Development and Evaluation of Fast-Dissolving Film of Salbutamol Sulphate

Mashru, Rajashree; Sutariya, Vijay B.; Sankalia, Mayur G.; Parikh, Priti

doi:10.1081/ddc-43947

Cited by 156 publications

(78 citation statements)

References 13 publications

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“…[24] Transparencyof the film Transparency of the film can be determined by using UV Visible spectrophotometer. Selected film is cut as per the size of the sample holder and placed inside the UV Visible spectrophotometer.…”

Section: Morphology Studyof the Filmmentioning

confidence: 99%

Significance of Fast Dissolving Oral Films and Its Novel Approach Towards Drug Delivery–a Review

Haque¹

2017

WJPR

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Novel drug delivery system is one of the frontier areas of research towards achieving an innovative technique for drug administration which can improve drug safety, therapeutic efficacy, stability and selflife of an active drug. Over the past few decades, it is chosen as an important area of research to develop innovative methods for the health sector and pharmaceutical industries. Fast dissolving oral films (FDOFs) in the year of 1970 initiated as an alternative to the existing drug delivery system such as tablet, capsule, parenteral, syrup, emulsion, cream and ointment. FDOFs are one of the most popular drug delivery system due to its flexibility and comfort of use. These films have a potential to absorb the drug through oral buccal mucosa and directly enter to the systemic circulation by fast-pass metabolism.These films have a potential to provide better drug utilization by delivering systemically through intra-gastric and sublingual. These films are gaining popularity due to rapid drug absorption and immediate onset of action within a few minutes of administration in buccal cavity. FDOFs are very convenient to pediatric, geriatric and bedridden patient who faces difficulty in swallow. FDOFs can be used for the treatment of common cold, mouth ulcer, cardiac problem, sore throat and allergic conditions etc. These films can be formulated by simple methods using several ingredients such as polymers, active medicaments, stabilizing agent, surfactants, sweetening agent, flavoring agent coloring agent and saliva stimulating agent. Evaluation of FDOFs can be done by checking several parameters such as thickness, folding endurance, tensile strength, percentage of elongation anddisintegration test.Additionally, drug content and dissolution test are carried out to determine amount of active

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Section: Morphology Studyof the Filmmentioning

confidence: 99%

Significance of Fast Dissolving Oral Films and Its Novel Approach Towards Drug Delivery–a Review

Haque¹

2017

WJPR

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“…Scanning electron microscopy (SEM) at a definite magnification is used to study the morphology of study (Mashru et al, 2005).…”

Section: Morphology Studymentioning

confidence: 99%

“…Special controlled human taste panels are used for product evaluation. For this purpose, invitro methods of utilizing taste sensors, specially designed apparatus and drug release by modified pharmacopoeial methods are used (Mashru et al, 2005). To differentiate between sweetness level in taste making formulation, experiments by using electronic tongue measurements were performed (Anand et al, 2007).…”

Section: Organoleptic Evaluationmentioning

confidence: 99%

Oral Films: A Comprehensive Review

et al. 2016

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In the late 1970s, rapid disintegrating drug delivery system was developed as an alternative to capsules, tablets and syrups for geriatric and pediatric patients having problems in swallowing. To overcome the need, number of orally disintegrating tablets which disintegrate within one minute in mouth without chewing or drinking water were commercialized. Then later, oral drug delivery technology had been improved from conventional dosage form to modified release dosage form and developed recently rapid disintegrating films rather than oral disintegrating tablets. Oral disintegrating film or strips containing water dissolving polymer retain the dosage form to be quickly hydrated by saliva, adhere to mucosa, and disintegrate within a few seconds, dissolve and releases medication for oro-mucosal absorption when placed in mouth. Oral film technology is the alternative route with first pass metabolism. This review give a comprehensive detail of materials used in ODF, manufacturing process, evaluation tests and marketed products.Mahboob et al., International Current Pharmaceutical Journal, November 2016, 5(12): 111-117http://www.icpjonline.com/documents/Vol5Issue12/03.pdf

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“…In vitro dissolution studies were carried out for the films using U.S.P. dissolution 12 apparatus I (Paddle type) . Disintegration test was carried out 2 by taking six 2 x 2 cm films.…”

Section: Evaluation Of Fast Dissolving Filmsmentioning

confidence: 99%

Formulation and Evaluation of Fast Dissolving Tablets of Ondansetron by Solid Dispersion in Superdisintegrants

Suthar¹,

Chotai²,

Shah³

2013

IJPER

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The present study deals with the formulation of fast dissolving films of nizatidine as a model drug which is used for the treatment of acid-reflux disorders, peptic ulcer disease, and active duodenal ulcer. Rapidly dissolving dosage forms have acquired great importance in pharmaceutical industry because of their unique properties. In the present research work various trails were carried out using maltodextrin and the concentration of excipients were optimized to prepare an ideal film for drug loading. Casting method was used for the preparation of films. The prepared films were evaluated for film thickness, folding endurance, disintegration time, dissolution time and for drug content. The in vitro dissolution studies were carried out in three media, distilled water, simulated gastric fluid ( pH 1.2 ) and simulated salivary fluid ( pH 6.8 ). The prepared films were found to be uniform, flexible, more than 90 % of the drug was found to be released from the film with in 4 min which is a desirable characteristic for fast absorption. FT IR and DSC studies were carried out to study drug excipient interactions. From these studies it is observed that there was no interaction between drug and excipients used and the drug is stable in the formulation. The in vivo disintegration time and taste evaluation studies were carried out in human volunteers after taking approval by the ethical committee, IPT, SPMVV(Sri padmavathi mahila Visva Vidyalayam). These results revealed that there was no bitter taste, no irritation and good mouth fell was observed. The in vivo disintegration time was in agreement with in vitro results. This confirms the successful formulation of nizatidine in the form of fast dissolving films.

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Development and Evaluation of Fast-Dissolving Film of Salbutamol Sulphate

Cited by 156 publications

References 13 publications

Significance of Fast Dissolving Oral Films and Its Novel Approach Towards Drug Delivery–a Review

Significance of Fast Dissolving Oral Films and Its Novel Approach Towards Drug Delivery–a Review

Oral Films: A Comprehensive Review

Formulation and Evaluation of Fast Dissolving Tablets of Ondansetron by Solid Dispersion in Superdisintegrants

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