Development and evaluation of extended release bioadhesive sodium fluoride tablets

Abstract

Localized fluoride delivery to the oral cavity is important in caries prevention. However, no current marketed dosage forms deliver fluoride for an extended period. This work describes the effect of poly (methyl vinyl ether-co-maleic anhydride) mixed calcium/sodium salt (Gantrez MS), sodium carboxymethylcellulose (NaCMC), polyethylene glycol 8000 (PEG8000) and Carbopol 934 (C934) on the in vitro dissolution and ex vivo bioadhesion of sodium fluoride matrix tablets. Dissolution was studied using USP Apparatus 2 and a low volume (3.1 ml), low flow (0.5 ml/min) dissolution apparatus. In both apparatus, the percent drug dissolved at 2, 4 and 8 h was found to be statistically dependent on the fractions of Gantrez MS and NaCMC. The interaction term was significant at 2 and 4 h (probability > (t) of less than 0.05). Ex vivo bioadhesion was studied using excised bovine gingiva and a TA.XT2i Texture Analyzer. Peak bioadhesive force and work of bioadhesion were found to be statistically dependent on the fractions of Gantrez MS and NaCMC with no interaction (probability > (t) of less than 0.01). Results indicate that bioadhesive matrix fluoride tablets of these mixtures can be designed to exhibit both bioadhesive and extended release properties.

Design and Development of Novel Mucoadhesive Gastroretentive Formulation of Glipizide

“…The balance was kept in this position for 3 minutes after which weights were added slowly to the right pan until the film separated from the mucosal surface. The excess weight on the pan (total weight minus 5 g) is the bio adhesive strength required to separate the film from the mucosa [26][27][28] . The force of adhesion was calculated using the formula: Determination of drug content Accurately cited 2 cm × 2 cm diameter of the films was taken and dissolved in methanol and constant volume of solvent.…”

Development and Evaluation of Mucoadhesive Chlorhexidine Tablet Formulations

“…For local drug delivery, the highly keratinized epidermis of the gingival will present a barrier to systemic absorption. Examples of oral cavity diseases for which buccal dosage forms have been designed include aphthous stomatitis, oral candidiasis, and periodontal disease [14].…”

Formulation and evaluation of buccoadhesive quetiapine fumarate tablets

“…Buccal drug delivery provides a number of advantages like robustness of epithelium, usage of the dosage form in accordance with need, good accessibility and comparatively less susceptibility to enzymatic activity (Shanker et al, 2009) and can administer drugs to patient who cannot be dosed orally to prevent accidental swallowing (Vamshi Vishnu et al, 2007). Therefore, adhesive mucosal dosage forms were developed for oral delivery, in the form of adhesive tablets (Schor et al, 1983;Owens, Dansereau, Sakr, 2005;Akbari et al, 2004), adhesive gels (Bremecker, Strempel, Klein, 1984;Ishida, Vambu, Vagai, 1983;Packer et al, 2001) and adhesive patches (Guo, 1994;Anders, Merkle, 1989).…”