Significance of Fast Dissolving Oral Films and Its Novel Approach Towards Drug Delivery–a Review

Abstract

Novel drug delivery system is one of the frontier areas of research towards achieving an innovative technique for drug administration which can improve drug safety, therapeutic efficacy, stability and selflife of an active drug. Over the past few decades, it is chosen as an important area of research to develop innovative methods for the health sector and pharmaceutical industries. Fast dissolving oral films (FDOFs) in the year of 1970 initiated as an alternative to the existing drug delivery system such as tablet, capsule, parenteral, syrup, emulsion, cream and ointment. FDOFs are one of the most popular drug delivery system due to its flexibility and comfort of use. These films have a potential to absorb the drug through oral buccal mucosa and directly enter to the systemic circulation by fast-pass metabolism.These films have a potential to provide better drug utilization by delivering systemically through intra-gastric and sublingual. These films are gaining popularity due to rapid drug absorption and immediate onset of action within a few minutes of administration in buccal cavity. FDOFs are very convenient to pediatric, geriatric and bedridden patient who faces difficulty in swallow. FDOFs can be used for the treatment of common cold, mouth ulcer, cardiac problem, sore throat and allergic conditions etc. These films can be formulated by simple methods using several ingredients such as polymers, active medicaments, stabilizing agent, surfactants, sweetening agent, flavoring agent coloring agent and saliva stimulating agent. Evaluation of FDOFs can be done by checking several parameters such as thickness, folding endurance, tensile strength, percentage of elongation anddisintegration test.Additionally, drug content and dissolution test are carried out to determine amount of active

Formulation and Characterization of Sublingual Tablets of Iloperidone Prepared by Microenvironmental pH Regulated Approach

“…The sublingual route of drug delivery bypasses the hepatic firstpass metabolism leading to desired bioavailability. The drug is absorbed through passive diffusion into the lipoidal membrane, and thus, its absorption is 3-10 folds higher than the conventional oral route [11][12][13].…”

“…While binary complexes demonstrated an enhancement in solubility and dissolution of poorly soluble drugs, a supplement of auxiliary agent, i.e., pH modifier forms ternary phase, has proven further enhancement in solubility and dissolution. The system with the microenvironmental pH approach has successfully resolved the issues of pHdependent solubility for some drugs [13,[15][16][17].…”