentioning

confidence: 99%

Dual-Modality, Dual-Functional Nanoprobes for Cellular and Molecular Imaging

Menon¹,

Gulaka²,

McKay³

et al. 2012

Theranostics

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An emerging need for evaluation of promising cellular therapies is a non-invasive method to image the movement and health of cells following transplantation. However, the use of a single modality to serve this purpose may not be advantageous as it may convey inaccurate or insufficient information. Multi-modal imaging strategies are becoming more popular for in vivo cellular and molecular imaging because of their improved sensitivity, higher resolution and structural/functional visualization. This study aims at formulating Nile Red doped hexamethyldisiloxane (HMDSO) nanoemulsions as dual modality (Magnetic Resonance Imaging/Fluorescence), dual-functional (oximetry/detection) nanoprobes for cellular and molecular imaging. HMDSO nanoprobes were prepared using a HS15-lecithin combination as surfactant and showed an average radius of 71±39 nm by dynamic light scattering and in vitro particle stability in human plasma over 24 hrs. They were found to readily localize in the cytosol of MCF7-GFP cells within 18 minutes of incubation. As proof of principle, these nanoprobes were successfully used for fluorescence imaging and for measuring pO2 changes in cells by magnetic resonance imaging, in vitro, thus showing potential for in vivo applications.

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Section: Discussionmentioning

confidence: 99%

Dual-Modality, Dual-Functional Nanoprobes for Cellular and Molecular Imaging

Menon¹,

Gulaka²,

McKay³

et al. 2012

Theranostics

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“…Intranasal administration of Nitrendipine (NDP), a potent antihypertensive molecule has higher bioavailability (60.44%) than it"s oral administration (10% -20%) 61 .…”

Section: Intranasal Deliverymentioning

confidence: 99%

Untitled

2015

IJPSR

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Since last decade, the interdisciplinary research of Nanoemulsions (NEs) have gained great attention in research and drug designing owing to their promising range of applications in the field of pharmaceutics, drug delivery through different route, cosmetics, to name a few. In addition to the small droplet size these non-equilibrium liquid systems have interesting properties including optical clarity, preparatory ease, thermodynamic stability, high bioavailability, resistant to creaming, flocculation, coalescence and sedimentation, low viscosity and increased surface area, among others. Due to these peculiar properties, NEs have become an authentic tool in the drug delivery system. This article pertains to the types of NEs, characterization techniques, different methods of preparation of stable NEs with special emphasis on the various routes by which drug formulated NEs can be administered. Recent advancements of the fascinating applications of NEs in the delivery of the usually hydrophobic drugs and other bio actives/biotechnology, pharmaceutical ingredients are highlighted.

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“…A Nitrendipine nanoemulsion, comprising Caproyl 90 ® , Tween 80, Transcutol P ® , Solutol HS-15 ® and water, was constructed for nasal administration [123]. Daily nasal administration of the formulations over four consecutive weeks had no discernible effects on histopathology of nasal mucosa.…”

Section: Enhanced Nasal Absorptionmentioning

confidence: 99%

Absorption, Disposition and Pharmacokinetics of Nanoemulsions

Lü

Qi²,

2012

CDM

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Nanoemulsions are composed of nanoscale droplets of one immiscible liquid dispersed within another, which have been the focus of extensive research worldwide due to their solubilization and transportation capacity of both hydrophobic and hydrophilic active compounds with unique physical properties. In a broad sense, submicron-emulsion, microemulsion, self-microemulsifing drug delivery system, lipid emulsion and cholesterol-rich microemulsion (LDE) all belong to nanoemulsions. The review starts with a brief introduction to the definition, formulation rationale, and types of nanoemulaions, and focused on, by different administration routes such as the oral, intravenous, transdermal, ocular nasal and rectal routes, the absorption, disposition, pharmacokinetics properties of nanoemulsions.

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Development and Evaluation of Nitrendipine Nanoemulsion for Intranasal Delivery

Cited by 36 publications

References 13 publications

Dual-Modality, Dual-Functional Nanoprobes for Cellular and Molecular Imaging

Dual-Modality, Dual-Functional Nanoprobes for Cellular and Molecular Imaging

Untitled

Absorption, Disposition and Pharmacokinetics of Nanoemulsions

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