Development and Evaluation of Micropelleted Sustained-Release Suppositories of Terbutaline Sulfate

Arra, G. S.; Biswanath, S. A.; Krishna, D. R.; Arutla, Srinivas; Bandyopadhyay, Amitabha

doi:10.3109/03639049709146163

Cited by 3 publications

(1 citation statement)

References 4 publications

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“…In the case of drugs that are rapidly eliminated from the systemic circulation, frequent administration would be needed to maintain the therapeutic plasma concentration. To reduce the frequency of dosing, several approaches have been performed to prepare SR suppositories by using various polymer such as chitosan (69), Eudragit (70)(71)(72), cellulose acetate phthalate (73), carboxyvinyl polymer (74), and various hydrogel formulation (75,76), were also investigated. Özgüney et.…”

Section: Suppository Formulationsmentioning

confidence: 99%

Conventional and Novel Pharmaceutical Dosage Forms on Prevention of Gastric Ulcers

Özgüney¹

2011

Peptic Ulcer Disease

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Section: Suppository Formulationsmentioning

confidence: 99%

Conventional and Novel Pharmaceutical Dosage Forms on Prevention of Gastric Ulcers

Özgüney¹

2011

Peptic Ulcer Disease

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Polymers in Rectal Drug Delivery

Surti¹,

Mahajan²,

Misra

2021

Applications of Polymers in Drug Delivery

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The Preparation and Evaluation of Sustained Release Suppositories Containing Ketoprofen and Eudragit RL 100 by Using Factorial Design

Özgüney

Özcan

Ertan

et al. 2007

Pharmaceutical Development and Technology

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The preparation of ketoprofen (KP) sustained release (SR) suppositories was designed according to the 3(2) x 2(1) factorial design as three different KP:Eudragit RL 100 ratios (1:0.5, 1:1, 1:2), three particle sizes of prepared granules (250-500, 500-710, and 710-1000 microm) and two different PEG 400:PEG 6000 ratios (40:60, 50:50). The conventional KP suppositories were also prepared by using Witepsol H 15, Massa Estarinum B, Cremao and the mixture of PEG 400:PEG 6000. The dissolution studies of suppositories prepared were carried out according to the USP XXIII basket method in the phosphate buffer (pH = 7.2) at 50 rpm, and it was shown that the dissolution time was sustained up to 8 hours. According to the results of the factorial design, the most important independent variable on t50 and t80 was drug:polymer ratios. The log of partition coefficient of KP was determined as 1.46, showing the high affinity to the oily phase. n exponent and kinetic studies were conducted to explain diffusion mechanism, and it is understood that if the inert KP:Eudragit RL 100 ratio is increased in the particles, the Fickian difusion dominates and the best kinetic turns to Higuchi from the Hixson-Crowell. There is neither crystalline form of KP nor degradation product in the suppositories detected with the differential scanning calorimetry (DSC) studies. In addition to these studies, antiinflammatory activity of SR suppositories also determined that it was significantly extended according to the conventional suppositories.

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Development and Evaluation of Micropelleted Sustained-Release Suppositories of Terbutaline Sulfate

Cited by 3 publications

References 4 publications

Conventional and Novel Pharmaceutical Dosage Forms on Prevention of Gastric Ulcers

Conventional and Novel Pharmaceutical Dosage Forms on Prevention of Gastric Ulcers

Polymers in Rectal Drug Delivery

The Preparation and Evaluation of Sustained Release Suppositories Containing Ketoprofen and Eudragit RL 100 by Using Factorial Design

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