Design and Evaluation of Electrospun Nanofibers for the Enhancement of Dissolution Rate of Meloxicam

Varma, M. Mohan; Sravani, V. Venkata; Swamy, P. V.

doi:10.1166/jbns.2013.1185

Cited by 7 publications

(4 citation statements)

References 10 publications

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“…Electrohydrodynamic atomization technique has been applied for the preparation of drug-loaded nanofibers for many aims, with interest in its utilization for bioavailability enhancement of poorly soluble drugs (Varma and Sravani 2013).…”

Section: Physicochemical Characterization Of the Optimized Composite mentioning

confidence: 99%

Electrohydrodynamic atomization, a promising avenue for fast-dissolving drug delivery system: Lessons from tadalafil-loaded composite nanofibers

2020

J app pharm sci

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The utilization of electrospinning in drug delivery has thrived in recent years, with the ability to incorporate drugs and enhance dissolution; this technique is employed to improve the dissolution of poorly water-soluble selective phosphodiesterase-5 inhibitor, tadalafil. The strategy involved direct electrospinning of tadalafil/polyvinylpyrrolidone and polyethylene oxide (PEO) solution. The optimization process included a 3 2 full factorial design based on the influence of polymers concentration as independent variables on the electrospun yield, loading efficiency, nanofibers diameter, number of beads, and in vitro release. Optimization studies revealed the negative influence of both polymers on the electrospun yield, while the loading efficiency and in vitro dissolution rate were reduced by the PEO concentration solely. The higher polymer concentrations were favorable for the declination of beads number, and a driving factor for fiber diameter reduction. Further physicochemical characterization of the optimized formulation revealed the presence of the drug in an amorphous state or molecular dispersion within the polymer matrix. In vitro dissolution studies revealed about 81.5% ± 8.34% release in less than 2 minutes compared to a negligible dissolution of free drug. From the derived outcomes, the electrohydrodynamic spun tadalafil-loaded nanofibers pave the way for dissolution enhancement for insoluble low bioavailability class II drugs.

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Section: Physicochemical Characterization Of the Optimized Composite mentioning

confidence: 99%

Electrohydrodynamic atomization, a promising avenue for fast-dissolving drug delivery system: Lessons from tadalafil-loaded composite nanofibers

2020

J app pharm sci

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“…The protein expression levels of p-ERK1/2, ERK1/2 and GAPDH in the SH-SY5Y cells that were cultured on PLLA films (control group), aligned PLLA nanofibers (AF group) and aligned PLLA nanofibers with the cell culture medium in addition with 0.5 mg/mL pentapeptide GRGDS (GA group). engineering, [22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38] it will be important to investigate the interaction mechanism between cells and materials fabricated by nanotechnologies. We believe that the results shown above might be helpful to guide the design and application of aligned nanofibers in regeneration medicine fields such as nerve tissue engineering.…”

Section: Effects Of Aligned Plla Nanofibers On Thementioning

confidence: 99%

The Interactions Between Aligned Poly(L-Lactic Acid) Nanofibers and SH-SY5Y Cells In Vitro

Meng

Man

et al. 2016

j nanosci nanotechnol

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Aligned nanofibers have been regarded as promising nanomaterials in facilitating nerve regeneration. Investigating the interactions between aligned nanofibers and neuronal cells will be critically important for the design and application of aligned nanofibers in nerve tissue engineering. In this study, we explored the effects of electrospun Poly(L-Lactic Acid) (PLLA) aligned nanofibers on SH-SY5Y cells (a type of human neuroblastoma cell line) and specifically focused on the role of integrin in the PLLA aligned nanofiber-SH-SY5Y cell interaction. We found that PLLA aligned nanofibers could significantly guide the neurite outgrowth of SH-SY5Y cell, and promote the viability, proliferation, glucose and lactic acid metabolism of SH-SY5Y cell. This promotion effect could be alleviated when the functions of integrins on the SH-SY5Y cell membrane were hampered by pentapeptide GRGDS. Moreover, we found that PLLA aligned nanofibers could enhance the expression of phosphorylated-ERK1/2 (p-ERK1/2) in the SH-SY5Y cells and blocking the integrins would decrease p-ERK1/2 expression. These results suggested that PLLA aligned nanofibers might affect many cellular behaviors of SH-SY5Y cells via integrin mediated ERK pathway. Our findings provided more insights for understanding the interaction between aligned nanofibers and neuronal cells.

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“…As the development of cancer therapy, theranostic treatment has been highlighted. [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] Carbon nanoparticle in CNSI is a promising drug carrier for its huge surface area. 24 25 Combining with the lymph node targeting and mapping properties, CNSI is a potential carrier for theranostic of metastatic cancer.…”

Section: Introductionmentioning

confidence: 99%

Drug-Loaded Carbon Nanoparticle Suspension Injection: Drug Selection, Releasing Behavior, <I>In Vitro</I> Cytotoxicity and <I>In Vivo</I> Lymph Node Targeting

Xie¹,

Tang²,

Li³

et al. 2016

j nanosci nanotechnol

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In this study, drug-loaded carbon nanoparticle suspension as theranostic carrier was prepared for lymph node targeting delivery. Five model anti-cancer drugs were chosen to evaluate the drug selection, drug loading and releasing performance of carbon nanoparticle suspension. The relative recovery, precision, stability and limited detection range were studied in details. We found that the CNSI selectively adsorbed DOX and EPI and hardly adsorbed PTX, CDDP and 5-FU. The isothermal curves of CNSI adsorption to DOX and EPI are all fitted well with the Freundlich model. The adsorption process is not monolayer adsorption. By in vivo topical administration of DOX-loaded CNSI and EPI-loaded CNSI, we found that the drug-loaded CNSI were not only maintained its lymph node staining properties but also targeted delivery the drugs to the lymph node. The results demonstrated that the CNSI is not only used to vital staining of lymph vessels and lymph nodes but also can be used as drug delivery carrier. CNSI is a promising theranostic carrier for DOX or EPI delivery in cancer therapy.

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Design and Evaluation of Electrospun Nanofibers for the Enhancement of Dissolution Rate of Meloxicam

Cited by 7 publications

References 10 publications

Electrohydrodynamic atomization, a promising avenue for fast-dissolving drug delivery system: Lessons from tadalafil-loaded composite nanofibers

Electrohydrodynamic atomization, a promising avenue for fast-dissolving drug delivery system: Lessons from tadalafil-loaded composite nanofibers

The Interactions Between Aligned Poly(L-Lactic Acid) Nanofibers and SH-SY5Y Cells In Vitro

Drug-Loaded Carbon Nanoparticle Suspension Injection: Drug Selection, Releasing Behavior, <I>In Vitro</I> Cytotoxicity and <I>In Vivo</I> Lymph Node Targeting

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