Development and evaluation of an emulsion containing lycopene for combating acceleration of skin aging

Cefali, Letícia Caramori; Souza-Moreira, Tatiana M.; Corrêa, Marcos Antônio; Salgado, Hérida Regina Nunes; Isaac, Vera Lúcia Borges

doi:10.1590/s1984-82502015000300010

Cited by 16 publications

(14 citation statements)

References 18 publications

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“…Previous studies have already demonstrated the importance of the rheology of the pharmaceutical product, stating that the determination of the rheological behavior of the formulation aids in the evaluation of the physicochemical nature of the vehicle in such a way that makes it possible to detect early signs of physical instability allowing control quality of constituents, testing formulations and final products (Cefali, 2009).…”

Section: Resultsmentioning

confidence: 99%

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Challenges in research and development of phytomedicines in semisolid pharmaceutical forms

Mendes¹,

Freitas²

2014

Afr. J. Pharm. Pharmacol.

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The research and development of new drugs is a slow process that involves costs, requires physical, material and qualified human resources. The purpose of this study was to examine the research of recent years exposed on the challenges and obstacles to production and design of semisolid pharmaceutical forms from extracts or isolated compounds from medicinal plants. This study is an integrative review. The sample consisted of scientific articles found on the databases (Lilacs, Scielo, Science Direct and PubMed) from January 2002 to September 2012. The following descriptors were used: phytomedicines, stability of medicines and pharmaceutical preparations. The design of semisolid pharmaceutical forms, especially those in phytocosmetics, is relevant in Brazil, a major producer country by the pharmaceutical industry. However, due to the peculiarity of each drug and medicine, the study design may become one of the great difficulties of its accomplishment, as well as being a challenge to professionals in developing new pharmaceuticals. Thus, it can be suggested that despite the vast Brazilian biodiversity, there is no investment and cooperation in research and development of new medicines.

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Section: Resultsmentioning

confidence: 99%

“…Emulsion is a system consisting of two immiscible liquids, containing one aqueous or hydrophilic part and another oily or lipophilic, where one of the parts is dispersed in another as droplets, becoming homogeneous by the addition of surface-active substances which emulsify the system (Cefali, 2009).…”

Section: Development Of Phytocosmetics In Brazilmentioning

confidence: 99%

Challenges in research and development of phytomedicines in semisolid pharmaceutical forms

Mendes¹,

Freitas²

2014

Afr. J. Pharm. Pharmacol.

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“…This change may have occurred due to the evaporation of water when the phytocosmetic and the control were in the heater. 16,10 For the parameter pH stability was observed from the 10th day of analysis, as shown on Figure 1. The control behaved similarly to the phytocosmetic, which demonstrates that adding glycinin did not alter the properties of the components of the emulsion.…”

Section: Accelerated Stability Testmentioning

confidence: 96%

“…The parameters were analyzed involved possible alterations in aspect, color, smell, pH value and separation of phases. 16 Regarding the parameter aspect, the product must remain intact during all the days of analysis, maintaining the initial appearance, except in high temperatures, freezer or freezing and thawing cycles, when small alterations are acceptable. Regarding the parameters color and smell, they must be stable during the 15 days of testing and small alterations are acceptable only in high temperatures.…”

Section: Accelerated Stability Testing (Ast)mentioning

confidence: 99%

Antimicrobial, antioxidant and anti-inflammatory assessment of a phytocosmetic produced with glycinin peptides

Vasconcellos¹,

Woiciechowski²,

Soccol³

2016

Int J Phytocosmetics Natu Ingredients

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Phytocosmetics are increasingly gaining attention from consumers who search for alternatives for the maintenance and protection of the skin. This article reports formulation of a phytocosmetic derived from defatted soybean flour, an emulsion base that is hydrolyzed from the glycinin protein (1000 µg/g). Test for stability, microbiological control and biological activities antimicrobial (agar diffusion method), antioxidant (method of ABTS/TEAC radicals) and anti-inflammatory (method of hyaluronidase enzyme) properties were conducted. The results indicated that the phytocosmetic was stable and had low indices of microorganisms, according to Resolution 481/99. The bioactivity of the glycinin peptides was not altered or harmed by the other components of the emulsion. For the antimicrobial activity, the bacteria E. coli, S. aureus and P. acnes had values of 30.5 mm, 28 mm and 25 mm halos, respectively. For the antioxidant activity, the result was of 25.1 TEAC and the anti-inflammatory activity was measured at 83.4% inhibition of hyaluronidase enzyme. This study showed that the formulated phytocosmetic has great potential for topical use; it is comparable to other anti-aging cosmetics for daily skin care with antioxidant, anti-inflammatory and antimicrobial properties.

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“…In the formulation containing GB extract, the soft extract was solubilised in 10% of the water (discounted from the total water content of the formulation). Right after preparation and cooling, the extract solution was mixed with vigorous agitation (Cefali et al, 2015).…”

Section: Design Of the Cosmetic Formulationmentioning

confidence: 99%

Assessment of an anti-ageing structured cosmetic formulation containing goji berry

Leite

Oshiro

Chiari-Andréo

2019

Braz. J. Pharm. Sci.

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Based on previous studies, it has been found that goji berry (GB), popularly known as a 'miracle fruit', has excellent antioxidant potential and can be used in the treatment of skin disorders associated with ageing. This study aimed to incorporate GB into a structured cosmetic in order to optimise its penetration. Stability studies of the formulation, determination of the antioxidant activity of the extract and of the formulation, rheological measurements, SAXS, polarised light microscopy and bioadhesion analyses were performed. The results indicated the antioxidant activity of the extract, which can be incorporated into an emulsified cosmetic formulation. The emulsified formulation containing the extract remained stable, even after being submitted to thermal and luminous stresses for 30 days. In addition, rheological tests revealed that the addition of the GB soft extract reduced the viscosity of the formulation, increasing thixotropy and deformation. These systems were characterised by SAXS as a lamellar phase, which was confirmed by polarised light microscopy. These highly organised structures indicate their excellent stability. In vitro bioadhesion experiments revealed that these formulations exhibited skin adhesion strength statistically similar to commercial anti-ageing formulation. These results suggest that this formulation has excellent potential to be used as a topical treatment for ageing.

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Development and evaluation of an emulsion containing lycopene for combating acceleration of skin aging

Cited by 16 publications

References 18 publications

Challenges in research and development of phytomedicines in semisolid pharmaceutical forms

Challenges in research and development of phytomedicines in semisolid pharmaceutical forms

Antimicrobial, antioxidant and anti-inflammatory assessment of a phytocosmetic produced with glycinin peptides

Assessment of an anti-ageing structured cosmetic formulation containing goji berry

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