Development and Evaluation of Lornoxicam Loaded Electrospun Nanofibers for Oral Extended Release

Varma, M. Mohan; Harika, A. L.; Sravani, V. Venkata

doi:10.1166/jbns.2013.1141

Cited by 5 publications

(4 citation statements)

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“…The protein expression levels of p-ERK1/2, ERK1/2 and GAPDH in the SH-SY5Y cells that were cultured on PLLA films (control group), aligned PLLA nanofibers (AF group) and aligned PLLA nanofibers with the cell culture medium in addition with 0.5 mg/mL pentapeptide GRGDS (GA group). engineering, [22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38] it will be important to investigate the interaction mechanism between cells and materials fabricated by nanotechnologies. We believe that the results shown above might be helpful to guide the design and application of aligned nanofibers in regeneration medicine fields such as nerve tissue engineering.…”

Section: Effects Of Aligned Plla Nanofibers On Thementioning

confidence: 99%

The Interactions Between Aligned Poly(L-Lactic Acid) Nanofibers and SH-SY5Y Cells In Vitro

Meng

Man

et al. 2016

j nanosci nanotechnol

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Aligned nanofibers have been regarded as promising nanomaterials in facilitating nerve regeneration. Investigating the interactions between aligned nanofibers and neuronal cells will be critically important for the design and application of aligned nanofibers in nerve tissue engineering. In this study, we explored the effects of electrospun Poly(L-Lactic Acid) (PLLA) aligned nanofibers on SH-SY5Y cells (a type of human neuroblastoma cell line) and specifically focused on the role of integrin in the PLLA aligned nanofiber-SH-SY5Y cell interaction. We found that PLLA aligned nanofibers could significantly guide the neurite outgrowth of SH-SY5Y cell, and promote the viability, proliferation, glucose and lactic acid metabolism of SH-SY5Y cell. This promotion effect could be alleviated when the functions of integrins on the SH-SY5Y cell membrane were hampered by pentapeptide GRGDS. Moreover, we found that PLLA aligned nanofibers could enhance the expression of phosphorylated-ERK1/2 (p-ERK1/2) in the SH-SY5Y cells and blocking the integrins would decrease p-ERK1/2 expression. These results suggested that PLLA aligned nanofibers might affect many cellular behaviors of SH-SY5Y cells via integrin mediated ERK pathway. Our findings provided more insights for understanding the interaction between aligned nanofibers and neuronal cells.

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Section: Effects Of Aligned Plla Nanofibers On Thementioning

confidence: 99%

The Interactions Between Aligned Poly(L-Lactic Acid) Nanofibers and SH-SY5Y Cells In Vitro

Meng

Man

et al. 2016

j nanosci nanotechnol

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“…[24][25][26][27][28] The solution was prepared with MLX:PVP:HP--CD in the ratio of 1:5:0.5 (w/w). MLX was dissolved in dimethylformamide to obtain a suspension.…”

Section: Preparation Of MLX Nanofibers Bymentioning

confidence: 99%

Design and Evaluation of Electrospun Nanofibers for the Enhancement of Dissolution Rate of Meloxicam

Varma¹,

Sravani²,

Swamy³

2013

j bionanosci

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Up to 40 percent of new chemical entities discovered by the pharmaceutical industry today are poorly soluble and lipophilic compounds. The poor solubility and wettability of meloxicam leads to poor dissolution and hence the drug shows poor bioavailability. The present study is aimed at increasing the dissolution rate of the drug using the electrospinning technique. The nanofibers were prepared using the different drug:polymer ratios. The optimized formulation was characterized by fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), differential scanning calorimetry (DSC), X-ray diffraction (XRD) and the in-vitro dissolution rate studies. The meloxicam nanofibers prepared by electrospinning technique demonstrated higher drug release rate in comparison to the pure meloxicam. Moreover, in this technique the process parameters: feed rate, voltage, distance, were also optimised to obtain the maximum nanofiber yield and the satisfactory particle size.

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“…As the development of cancer therapy, theranostic treatment has been highlighted. [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] Carbon nanoparticle in CNSI is a promising drug carrier for its huge surface area. 24 25 Combining with the lymph node targeting and mapping properties, CNSI is a potential carrier for theranostic of metastatic cancer.…”

Section: Introductionmentioning

confidence: 99%

Drug-Loaded Carbon Nanoparticle Suspension Injection: Drug Selection, Releasing Behavior, <I>In Vitro</I> Cytotoxicity and <I>In Vivo</I> Lymph Node Targeting

Xie¹,

Tang²,

Li³

et al. 2016

j nanosci nanotechnol

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In this study, drug-loaded carbon nanoparticle suspension as theranostic carrier was prepared for lymph node targeting delivery. Five model anti-cancer drugs were chosen to evaluate the drug selection, drug loading and releasing performance of carbon nanoparticle suspension. The relative recovery, precision, stability and limited detection range were studied in details. We found that the CNSI selectively adsorbed DOX and EPI and hardly adsorbed PTX, CDDP and 5-FU. The isothermal curves of CNSI adsorption to DOX and EPI are all fitted well with the Freundlich model. The adsorption process is not monolayer adsorption. By in vivo topical administration of DOX-loaded CNSI and EPI-loaded CNSI, we found that the drug-loaded CNSI were not only maintained its lymph node staining properties but also targeted delivery the drugs to the lymph node. The results demonstrated that the CNSI is not only used to vital staining of lymph vessels and lymph nodes but also can be used as drug delivery carrier. CNSI is a promising theranostic carrier for DOX or EPI delivery in cancer therapy.

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Development and Evaluation of Lornoxicam Loaded Electrospun Nanofibers for Oral Extended Release

Cited by 5 publications

References 0 publications

The Interactions Between Aligned Poly(L-Lactic Acid) Nanofibers and SH-SY5Y Cells In Vitro

The Interactions Between Aligned Poly(L-Lactic Acid) Nanofibers and SH-SY5Y Cells In Vitro

Design and Evaluation of Electrospun Nanofibers for the Enhancement of Dissolution Rate of Meloxicam

Drug-Loaded Carbon Nanoparticle Suspension Injection: Drug Selection, Releasing Behavior, <I>In Vitro</I> Cytotoxicity and <I>In Vivo</I> Lymph Node Targeting

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